Molecular Epidemiology of Antibiotic Resistant Salmonella enterica Strains Causing Human Disease

沙门氏菌感染在报告的细菌食物中毒病例中占很大比例，其中许多感染是由于耐药菌株造成的。由抗生素耐药微生物引起的感染很难治疗，通常更严重，持续时间更长，并导致更长的住院时间。这些菌株主要从食品中获得，例如肉类、乳制品、家禽、鸡蛋和其他受污染的食品，但也可以来自其他来源。食物生产动物携带的沙门氏菌菌株是大部分食物污染的源头。追查个别抗药性菌株的来源对于根除沙门氏菌是必不可少的。由于沙门氏菌种类繁多，其中一些只与特定动物或禽鸟有关，因此需要准确识别。拟议的工作将使这一过程更加准确，通过使用分子技术明确地建立可疑的联系，并揭示更多使用现有数据和方法难以辨别的联系。这应该会减少因耐药菌株而感染的人数。

Salmonella infections are responsible for a substantial proportion of reported food poisoning cases caused by bacteria and many of these infections are due to antibiotic resistant strains. Infections caused by antibiotic resistant organisms are hard to treat and generally more severe, of longer duration, and result in longer hospital stays. These strains are mostly acquired from foods, e.g. meats, dairy products, poultry, eggs, and other contaminated food products but can also be derived from other sources. Salmonella strains harboured by food-producing animals are the source of most of the food contamination.Tracing the source of individual resistant strains is essential for eradication and as there are many Salmonella types, some of which are found associated only with specific animals or birds, accurate identification is needed. The proposed work will make this process more accurate by using molecular techniques to unequivocally establish suspected connections and reveal further ones that are difficult to discern using current data and methods. This should decrease the number of infections due to resistant strains.