THE EFFECT OF HUMANIZED ANTIBODIES TO ANGPTL4 ON TRIGLYERIDES & VLDL-LEVELS

ANGPTL4 人源化抗体对甘油三酯的影响

• 批准号: 8357857
• 负责人: KEVIN L GROVE
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357857
• 关键词: Animals; Antibodies; Coronary heart disease; Development; Diabetes Mellitus; Dyslipidemias; Enzymes; Funding; Future; Grant; Hypertriglyceridemia; Investigation; Lead; National Center for Research Resources; Obesity; Paper; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Risk Factors; Source; Testing; United States National Institutes of Health; Very low density lipoprotein; blood glucose regulation; cost; humanized antibody; immune function; improved; lipoprotein lipase; nonhuman primate; very low density lipoprotein triglyceride

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High levels of triglycerides and VLDL (also known as dyslipidemia) are widely accepted to be a major risk factor in the development of coronary heart disease and diabetes. This study tested the ability humanized ANGPTL4 antibodies to increase triglyceride clearance through activation of the lipoprotein lipase enzyme. In this proof of principle study we determined whether these antibodies can effectively reduce triglycerides and VLDL and improve glucose homeostasis in obese nonhuman primates. These studies will be expanded in the future to investigate prolonged treatment and investigation of other endpoints (i.e., improvement in immune function) that will lead to a publishable paper. These studies used animals from the Obese NHP Resource. Progress: These studies have been completed.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 高水平的甘油三酸酯和VLDL（也称为血脂异常）被广泛认为是冠心病和糖尿病发展的主要危险因素。这项研究测试了通过激活脂蛋白脂肪酶来增加甘油三酸酯清除率的能力。 在这项原则研究证明中，我们确定了这些抗体是否可以有效地减少甘油三酸酯和VLDL并改善肥胖非人类灵长类动物中的葡萄糖稳态。 这些研究将在未来扩大，以研究将导致可发表论文的其他终点的长期治疗和研究（即，免疫功能的改善）。这些研究使用了来自肥胖NHP资源的动物。 进度：这些研究已经完成。