NEUROENDOCRINE RESPONSE TO GASTRIC BYPASS IN NONHUMAN PRIMATES

非人类灵长类动物胃绕道的神经内分泌反应

• 批准号: 8357861
• 负责人: KEVIN L GROVE
• 金额: $ 7.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357861
• 关键词: Affect; Blood; Body Weight; Body Weight decreased; Body fat; Brain; Cell Nucleus; Diabetes Mellitus; Diet; Eating; Energy Metabolism; Epidemic; Fatty acid glycerol esters; Feeding behaviors; Food Energy; Food Preferences; Funding; Gastric Bypass; Gene Expression; Grant; Health; Human; Hypothalamic structure; Islets of Langerhans; Liver; Macaca mulatta; Metabolic; Metabolic Diseases; Modeling; Muscle; National Center for Research Resources; Neurosecretory Systems; Obesity; Peripheral; Phenotype; Physiological; Primates; Principal Investigator; Regulation; Research; Research Infrastructure; Resources; Rodent; Source; System; United States National Institutes of Health; Venous; Weight Gain; Work; blood glucose regulation; cost; energy balance; nonhuman primate; operation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Obesity is a worldwide health epidemic. Among the current therapies for obesity is Roux-en-Y gastric bypass (RYGB), which has proven to be very effective. Recent studies have revealed, unexpectedly, that RYGB works primarily by altering the physiological control of energy balance and body fat storage. It affects a wide variety of physiological systems, including the regulation of ingestive behavior, energy expenditure and glucose homeostasis. Moreover, the beneficial effects of this operation on diabetes and other metabolic disorders appear to include mechanisms independent of weight loss or diminished food intake. For such studies, we are examining the physiological effects of RYGB in the Rhesus macaque, a species of NHP that, like many humans, is susceptible to the weight gain and diabetes-promoting effects of a high fat diet. The aims of the project are (1) to establish a model of RYGB in obese Rhesus macaques and to characterize its effects on food intake, ingestive behavior, food preference and energy expenditure, phenotypes that appear highly responsive to RYGB in humans and rodents; (2) to characterize the effects of RYGB on glucose homeostasis and determine the mechanisms of these effects and the degree to which they are dependent on changes in food intake or body weight; (3) to characterize the effect of RYGB on the hypothalamic circuitry regulating ingestive behavior and energy balance; and (4) to examine the broad metabolic response to RYGB through gene expression and metabolic profiling of peripheral and portal venous blood, selected brain nuclei, pancreatic islets, liver and muscle.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 肥胖是全球健康流行病。当前的肥胖疗法包括roux-en-y胃旁路（RYGB），事实证明这非常有效。最近的研究表明，RYGB主要是通过改变能量平衡和体内脂肪储存的生理控制来工作。它影响了多种生理系统，包括对摄入行为，能量消耗和葡萄糖稳态的调节。此外，此手术对糖尿病和其他代谢疾病的有益作用似乎包括与体重减轻或食物摄入减少的机制。在此类研究中，我们正在研究RYGB在恒河猴中的生理影响，这种NHP像许多人一样容易受到高脂饮食的体重增加和糖尿病促进作用的影响。该项目的目的是（1）在肥胖的恒河猕猴中建立RYGB模型，并表征其对食物摄入，摄取行为，食物偏好和能量消耗的影响，对人类和啮齿动物中RYGB的反应性高度响应的表型； （2）表征RYGB对葡萄糖稳态的影响，并确定这些作用的机制以及它们取决于食物摄入或体重变化的程度； （3）表征RYGB对调节摄入行为和能量平衡的下丘脑电路的影响； （4）通过基因表达和外围和门户静脉血液的基因表达和代谢分析检查对RYGB的广泛代谢反应，选择的脑核，胰岛，肝脏和肌肉。