perfluorooctanoic acid in laboratory animals for the National Toxicology Program

本项目的目的是评估全氟辛酸(PFOA)对饮食中暴露的大鼠的慢性毒性和致癌性。全氟辛烷磺酸被用作泡沫灭火剂中的表面活性剂，并用于生产不粘和防污渍产品，并且在环境中持续存在。目前正在完成为期两年的慢性毒性和致癌性研究报告。这些研究包括围产期暴露(孕期和哺乳期暴露)。人类很可能通过环境类似地接触到这些化合物。围产期暴露发生在发育的关键时期，与仅从成年期开始暴露相比，可能导致毒性/致癌性的差异。全氟辛烷磺酸研究包括围产期暴露和不暴露的两年暴露，以评估围产期暴露的影响。 关键词：毒性、致癌性、围产期、全氟辛酸

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of perfluorooctanoic acid (PFOA) in rats exposed in the diet. PFOA is used as a surfactant in foam fire-fighting agents and in the production of non-stick and stain-resistant products and is persistent in the environment. Reports for the 2-Year chronic toxicity and carcinogenicity studies currently being finalized. These studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. The PFOA studies include 2-year exposures in both with and without perinatal exposure, to evaluate the effect of perinatal exposure. Keywords: toxicity, carcinogenicity, perinatal, perfluorooctanoic acid