Dissecting the Fabric of the Cerebral Cortex

解剖大脑皮层的结构

基本信息

  • 批准号:
    8523898
  • 负责人:
  • 金额:
    $ 75.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-30 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

The cerebral cortex houses our mental functions like perception, cognition and action. Despite major advances in discovering the properties of single cells and molecular-level processes, we still do not know how the cortex works at the circuit level. The essence of the problem lies in understanding how the billions of neurons communicating through trillions of connections orchestrate their activities to give rise to our mental faculties. We are far from being able to simultaneously measure the activity of all the myriads of cortical cells and assemble their physical wiring diagram (connectome). However, if there are underlying principles and rules that govern this complexity, discovering these principles provides an obvious strategy for understanding how the cortex functions. Indeed, it has been hypothesized that the cortex is composed of elementary information processing modules. For almost a century anatomists have observed remarkable regularity in the cortical microarchitecture: strings of cells derived from a common progenitor cell and having a propensity of being synaptically connected are arranged to form small columns orthogonal to the cortical surface. These microcolumns are hypothesized to be the elementary functional units of cortical circuitry. If one were able to understand their organizing principles, the task of understanding how the cortex works would be simplified immensely. Discovering the function of these elementary modules would be analogous to the discovery of the gene, which ultimately led to the molecular revolution of the 20th century. So far, these structures could not be studied in detail due to technical limitations. To understand the function of a microcolumn, it is imperative to simultaneously monitor the activity of all its constituting neurons in vivo. It is our goal to overcome these technical challenges and develop in-vivo methods to study an entire microlumn. We propose to develop in vivo microscopy based on 3D random-access multi-photon (3D-RAMP) excitation. This tour de force microscope will employ a series of acousto-optical deflectors operating at long wavelengths that will generate any desired 3D scanning path at frame rates two orders of magnitude faster than current state-of-the-art two-photon imaging systems. This will allow simultaneous in-vivo recordings of the activity of an entire column of sister cells across all six cortical layers. The microscope will employ two 3D-RAMP scanners that will enable simultaneous recording and photostimulation of neural activity to assemble the functional connectivity diagram of the microcolumn. Viral and genetic methods will be used to identify and label ontogenetic microcolumns in vivo. Through collaboration their connectome will be assembled. We plan to create a database of the Microcolumn Architecture of the Cortex that will include functional, anatomical and ontogenetic information about the organization of microcolumns across cortical areas, species and animal models of diseases. Our proposal promises to unravel the elementary principles of how cortical circuits are organized to give rise to mental function. If we succeed our results will constitute a quantum leap in our quest to understand the brain.
大脑皮层容纳着我们的心理功能,比如感知、认知和行动。尽管在发现单细胞特性和分子水平过程方面取得了重大进展,但我们仍然不知道皮层在回路水平上是如何工作的。问题的本质在于理解数十亿神经元如何通过数万亿个连接进行交流,协调它们的活动,从而产生我们的心智能力。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Andreas Tolias其他文献

Andreas Tolias的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Andreas Tolias', 18)}}的其他基金

BRAIN CONNECTS: Synaptic resolution whole-brain circuit mapping of molecularly defined cell types using a barcoded rabies virus
大脑连接:使用条形码狂犬病病毒对分子定义的细胞类型进行突触分辨率全脑电路图谱
  • 批准号:
    10672786
  • 财政年份:
    2023
  • 资助金额:
    $ 75.9万
  • 项目类别:
Simultaneous high-throughput functional, transcriptomic and connectivity profiling using FUNseq
使用 FUNseq 同时进行高通量功能、转录组和连接分析
  • 批准号:
    10413650
  • 财政年份:
    2022
  • 资助金额:
    $ 75.9万
  • 项目类别:
A MOLECULAR CODE FOR CONNECTIVITY IN THE NEOCORTEX
新皮质连接的分子密码
  • 批准号:
    9109046
  • 财政年份:
    2013
  • 资助金额:
    $ 75.9万
  • 项目类别:
A MOLECULAR CODE FOR CONNECTIVITY IN THE NEOCORTEX
新皮质连接的分子密码
  • 批准号:
    8743292
  • 财政年份:
    2013
  • 资助金额:
    $ 75.9万
  • 项目类别:
A MOLECULAR CODE FOR CONNECTIVITY IN THE NEOCORTEX
新皮质连接的分子密码
  • 批准号:
    8639755
  • 财政年份:
    2013
  • 资助金额:
    $ 75.9万
  • 项目类别:
Dissecting the Fabric of the Cerebral Cortex
解剖大脑皮层的结构
  • 批准号:
    8331581
  • 财政年份:
    2011
  • 资助金额:
    $ 75.9万
  • 项目类别:
Dissecting the Fabric of the Cerebral Cortex
解剖大脑皮层的结构
  • 批准号:
    8720779
  • 财政年份:
    2011
  • 资助金额:
    $ 75.9万
  • 项目类别:
Dissecting the Fabric of the Cerebral Cortex
解剖大脑皮层的结构
  • 批准号:
    8143960
  • 财政年份:
    2011
  • 资助金额:
    $ 75.9万
  • 项目类别:
Mechanisms of Perceptual Learning in Primary Visual Cortex
初级视觉皮层知觉学习的机制
  • 批准号:
    8139747
  • 财政年份:
    2008
  • 资助金额:
    $ 75.9万
  • 项目类别:
Mechanisms of Perceptual Learning in Primary Visual Cortex
初级视觉皮层知觉学习的机制
  • 批准号:
    7533774
  • 财政年份:
    2008
  • 资助金额:
    $ 75.9万
  • 项目类别:

相似海外基金

Practical Study on Disaster Countermeasure Architecture Model by Sustainable Design in Asian Flood Area
亚洲洪泛区可持续设计防灾建筑模型实践研究
  • 批准号:
    17K00727
  • 财政年份:
    2017
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Functional architecture of a face processing area in the common marmoset
普通狨猴面部处理区域的功能架构
  • 批准号:
    9764503
  • 财政年份:
    2016
  • 资助金额:
    $ 75.9万
  • 项目类别:
Heating and airconditioning by hypocausts in residential and representative architecture in Rome and Latium studies of a phenomenon of luxury in a favoured climatic area of the Roman Empire on the basis of selected examples.
罗马和拉齐奥的住宅和代表性建筑中的火烧供暖和空调根据选定的例子,研究了罗马帝国有利的气候地区的奢华现象。
  • 批准号:
    317469425
  • 财政年份:
    2016
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Research Grants
SBIR Phase II: Area and Energy Efficient Error Floor Free Low-Density Parity-Check Codes Decoder Architecture for Flash Based Storage
SBIR 第二阶段:用于基于闪存的存储的面积和能源效率高、无错误层的低密度奇偶校验码解码器架构
  • 批准号:
    1632562
  • 财政年份:
    2016
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Standard Grant
SBIR Phase I: Area and Energy Efficient Error Floor Free Low-Density Parity-Check Codes Decoder Architecture for Flash Based Storage
SBIR 第一阶段:用于基于闪存的存储的面积和能源效率高、无错误层低密度奇偶校验码解码器架构
  • 批准号:
    1520137
  • 财政年份:
    2015
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Standard Grant
A Study on The Spatial Setting and The Inhavitant's of The Flood Prevention Architecture in The Flood Area
洪泛区防洪建筑空间设置及居民生活研究
  • 批准号:
    26420620
  • 财政年份:
    2014
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
  • 批准号:
    327691-2007
  • 财政年份:
    2011
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Discovery Grants Program - Individual
A FUNDAMENTAL STUDY ON UTILIZATION OF THE POST-WAR ARCHITECTURE AS URBAN REGENERATION METHOD, A case of the central area of Osaka city
战后建筑作为城市更新方法的基础研究——以大阪市中心区为例
  • 批准号:
    22760469
  • 财政年份:
    2010
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
  • 批准号:
    327691-2007
  • 财政年份:
    2010
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Discovery Grants Program - Individual
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
  • 批准号:
    327691-2007
  • 财政年份:
    2009
  • 资助金额:
    $ 75.9万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了