A new mechanism for transposition of antibiotic resistance genes

抗生素抗性基因转座的新机制

• 批准号: nhmrc : 1086267
• 负责人: Prof Ruth Hall
• 金额: $ 33.46万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-mechanism-transposition-resistance-genes/519126
• 关键词: new; mechanism; transposition; antibiotic; resistance

Understanding how antibiotic resistance genes are acquired by bacteria is important if we are to understand how bacteria become resistant in so many antibiotics, limiting treatment options. This project will investigate the way a family of insertion sequences captures and then moves resistance genes. This mechanism contributes to resistance in many bacterial pathogens including ones that are resistant to many different antibiotics.

如果我们要了解细菌如何对如此多的抗生素产生耐药性，那么了解细菌如何获得抗生素耐药性基因是很重要的，从而限制了治疗选择。这个项目将研究插入序列家族捕获并移动抗性基因的方式。这种机制有助于许多细菌病原体的耐药性，包括对许多不同抗生素具有耐药性的病原体。