Research Training in Gastroenterology

描述(由申请人提供)：本次续签申请T32 DK067872，位于巴尔的摩马里兰大学的胃肠病研究培训，要求为3名博士后和5名博士后(MD，PhD，MD/PhD)学员提供为期5年的资金。该项目的总体目标保持不变；通过提供强调粘膜生物学和免疫学、细胞信号和增殖、肠道病原体和疫苗开发以及临床研究的综合跨学科课程，为GL的学术生涯寻找和培养有才华的学员。NIH拥有雄厚资金的医学院实体代表跨部门削减，包括内科、儿科、外科、微生物学和免疫学、生物化学和分子生物学以及流行病学和预防医学。基础广泛的培训机会允许博士后实习生获得博士或医学博士/博士学位，博士后实习生获得硕士、公共卫生硕士或博士学位。四个研究轨道(细胞信号与增殖、粘膜免疫学与微生物学、上皮细胞生物学、临床与翻译科学)由经验丰富的资深研究人员指导，并由在这些轨道内和之间互动的高生产率、经验丰富的导师组成。学员在拥有卓越导师和研究资质的教师的指导下，至少在实验室或患者为基础的研究中投入2年时间。在最初的资助阶段，该计划非常成功；所有的培训名额都被填满了，学员留存率达到100%，生产率也很高。两名完成培训的博士前T32实习生都有资格获得博士学位。在完成培训的8名博士后研究员中，4名正在完成临床培训，4名助理教授从事学术医学或儿科学的基础或临床研究(1名获得NIDDK K08奖支持，另一名尚未获得NIDDK K08奖)。这个T32项目非常多样化；在15名受训人员(2005-2010年)中，10名(66%)是女性；3名(20%)是非裔美国人；2名(13%)是西班牙裔。在过去的4年里，该计划通过增加有资金的、有生产力的、具有强大指导资质的教师，以及创新(例如，增加初级教师成员，以“指导未来的导师”，以及为临床医生提供博士课程)来成熟和发展。 与公共卫生相关：竞争日益激烈的研究资金和有利可图的实践机会阻碍了受训人员从事胃肠病研究。该计划的总体目标是通过提供基础和临床消化疾病相关研究的综合、跨学科、个性化的课程，寻找和培养有才华的博士后和博士后实习生，为胃肠病学的学术生涯做准备。

DESCRIPTION (provided by applicant): This renewal application for T32 DK067872, Research Training in Gastroenterology at the University of Maryland, Baltimore, requests 5 yrs of funding for 3 predoctoral and 5 postdoctoral (MD, PhD, MD/PhD) trainees. Overall goals of this program are unchanged; to seek and prepare talented trainees for academic careers in Gl by offering an integrated, Interdisciplinary curriculum that emphasizes mucosal biology & immunology, cell signaling & proliferation, enteric pathogens & vaccine development, and clinical research. School of Medicine entities represented by faculty with strong NIH funding cut across departmental lines to include Medicine, Pediatrics, Surgery, Microbiology & Immunology, Biochemistry & Molecular Biology, and Epidemiology & Preventive Medicine. Broad-based training opportunities allow predoctoral trainees to obtain PhD or MD/PhD degrees and postdoctoral trainees to earn MS, MPH or PhD degrees. Four research tracks (Cell Signaling & Proliferation, Mucosal Immunology & Microbiology, Epithelial Cell Biology, and Clinical & Translational Science) are directed by accomplished senior investigators and comprised of highly productive, experienced mentors who interact both within and amongst these tracks. Trainees devote a minimum of 2 yrs in lab- or patient-based research guided by faculty with exceptional mentorship and research credentials. In its initial period of funding, the program was highly successful; all training slots were filled, trainee retention was 100%, and productivity was outstanding. Both predoctoral T32 trainees who completed training qualified for the PhD degree. Of 8 postdoctoral fellows completing training, 4 are completing clinical training and 4 are Assistant Professors pursuing basic or clinical research in academic Medicine or Pediatrics (1 supported by and another with pending NIDDK K08 awards). This T32 program is extraordinarily diverse; of 15 trainees (2005-10), 10 (66%) are women; 3 (20%) are African American; and 2 (13%) are Hispanic. During the past 4 years, the program matured and grew by adding funded, productive faculty with strong mentoring credentials, and by innovation (e.g. adding Junior Faculty members, to 'mentor future mentors', and offering a Ph.D. Program for Clinicians). PUBLIC HEALTH RELEVANCE: Increasingly competitive research funding and lucrative practice opportunities discourage trainees from careers in gastroenterology research. The overall goal of this program is to seek and nurture talented pre- and postdoctoral trainees preparing for academic careers in gastroenterology by offering an integrated, interdisciplinary, individualized curriculum in both basic and clinical digestive diseases-related research.