National Biomedical NMR Resource at Madison

麦迪逊国家生物医学 NMR 资源

• 批准号: 9010561
• 负责人: JOHN LUTE MARKLEY
• 金额: $ 56.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9010561
• 关键词: Area; Automation; Automobile Driving; Binding; Biological; Biological Factors; Biomolecular Nuclear Magnetic Resonance; Cell Extracts; Chemicals; Communities; Complex; Computer software; Consult; Data; Data Analyses; Data Collection; Databases; Deposition; Documentation; Educational workshop; Environmental Risk Factor; Evaluation; Feasibility Studies; Genetic; Goals; Health; Human; Human Resources; Investigation; Knowledge; Label; Liquid Chromatography; Liquid substance; Magnetic Resonance; Manuscripts; Membrane Proteins; Methodology; Methods; Modeling; NMR Spectroscopy; Newsletter; Nuclear Magnetic Resonance; Nucleic Acids; Pharmaceutical Preparations; Physiologic pulse; Preparation; Process; Production; Proteins; Protocols documentation; Publications; Qualifying; RNA; Recovery; Research; Research Activity; Research Personnel; Resources; Sampling; Scientist; Services; Site; Software Tools; Solutions; Structure; System; Technology; Tissues; Training; Validation; Visit; Work; base; biological systems; cost; data structure; design; experience; frontier; high throughput analysis; instrumentation; lectures; meetings; metabolomics; molecular dynamics; new technology; novel; posters; programs; protein complex; protein structure; research and development; research study; screening; small molecule; software development; technology development; three dimensional structure; tool; web site

The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource for biomolecular nuclear magnetic resonance (NMR) spectroscopy. NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high-throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, including complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches to metabolomics and natural product analysis. NMRFAM strives to be a model to the larger biological community for cutting-edge capabilities of NMR spectroscopy. With the goal of broadening the scope of its scientific activities, NMRFAM hosts distinguished visiting scientists working in areas related to its research technology and development projects. NMRFAM develops and disseminates advanced approaches that cover all steps in biomolecular NMR investigations and offers start-to-finish support for biomedical NMR investigations with assistance in one or more of the following steps: (1) strategy evaluation and experiment design, (2) sample preparaton, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data validation and deposition, and (7) manuscript preparation. NMRFAM provides researchers with resources matched to their particular needs in their search for new knowledge. A major goal is to develop methods for making these investigations faster and less costly as well as applicable to larger classes of proteins and nucleic acids of importance in human health. NMRFAM provides young investigators and experienced spectroscopists access to state-of-the-art instrumentation with support for multiple modes of data collection either as service or collaborative projects. Protocols, pulse sequences, software tools, and databases developed through NMRFAM's research activities are made available to the general scientific community. Users receive hands-on training at the center. As another means for training its user base and for disseminating its novel technology, NMRFAM conducts annual workshops and group training sessions. Additional mechanisms used to disseminate NMRFAM technology include quarterly newsletters, the NMRFAM website, software servers, a metabolomics database, presentations at meetings, and the publication of articles and reviews.

位于麦迪逊的国家磁共振设施(NMRFAM)是生物分子核磁共振(核磁共振)波谱的资源。NMRFAM旨在通过资源技术和开发计划在以下重要领域扩大生物分子核磁共振波谱的前沿：(1)高通量确定较小蛋白质和RNA分子的结构和功能；(2)研究具有挑战性的系统的结构和动力学技术，包括复合体、膜蛋白质、顺磁性蛋白质和较大RNA分子；以及(3)代谢组学和天然产物分析的有效方法。NMRFAM致力于成为更大的生物界核磁共振波谱尖端能力的典范。为了扩大其科学活动的范围，NMRFAM接待了与其研究技术和开发项目相关领域工作的杰出来访科学家。NMRFAM开发和传播涵盖生物分子核磁共振研究所有步骤的先进方法，并在以下一个或多个步骤中提供从头到尾的生物医学核磁共振研究支持：(1)策略评估和实验设计，(2)样品准备，(3)可行性研究，(4)数据收集，(5)数据分析和结构确定，(6)数据验证和沉积，以及(7)手稿准备。NMRFAM为研究人员提供了与他们在寻找新知识方面的特定需求相匹配的资源。一个主要目标是开发方法，使这些调查更快、成本更低，并适用于对人类健康具有重要意义的更大类别的蛋白质和核酸。NMRFAM为年轻的研究人员和经验丰富的光谱学家提供访问最先进的仪器的途径，并支持多种数据收集模式，无论是作为服务还是合作项目。通过NMRFAM的研究活动开发的协议、脉冲序列、软件工具和数据库可供一般科学界使用。用户在该中心接受实践培训。作为培训其用户基础和传播其新技术的另一种手段，NMRFAM每年举办讲习班和小组培训班。用于传播NMRFAM技术的其他机制包括季度通讯、NMRFAM网站、软件服务器、代谢组学数据库、会议演示以及发表文章和评论。