HIGH FAT DIET INDUCED ALTERATIONS IN GENE EXPRESSION IN THE NONHUMAN PRIMATE
高脂肪饮食引起非人类灵长类动物基因表达的改变
基本信息
- 批准号:8357812
- 负责人:
- 金额:$ 3.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:BrainClinicalClinical ResearchCommunitiesCoronary heart diseaseDataDatabasesDietEpidemicFatty LiverFatty acid glycerol estersFunctional disorderFundingFutureGene ExpressionGrantHealthHumanHypothalamic structureLiver diseasesMetabolicMetabolic DiseasesModelingNational Center for Research ResourcesNon-Insulin-Dependent Diabetes MellitusObesityObesity associated diseasePathogenesisPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesRodentRodent ModelScientistSourceSystemTranslationsUnited States National Institutes of Healthcosthypertensive heart diseaseinsightnonhuman primatenovelprotein expressionresearch studytherapeutic development
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Obesity is a worldwide health epidemic and a major contributor to the increased occurrence of coronary heart disease, hypertension, fatty liver disease, and type 2 diabetes. Both clinical research and studies in rodent models have provided key insights into the pathogenesis of obesity and associated disease, as well as the impact on the brain. However, both of these models have limitations that don't always allow for direct translation. The nonhuman primate (NHP) model has emerged as being critical for integrating observations from rodent and human studies. These studies will investigate changes in metabolic systems in the NHP model caused by high fat diet induced obesity (DIO). The specific purposes of this proposal are to characterize changes in gene and protein expression levels within the hypothalamus associated with obesity in the NHP. While these studies are primarily descriptive and correlative, this information will provide a critical database for the general scientific community and will allow both clinical and basic scientist to generate novel specific hypothesis about systems within the brain that become dysfunction is association with obesity. These data will also provide key insights for the future development of therapeutics for the treatment of metabolic diseases.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KEVIN L GROVE的其他文献
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{{ truncateString('KEVIN L GROVE', 18)}}的其他基金
PROJECT 1: METABOLIC AND NEUROENDOCRINE RESPONSES TO ANDROGEN AND DIET
项目 1:雄激素和饮食的代谢和神经内分泌反应
- 批准号:
8510085 - 财政年份:2013
- 资助金额:
$ 3.63万 - 项目类别:
MATERNAL HIGH FAT DIET AND THE MELANOCORTIN SYSTEM IN THE OFFSPRING
母亲的高脂肪饮食和后代的黑皮质素系统
- 批准号:
8357879 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
GESTATIONAL DIABETES LEADS TO CARDIOVASCULAR VULNERABILITY IN OFFSPRING
妊娠期糖尿病导致后代心血管脆弱
- 批准号:
8357786 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
TREATMENT OF OBESITY AND INSULIN RESISTANCE IN THE NON-HUMAN PRIMATE
非人类灵长类动物肥胖和胰岛素抵抗的治疗
- 批准号:
8357811 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
ACTIONS OF MELANOCORTIN AGONISTS IN OBESE PRIMATES
黑皮质素激动剂对肥胖灵长类动物的作用
- 批准号:
8357859 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
Molecular mechanisms underlying NHP pancreatic beta cell failure, and recovery
NHP 胰腺 β 细胞衰竭和恢复的分子机制
- 批准号:
8214751 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
THE EFFECT OF HUMANIZED ANTIBODIES TO ANGPTL4 ON TRIGLYERIDES & VLDL-LEVELS
ANGPTL4 人源化抗体对甘油三酯的影响
- 批准号:
8357857 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE
非人灵长类动物胎儿肝脏编程机制
- 批准号:
8357764 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
MATERNAL DIET MODIFIES THE FETAL PRIMATE EPIGENOME AND CIRCADIAN GENE EXPRESSION
母亲饮食改变胎儿灵长类表观基因组和昼夜节律基因表达
- 批准号:
8357765 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
NEUROENDOCRINE RESPONSE TO GASTRIC BYPASS IN NONHUMAN PRIMATES
非人类灵长类动物胃绕道的神经内分泌反应
- 批准号:
8357861 - 财政年份:2011
- 资助金额:
$ 3.63万 - 项目类别:
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