Interactions between integrative genomic islands and plasmids; role in the spread and loss of antibiotic resistance and pathogenicity determinants

整合基因组岛和质粒之间的相互作用；

• 批准号: nhmrc : GNT1128334
• 负责人: Prof Ruth Hall
• 金额: $ 77.65万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-integrative-genomic-pathogenicity-determinants/1347684
• 关键词: Interactions; between; integrative; genomic; islands

Mobile elements that integrate into bacterial chromosomes at a specific site contribute pathogenicity and antibiotic resistance determinants to their bacterial host but only a few are able to move themselves into new hosts. Some plasmids and some elements can help certain others. In this project, genetic approaches will be used to investigate how plasmids and integrative elements help one another move into a new bacterium or compete with one another to stay in the same cell.

整合到细菌染色体特定位点的移动的元件为其细菌宿主提供致病性和抗生素抗性决定簇，但只有少数能够将自身移动到新宿主中。一些质粒和一些元件可以帮助某些其他的。在这个项目中，遗传学方法将用于研究质粒和整合元件如何相互帮助进入新的细菌或相互竞争留在同一个细胞中。