HIGH FAT DIET INDUCED ALTERATIONS IN GENE EXPRESSION IN THE NONHUMAN PRIMATE

高脂肪饮食引起非人类灵长类动物基因表达的改变

• 批准号: 8357812
• 负责人: KEVIN L GROVE
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357812
• 关键词: Brain; Clinical; Clinical Research; Communities; Coronary heart disease; Data; Databases; Diet; Epidemic; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Funding; Future; Gene Expression; Grant; Health; Human; Hypothalamic structure; Liver diseases; Metabolic; Metabolic Diseases; Modeling; National Center for Research Resources; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obesity associated disease; Pathogenesis; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rodent; Rodent Model; Scientist; Source; System; Translations; United States National Institutes of Health; cost; hypertensive heart disease; insight; nonhuman primate; novel; protein expression; research study; therapeutic development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Obesity is a worldwide health epidemic and a major contributor to the increased occurrence of coronary heart disease, hypertension, fatty liver disease, and type 2 diabetes. Both clinical research and studies in rodent models have provided key insights into the pathogenesis of obesity and associated disease, as well as the impact on the brain. However, both of these models have limitations that don't always allow for direct translation. The nonhuman primate (NHP) model has emerged as being critical for integrating observations from rodent and human studies. These studies will investigate changes in metabolic systems in the NHP model caused by high fat diet induced obesity (DIO). The specific purposes of this proposal are to characterize changes in gene and protein expression levels within the hypothalamus associated with obesity in the NHP. While these studies are primarily descriptive and correlative, this information will provide a critical database for the general scientific community and will allow both clinical and basic scientist to generate novel specific hypothesis about systems within the brain that become dysfunction is association with obesity. These data will also provide key insights for the future development of therapeutics for the treatment of metabolic diseases.

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