MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE

非人灵长类动物胎儿肝脏编程机制

• 批准号: 8357764
• 负责人: KEVIN L GROVE
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357764
• 关键词: Animals; Development; Diet; Fatty acid glycerol esters; Funding; Gluconeogenesis; Grant; Health; Hepatic; Lipolysis; Liver; Metabolic; Muscle; National Center for Research Resources; Pathway interactions; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Sampling; Source; System; United States National Institutes of Health; cost; fetal; insulin signaling; lipid biosynthesis; nonhuman primate; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall purpose of this project is to determine the effect of maternal high fat/calorie diet and metabolic health on the developmental programming of metabolic systems in the liver and muscle. These studies are focusing on the reprogramming of the insulin signaling, lipogenesis/lipolysis, and gluconeogenesis pathways. Our role in these studies is primarily supportive through assistance with the animal management and obtaining samples.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的总体目的是确定母体高脂肪/热量饮食和代谢健康对肝脏和肌肉代谢系统发育规划的影响。这些研究集中在胰岛素信号转导、脂肪生成/脂解和脂肪生成途径的重编程上。我们在这些研究中的作用主要是通过协助动物管理和获取样本来提供支持。