MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE

非人灵长类动物胎儿肝脏编程机制

• 批准号: 8357764
• 负责人: KEVIN L GROVE
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357764
• 关键词: Animals; Development; Diet; Fatty acid glycerol esters; Funding; Gluconeogenesis; Grant; Health; Hepatic; Lipolysis; Liver; Metabolic; Muscle; National Center for Research Resources; Pathway interactions; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Sampling; Source; System; United States National Institutes of Health; cost; fetal; insulin signaling; lipid biosynthesis; nonhuman primate; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall purpose of this project is to determine the effect of maternal high fat/calorie diet and metabolic health on the developmental programming of metabolic systems in the liver and muscle. These studies are focusing on the reprogramming of the insulin signaling, lipogenesis/lipolysis, and gluconeogenesis pathways. Our role in these studies is primarily supportive through assistance with the animal management and obtaining samples.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目的总体目的是确定母体高脂肪/卡路里饮食和代谢健康对肝脏和肌肉代谢系统发展编程的影响。这些研究重点是重编程胰岛素信号传导，脂肪生成/脂解和糖异生途径。我们在这些研究中的作用主要是通过协助动物管理和获取样本来支持。