EXPOSURE FACILITY

项目概述（见说明）：暴露设施的目标是提供一个高度专业化的共享资源，以支持纽约大学洛杉矶分校成员在致癌模型和管理方面的动物暴露研究的科学需求，以及在动物和人类样本中测量暴露的分析化学。在上一次竞争性更新中，实验动物和暴露设施由两个综合单元组成，即动物护理和暴露单元和吸入暴露单元，它们为啮齿类动物提供专门的动物护理和技术援助，这些实验涉及致癌和有毒化学物质的激发实验，或通过吸入、全身、皮肤和口服等各种暴露途径进行化学预防/化疗。这些针对动物暴露的独特服务在纽索特派团的其他地方是没有的。近年来，正在进行的动物和人类接触研究正在调查金属的影响，金属通常与吸入的空气污染颗粒物或纳米颗粒有关。为了有效地满足纽约大学研究人员对金属分析不断发展的研究需求，金属分析经常涉及专门的啮齿动物吸入致癌金属，环境空气污染或人造颗粒大气，其中许多由金属纳米颗粒组成，分析化学共享资源，自1975年以来以前是一个独立的共享资源，现在被合并为实验动物和暴露设施内的分析化学单元。分析化学单位将继续为纽格尔研究人员提供常规的原子吸收（AA）和x射线荧光（XRF）光谱，以定性和定量测定生物和环境样品中的金属含量。这个新合并的共享资源命名为

PROJECT SUMMARY (See instructions): The objective of the Exposure Facility is to provide a highly specialized shared resource to support the scientific needs of NYUCI members for animal exposure research in carcinogenesis models and administration, as well as analytical chemistry to measure exposure in both animal and human samples. In the last competing renewal, the Experimental Animal and Exposure Facility consisted of two integrated units, the Animal Care and Exposure Unit and the Inhalation Exposure Unit, which provide specialized animal care, technical assistance for experiments with rodent species involving delivery of carcinogenic and toxic chemicals for challenge experiments, or chemoprevention/chemotherapy via various routes of exposure including inhalation, systemic, dermal, and oral administration. These unique services for animal exposure are not offered elsewhere at NYUSOM. In recent years, the influences of metals, often associated with inhaled air pollution particulate matter or nanoparticles, are being investigated In ongoing studies in animal and human exposures. To effectively meet the evolving research needs of NYUCI Investigators for metal analyses which frequently involve specialized rodent inhalation exposures to carcinogenic metals, ambient air pollution or contrived particulate atmospheres, many of which are comprised of metal nanoparticles, the Analytical Chemistry Shared Resource, a previously stand-alone shared resource since 1975, Is now incorporated as the Analytical Chemistry Unit within the Experimental Animal and Exposure Facility. The Analytical Chemistry Unit will continue to provide NYUGl investigators with routine access to Atomic Absorption (AA) and X-Ray Fluorescence (XRF) spectroscopy for the qualitative and quantitative determination of metal content in biological and environmental samples. This newly merged shared resource entitled the