THE EFFECT OF HUMANIZED ANTIBODIES TO ANGPTL4 ON TRIGLYERIDES & VLDL-LEVELS
THE EFFECT OF HUMANIZED ANTIBODIES TO ANGPTL4 ON TRIGLYERIDES & VLDL-LEVELS
批准号:
8357857
负责人:
KEVIN L GROVE
金额:
$5.82万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-05-01 至 2012-04-30
关键词:
AnimalsAntibodiesCoronary heart diseaseDevelopmentDiabetes MellitusDyslipidemiasEnzymesFundingFutureGrantHypertriglyceridemiaInvestigationLeadNational Center for Research ResourcesObesityPaperPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesRisk FactorsSourceTestingUnited States National Institutes of HealthVery low density lipoproteinblood glucose regulationcosthumanized antibodyimmune functionimprovedlipoprotein lipasenonhuman primatevery low density lipoprotein triglyceride
中文摘要
该子项目是利用资源的许多研究子项目之一
由NIH/NCRR资助的中心赠款提供。次级项目的主要支助
子项目的主要研究者可能是由其他来源提供的,
包括其他NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
高水平的甘油三酯和极低密度脂蛋白(也称为血脂异常)被广泛认为是冠心病和糖尿病发展的主要危险因素。该研究测试了人源化ANGPTL 4抗体通过激活脂蛋白脂肪酶来增加甘油三酯清除率的能力。 在这项原理研究的证明中,我们确定了这些抗体是否可以有效地降低甘油三酯和VLDL并改善肥胖非人灵长类动物的葡萄糖稳态。 这些研究将在未来扩展,以研究长期治疗和其他终点的研究(即,免疫功能的改善),这将导致一个可降解的文件。这些研究使用来自肥胖NHP资源的动物。 进展:这些研究已经完成。
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
High levels of triglycerides and VLDL (also known as dyslipidemia) are widely accepted to be a major risk factor in the development of coronary heart disease and diabetes. This study tested the ability humanized ANGPTL4 antibodies to increase triglyceride clearance through activation of the lipoprotein lipase enzyme. In this proof of principle study we determined whether these antibodies can effectively reduce triglycerides and VLDL and improve glucose homeostasis in obese nonhuman primates. These studies will be expanded in the future to investigate prolonged treatment and investigation of other endpoints (i.e., improvement in immune function) that will lead to a publishable paper. These studies used animals from the Obese NHP Resource. Progress: These studies have been completed.
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会议论文
PROJECT 1: METABOLIC AND NEUROENDOCRINE RESPONSES TO ANDROGEN AND DIET
-
批准号:8510085
-
项目类别:
-
资助金额:$24.89万
-
财政年份:2013
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL HIGH FAT DIET AND THE MELANOCORTIN SYSTEM IN THE OFFSPRING
-
批准号:8357879
-
项目类别:
-
资助金额:$4.36万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
GESTATIONAL DIABETES LEADS TO CARDIOVASCULAR VULNERABILITY IN OFFSPRING
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批准号:8357786
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
TREATMENT OF OBESITY AND INSULIN RESISTANCE IN THE NON-HUMAN PRIMATE
-
批准号:8357811
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
ACTIONS OF MELANOCORTIN AGONISTS IN OBESE PRIMATES
-
批准号:8357859
-
项目类别:
-
资助金额:$7.28万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
Molecular mechanisms underlying NHP pancreatic beta cell failure, and recovery
-
批准号:8214751
-
项目类别:
-
资助金额:$50.21万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE
-
批准号:8357764
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL DIET MODIFIES THE FETAL PRIMATE EPIGENOME AND CIRCADIAN GENE EXPRESSION
-
批准号:8357765
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
NEUROENDOCRINE RESPONSE TO GASTRIC BYPASS IN NONHUMAN PRIMATES
-
批准号:8357861
-
项目类别:
-
资助金额:$7.28万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
HIGH FAT DIET INDUCED ALTERATIONS IN GENE EXPRESSION IN THE NONHUMAN PRIMATE
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批准号:8357812
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL HIGH FAT DIET AND THE MELANOCORTIN SYSTEM IN THE OFFSPRING
-
批准号:8357766
-
项目类别:
-
资助金额:$7.28万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
THE IMPACT OF MATERNAL HEALTH AND DIET ON DEVELOPMENT OF FETAL METABOLIC SYSTEMS
-
批准号:8357860
-
项目类别:
-
资助金额:$10.91万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL HYPERINSULINEMIA AND FETAL PROGRAMMING
-
批准号:8357810
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
INVOLVEMENT OF THE MELANOCORTIN SYSTEM IN REGUL OF LIPOLYSIS & BLOOD PRESSURE
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批准号:8357858
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:KEVIN L GROVE
-
依托单位:
CARDIOVASCULAR DISEASE AND MICROVASCULAR DYSFUNCTION IN FAT-FED RHESUS MONKEYS
-
批准号:8173225
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL DIET MODIFIES THE FETAL PRIMATE EPIGENOME AND CIRCADIAN GENE EXPRESSION
-
批准号:8173227
-
项目类别:
-
资助金额:$7.61万
-
财政年份:2010
-
负责人:KEVIN L GROVE
-
依托单位:
OBESE NONHUMAN PRIMATE RESOURCE
-
批准号:8173284
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:KEVIN L GROVE
-
依托单位:
EFFICACY OF A MELANOCORTIN AGONIST ON ENERGY BALANCE AND GLYCEMIC CONTROL IN OB
-
批准号:8173229
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL HIGH FAT DIET PROGRAMS VASCULAR PATHOLOGY IN INFANTS
-
批准号:8173252
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:KEVIN L GROVE
-
依托单位:
MATERNAL HYPERINSULINEMIA AND FETAL PROGRAMMING
-
批准号:8173302
-
项目类别:
-
资助金额:$5.71万
-
财政年份:2010
-
负责人:KEVIN L GROVE
-
依托单位:
海外基金