National Biomedical NMR Resource at Madison

麦迪逊国家生物医学 NMR 资源

• 批准号: 8035947
• 负责人: JOHN LUTE MARKLEY
• 金额: $ 102.79万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8035947
• 关键词: National; Biomedical; NMR; Resource; Madison

The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource for biomolecular nuclear magnetic resonance (NMR) spectroscopy. NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) highthroughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, including complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches to metabolomics and natural product analysis. NMRFAM strives to be a model to the larger biological community for cutting-edge capabilities of NMR spectroscopy. With the goal of broadening the scope of its scientific activities, NMRFAM hosts distinguished visiting scientists working in areas related to its research technology and development projects. NMRFAM develops and disseminates advanced approaches that cover all steps in biomolecular NMR investigations and offers start-to-finish support for biomedical NMR investigations with assistance in one or more of the following steps: (1) strategy evaluation and experiment design, (2) sample preparaton, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data validation and deposition, and (7) manuscript preparation. NMRFAM provides researchers with resources matched to their particular needs in their search for new knowledge. A major goal is to develop methods for making these investigations faster and less costly as well as applicable to larger classes of proteins and nucleic acids of importance in human health. NMRFAM provides young investigators and experienced spectroscopists access to state-of-the-art instrumentation with support for multiple modes of data collection either as service or collaborative projects. Protocols, pulse sequences, software tools, and databases developed through NMRFAM's research activities are made available to the general scientific community. Users receive hands-on training at the center. As another means for training its user base and for disseminating its novel technology, NMRFAM conducts annual workshops and group training sessions. Additional mechanisms used to disseminate NMRFAM technology include quarterly newsletters, the NMRFAM website, software servers, a metabolomics database, presentations at meetings, and the publication of articles and reviews.

位于麦迪逊的国家磁共振设施（NMRFAM）是生物分子核的资源。 磁共振（NMR）光谱。NMRFAM旨在拓展生物分子NMR的前沿 光谱通过资源技术和发展计划的重要领域（1）高通量 确定较小蛋白质和RNA分子的结构和功能，（2）技术 用于研究具有挑战性的系统的结构和动力学，包括复合物，膜 蛋白质，顺磁性蛋白质和较大的RNA分子，以及（3）代谢组学的有效方法， 天然产物分析NMRFAM致力于成为更大的生物界的前沿模型 NMR光谱的能力。为了扩大其科学活动的范围， NMRFAM主办杰出的访问科学家在其研究技术相关领域的工作， 发展项目。NMRFAM开发和传播涵盖所有步骤的先进方法， 生物分子核磁共振研究，并为生物医学核磁共振研究提供从头到尾的支持， 协助以下一个或多个步骤：（1）策略评估和实验设计，（2）样本 论证，（3）可行性研究，（4）数据收集，（5）数据分析和结构确定，（6） 验证和沉积，和（7）手稿准备。NMRFAM为研究人员提供资源 以满足他们寻求新知识的特殊需求。一个主要目标是开发方法， 使这些研究更快，成本更低，并适用于更大类别的蛋白质， 核酸对人类健康的重要性。NMRFAM提供年轻的研究人员和经验丰富的 光谱分析师可以使用最先进的仪器，支持多种数据收集模式 无论是服务项目还是合作项目。开发的方案、脉冲序列、软件工具和数据库 通过NMRFAM的研究活动，向一般科学界提供。用户收到 在中心进行实践培训。作为培训其用户基础和传播其小说的另一种手段， 在技术方面，国家小额信贷和小额贷款促进机构每年举办讲习班和集体培训班。使用的其他机制 传播NMRFAM技术，包括季度通讯，NMRFAM网站，软件服务器， 代谢组学数据库，会议上的演讲，以及文章和评论的出版。