MATERNAL HIGH FAT DIET AND THE MELANOCORTIN SYSTEM IN THE OFFSPRING

母亲的高脂肪饮食和后代的黑皮质素系统

• 批准号: 8357879
• 负责人: KEVIN L GROVE
• 金额: $ 4.36万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357879
• 关键词: Body Weight; Child; Consumption; Development; Diabetes Mellitus; Diet; Discipline of Nursing; Eating; Fatty acid glycerol esters; Feedback; Food Energy; Funding; Grant; Health; Homeostasis; Hypothalamic structure; Long-Term Effects; Metabolic; Metabolic Diseases; Modeling; National Center for Research Resources; Neonatal; Neurons; Obesity; Overweight; Peripheral; Phenotype; Pregnancy; Prevention; Primates; Principal Investigator; Public Health; Research; Research Infrastructure; Resources; Signal Transduction; Source; System; United States; United States National Institutes of Health; cost; design; diabetic; early onset; energy balance; feeding; fetal; good diet; neuron development; nonhuman primate; obesity in children; offspring; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Over the past several decades there has been a dramatic increase in childhood obesity. The general hypothesis of this proposal is that diet and metabolic health during pregnancy and the early neonatal period significantly contribute to the development of metabolic diseases in children. For these studies we developed a nonhuman primate (NHP) model of high fat/calorie diet-induced maternal obesity/diabetes that is allowing us to determine the immediate and long-term effects on body weight homeostasis in offspring. The specific focus of this proposal is the melanocortin neurons in the hypothalamus, which are critical for the homoeostatic feedback control of food intake and energy balance in response to peripheral adiposity signals. We predicted that consumption of a high fat/calorie diet during pregnancy and during nursing will cause an abnormal development of these neurons during in the fetal period, leading to a long-term reprogramming. With these developmental abnormalities, we expect the offspring to be predisposed to early onset obesity and ultimately diabetes. Finally, we will determine if feeding a healthy diet to obese/diabetic NHPs specifically during pregnancy is protective against the development of metabolic abnormalities in the offspring. With these studies, we hope to demonstrate that simply being overweight and eating a high fat diet causes metabolic disease in babies; a maternal phenotype that matches the majority of pregnancies in the United States. This information will be critical for designing a viable prevention and has enormous public health implications.

这个子项目是利用这些资源的众多研究子项目之一