Research Training in Gastroenterology

描述（由申请人提供）：T32 DK 067872（位于巴尔的摩的马里兰州大学胃肠病学研究培训）的更新申请要求为3名博士前和5名博士后（MD、PhD、MD/PhD）学员提供5年的资助。该计划的总体目标是不变的;通过提供综合的跨学科课程，强调粘膜生物学和免疫学，细胞信号传导和增殖，肠道病原体和疫苗开发以及临床研究，为GI的学术生涯寻找和准备有才华的学员。由NIH资助的教师代表的医学院实体跨越部门线，包括医学，儿科学，外科学，微生物学和免疫学，生物化学和分子生物学，流行病学和预防医学。基础广泛的培训机会使博士前学员获得博士或MD/博士学位，博士后学员获得MS，MPH或博士学位。四个研究轨道（细胞信号传导与增殖，粘液免疫学与微生物学，上皮细胞生物学和临床与转化科学）由资深研究人员指导，并由富有成效，经验丰富的导师组成，他们在这些轨道内和轨道之间进行互动。受训者至少在实验室或基于患者的研究中投入2年，由具有特殊指导和研究资格的教师指导。在最初的资助阶段，该计划非常成功;所有的培训名额都被填满，学员保留率为100%，生产力也非常出色。完成培训的两名博士前T32学员都有资格获得博士学位。在完成培训的8名博士后研究员中，4名正在完成临床培训，4名是从事学术医学或儿科学基础或临床研究的助理教授（1名获得NIDDK K 08奖的支持，另一名获得NIDDK K 08奖）。该T32方案非常多样化;在15名受训人员（2005- 2010年）中，10名（66%）是妇女; 3名（20%）是非洲裔美国人; 2名（13%）是西班牙裔。在过去的4年里，该计划成熟和增长，增加了资金，生产力教师与强大的指导证书，并通过创新（例如，增加初级教师，以“导师未来的导师”，并提供博士学位。临床医生）。 公共卫生相关性：越来越多的竞争性研究资金和有利可图的实践机会阻止实习生从事胃肠病学研究。该计划的总体目标是通过提供基础和临床消化系统疾病相关研究的综合，跨学科，个性化课程，寻求和培养有才华的博士前和博士后学员，为胃肠病学的学术生涯做准备。

DESCRIPTION (provided by applicant): This renewal application for T32 DK067872, Research Training in Gastroenterology at the University of Maryland, Baltimore, requests 5 yrs of funding for 3 predoctoral and 5 postdoctoral (MD, PhD, MD/PhD) trainees. Overall goals of this program are unchanged; to seek and prepare talented trainees for academic careers in Gl by offering an integrated, Interdisciplinary curriculum that emphasizes mucosal biology & immunology, cell signaling & proliferation, enteric pathogens & vaccine development, and clinical research. School of Medicine entities represented by faculty with strong NIH funding cut across departmental lines to include Medicine, Pediatrics, Surgery, Microbiology & Immunology, Biochemistry & Molecular Biology, and Epidemiology & Preventive Medicine. Broad-based training opportunities allow predoctoral trainees to obtain PhD or MD/PhD degrees and postdoctoral trainees to earn MS, MPH or PhD degrees. Four research tracks (Cell Signaling & Proliferation, Mucosal Immunology & Microbiology, Epithelial Cell Biology, and Clinical & Translational Science) are directed by accomplished senior investigators and comprised of highly productive, experienced mentors who interact both within and amongst these tracks. Trainees devote a minimum of 2 yrs in lab- or patient-based research guided by faculty with exceptional mentorship and research credentials. In its initial period of funding, the program was highly successful; all training slots were filled, trainee retention was 100%, and productivity was outstanding. Both predoctoral T32 trainees who completed training qualified for the PhD degree. Of 8 postdoctoral fellows completing training, 4 are completing clinical training and 4 are Assistant Professors pursuing basic or clinical research in academic Medicine or Pediatrics (1 supported by and another with pending NIDDK K08 awards). This T32 program is extraordinarily diverse; of 15 trainees (2005-10), 10 (66%) are women; 3 (20%) are African American; and 2 (13%) are Hispanic. During the past 4 years, the program matured and grew by adding funded, productive faculty with strong mentoring credentials, and by innovation (e.g. adding Junior Faculty members, to 'mentor future mentors', and offering a Ph.D. Program for Clinicians). PUBLIC HEALTH RELEVANCE: Increasingly competitive research funding and lucrative practice opportunities discourage trainees from careers in gastroenterology research. The overall goal of this program is to seek and nurture talented pre- and postdoctoral trainees preparing for academic careers in gastroenterology by offering an integrated, interdisciplinary, individualized curriculum in both basic and clinical digestive diseases-related research.