Interactions between integrative genomic islands and plasmids; role in the spread and loss of antibiotic resistance and pathogenicity determinants

点击翻译按钮获取中文摘要

Mobile elements that integrate into bacterial chromosomes at a specific site contribute pathogenicity and antibiotic resistance determinants to their bacterial host but only a few are able to move themselves into new hosts. Some plasmids and some elements can help certain others. In this project, genetic approaches will be used to investigate how plasmids and integrative elements help one another move into a new bacterium or compete with one another to stay in the same cell.