Experimental Irradiation

实验辐照

• 批准号: 8300295
• 负责人: MAX S. WICHA
• 金额: $ 24.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300295
• 关键词: Animals; Area; Basic Science; Breast; Cancer Center; Cancer Center Support Grant; Canis familiaris; Cell Culture Techniques; Cells; Cellular biology; Chronic; Consult; Consultations; DNA; DNA Damage; DNA Repair; Devices; Dose-Rate; Exposure to; Fostering; Goals; Hour; House mice; Immunodeficient Mouse; Incubators; Maintenance; Medical; Mus; Oryctolagus cuniculus; Quarantine; Radiation; Radiation Oncology; Radiation therapy; Radiobiology; Rattus; Research; Research Personnel; Resources; Roentgen Rays; Sampling; Science; Services; Signal Transduction; Specific Pathogen Frees; Technology; Therapeutic; Training; Translations; Treatment Protocols; Ultraviolet Rays; University of Michigan Comprehensive Cancer Center; animal facility; cancer cell; clinical application; design; dosage; experience; gastrointestinal; germ free condition; interest; investigator training; irradiation; member; oncology; programs; research study; response; tool

The Experimental Irradiation core provides for the use of radiation by the members of the University of Michigan Comprehensive Cancer Center (UMCCC). The services of this core are critical to a variety of users in the UMCCC such as those Interested in radiation biology and radiation therapy, and those for whom radiation serves a research tool. Thus, it serves the goal of the Cancer Center to encourage basic research as well as translation and clinical applications. The irradiation core maintains and operates the irradiators and also consults with each investigator before initiation of a project, The experience and expertise of the director and manager allow them to offer Investigators Information on dosage and treatment regimens, particularly In animal studies, so that experimental resources are used In an optimal way. Another goal of the core is to foster Interactions between the users of the core by connecting investigators who have used radiation In various types of experiments over the last several years. Use of the Experimental Irradiation core by a variety of members of the Cancer Center is exemplified by the distribution of users. The 53 Cancer Center members who utilize the core participate In 10 Programs Including Breast Oncology, Cancer Cell Biology, Experimental Therapeutics, Gastrointestinal Oncology, and Radiation Sciences, among others. In order to provide this vital service, the core maintains 4 Irradiation devices. The 2 orthovoltage units (In the Medical Science I and Biomedical Science buildings) are used for irradiations of cell cultures and animals (primarily mice and rats but also available for use with rabbits and dogs). The core also maintains a small animal irradiator located In tine specific pathogen free area of the mouse housing in ULAM. The availability of this unit allows Investigators to perform Irradiations without removing immunodeficient mice from the quarantined facility. The fourth Irradiator Is for low dose rate (0.1-0.3 Gy/hour) irradiations. This irradiator, located within the Radiation Oncology department in the Medical Science I Building is built inside a humidified CO{2} Incubator, permitting studies of chronic exposure to very low radiation dose rates. The core is planning to expand Its services to also offer Cancer Center members the opportunity to Irradiate cell or DNA samples with ultraviolet light of different wavelengths.

实验辐射核心为密歇根大学综合癌症中心（UMCCC）的成员提供辐射。该中心的服务对UMCCC的各种用户至关重要，例如对放射生物学和放射治疗感兴趣的用户，以及将放射作为研究工具的用户。因此，它服务于癌症中心的目标，鼓励基础研究以及翻译和临床应用。辐照中心负责维护和操作辐照器，并在项目启动前与每位研究人员进行协商，主任的经验和专业知识 和经理允许他们向研究者提供有关剂量和治疗方案的信息，特别是在动物研究中，以便以最佳方式使用实验资源。核心的另一个目标是通过连接在过去几年中在各种类型的实验中使用辐射的研究人员来促进核心用户之间的互动。癌症中心的各种成员使用实验辐照核心的例子是用户的分布。53名癌症中心成员谁利用核心参与10个项目，包括乳腺肿瘤学，癌细胞生物学，实验治疗学，胃肠道肿瘤学和放射科学等。为了提供这一至关重要的服务，核心维护4个辐照设备。2个正电压装置（在医学科学I和生物医学科学大楼）用于细胞培养物和动物（主要是小鼠和大鼠，但也可用于兔和犬）的辐照。该核心还保持了一个小动物辐照器，位于ULAM中小鼠笼舍的无特定病原体区域。该单元的可用性允许研究者在不将免疫缺陷小鼠从隔离设施中移出的情况下进行辐照。的 第四辐照器用于低剂量率（0.1-0.3戈伊/小时）辐照。该辐照器位于医学科学I楼的放射肿瘤科，内置于加湿CO{2}培养箱中，可用于研究长期暴露于极低辐射剂量率的情况。核心计划扩大其服务，也为癌症中心成员提供用不同波长的紫外线照射细胞或DNA样本的机会。