Research Training In Gastroenterology

 描述(由申请者提供)：此续签申请T32 DK067872，胃肠病学研究培训，在马里兰大学，巴尔的摩大学(UMB)要求为四名博士后和五名博士后(医学、博士、医学/博士)实习生提供五年的支持。课程目标不变：通过提供综合的跨学科课程，强调粘膜生物学和免疫学、细胞信号和增殖、肠道病原体和疫苗开发以及临床研究，为胃肠病学的学术生涯寻找和准备人才。以教师导师为代表的UMB实体在NIH的大力支持下横跨学校和系，包括医学院(内科、儿科、外科、流行病学和公共卫生、微生物学和免疫学、生物化学和分子生物学)和药学(药学系)。基础广泛的培训机会允许博士后实习生获得博士或医学博士/博士学位，博士后实习生获得硕士、公共卫生硕士或博士学位。在专家导师的监督下，培训计划旨在使学员能够开发假设，设计和执行基础或临床研究来检验这些假设，成为至少一个与消化系统疾病相关的实质性领域的专家，发展口头和书面陈述所需的技能，掌握负责任的研究行为原则，并为过渡到消化系统疾病的学术生涯做准备。三个研究轨道(粘膜免疫学和炎症；上皮细胞生物学和信号；临床和转化科学)由经验丰富的资深研究人员指导，并由高生产率的经验丰富的导师组成，他们在这些轨道内和之间进行互动。自2005年启动以来，这一T32项目一直非常成功，所有培训职位都得到了填补，学员留存率达到100%，工作效率出众。所有六名完成培训的博士前实习生都有资格获得博士学位。在目前的资助期间，12名博士后实习生中有8名(66%)已获得或即将获得高级学位(理科硕士、公共卫生硕士或博士)。这个T32项目仍然非常多样化；自项目开始以来，我们培训了33人，其中19人(58%)是妇女，6人(18%)是代表性不足的少数民族。在完成所有培训的16名博士后实习生中，13人(81%)获得了学术教师职位，两人成功竞争NIH基金(NIDDK K08奖)。在当前的资助周期中，该计划通过增加具有强大指导资质的有资金的、富有成效的教师和创新(例如，利用ABIM研究途径来识别和招募有前途的医学生，以指导T32资助的通向学术胃肠病学的途径，增加新的自我评估工具，并通过我们自己的一系列T32教师领导的研讨会加强负责任的研究行为指导)继续成熟和发展。我们还提供证据表明，这个T32项目通过吸引其他学科的研究人员参与与消化系统疾病相关的研究，为UMB科学界增加了巨大的价值。

 DESCRIPTION (provided by applicant): This renewal application for T32 DK067872, Research Training in Gastroenterology, at the University of Maryland, Baltimore (UMB) requests five years of support for four predoctoral and five postdoctoral (MD, PhD, MD/PhD) trainees. Program goals are unchanged: to seek and prepare talented trainees for academic careers in gastroenterology by offering an integrated, interdisciplinary curriculum that emphasizes mucosal biology & immunology, cell signaling & proliferation, enteric pathogens & vaccine development, and clinical research. UMB entities represented by faculty mentors with strong NIH support cut across schools and departments to include the Schools of Medicine (Departments of Medicine, Pediatrics, Surgery, Epidemiology & Public Health, Microbiology & Immunology, Biochemistry & Molecular Biology) and Pharmacy (Department of Pharmaceutical Sciences). Broad-based training opportunities allow predoctoral trainees to obtain PhD or MD/PhD degrees and postdoctoral trainees to earn MS, MPH or PhD degrees. Under the supervision of expert mentors, the training program is designed to enable trainees to develop hypotheses, design and perform basic or clinical research to test these hypotheses, become expert in at least one substantive area relevant to digestive diseases, develop skills needed for oral and written presentations, master the principles of responsible conduct of research, and prepare for transition to an academic career in digestive diseases. Three research tracks (Mucosal Immunology & Inflammation; Epithelial Cell Biology & Signaling; Clinical & Translational Science) are directed by accomplished senior investigators and comprised of highly productive experienced mentors who interact both within and amongst these tracks. Since its inception in 2005, this T32 program has been highly successful; all training slots were filled, trainee retention was 100%, and productivity was outstanding. All six predoctoral trainees who completed training qualified for the PhD degree. In the current funding period, eight of 12 postdoctoral trainees (66%) either received or are poised to receive advanced degrees (MS, MPH or PhD). This T32 program remains extraordinarily diverse; since its inception we trained 33 persons of whom 19 (58%) are women and 6 (18%) are underrepresented minorities. Of 16 postdoctoral trainees who completed all training, 13 (81%) have academic faculty appointments and two successfully competed for NIH funding (NIDDK K08 awards). During the current funding cycle, the program has continued to mature and grow by adding funded, productive faculty with strong mentoring credentials, and by innovation (e.g. leveraging the ABIM research pathway to identify and recruit promising medical students for mentored T32-sponsored pathways leading to academic gastroenterology, adding novel self-assessment tools, and enhancing instruction in Responsible Conduct of Research with our own series of T32 faculty-led seminars that address specific ethical issues). We also provide evidence that this T32 program adds great value to the UMB scientific community by attracting investigators from other disciplines to digestive disease-related research.