Alzheimers Disease Patient Registry

描述(由申请人提供)：梅奥老年诊所研究(MCSA)成立于2004年，是一项以人口为基础的研究，研究对象是明尼苏达州奥姆斯特县的老龄化、轻度认知障碍(MCI)和痴呆症。具体目的是估计正常认知、MCI及其亚型的人群患病率，估计MCI和痴呆的发病率，并开始探索这些情况的预测因素。在建议的更新期内，我们计划改善MCI和痴呆症的发病率，并评估各种传统和新因素的效用，包括医学合并症、生物标志物和成像方法，以预测MCI和痴呆症。我们提出了以下具体目标：具体目标1：获得对MCI、其亚型、痴呆及其包括阿尔茨海默病在内的亚型的正常认知发生率的稳定估计，以及从MCI到痴呆的性别和假定病因。具体目的2：研究从正常认知到MCI和痴呆的潜在危险因素或预测因素，包括临床、生化和影像标志物。具体目标3：探索由特定目标2引起的危险因素或预测因素的多变量模型，用于按性别和病因从正常认知向MCI和痴呆的转变，以及按亚型和性别从MCI向痴呆的转变。具体目标4：为相关研究项目提供受试者和生物材料，并为培训新的研究人员提供平台。为了实现这些目标，到拟议的赠款开始时，现有的队列将补充到2000人(大约1650人认知正常，350人认知正常)。我们将使用梅奥诊所的医疗记录链接系统来验证医疗合并症，并评估它们作为我们研究结果的预测因素的作用。在拟议的赠款续期开始时，我们将完成对参与者的1500多次定量MRI扫描，并将对从队列中随机选择的600人进行脑脊液和匹兹堡化合物B扫描。这些指标将与年度血浆A(3项指标)和基因信息相结合，开发多变量预测模型。这项拟议的研究将是首次尝试将临床、神经影像和生物标记物信息结合起来，在5-10年的时间内预测大型非痴呆人群队列中的认知障碍。相关性(参见说明)：我们迫切需要技术来预测哪些人将来会发展为轻度认知障碍和阿尔茨海默病(AD)。梅奥老年临床研究旨在探索常见和新的医疗风险因素、神经成像测量和生物标记物在以人群为基础的环境中预测AD的有效性。这些信息对于公共卫生目的和规划预防阿尔茨海默病的临床试验至关重要。

DESCRIPTION (provided by applicant): The Mayo Clinic Study of Aging (MCSA) was established in 2004 as a population-based study of aging, mild cognitive impairment (MCI) and dementia in Olmsted County, MN. The specific aims were designed to estimate the population prevalence of normal cognition, MCI and its subtypes, to estimate incidence rates of MCI and dementia, and begin to explore predictors for these conditions. In the proposed renewal period, we plan to refine the incidence rates for MCI and dementia and to evaluate the utility of a variety of traditional and novel factors including medical comorbidities, biomarkers and imaging measures for predicting MCI and dementia. We propose the following specific aims: Specific Aim 1: To obtain stable estimates of incidence rates for normal cognition to MCI, its subtypes, and dementia, and its subtypes including Alzheimer's disease, and from MCI to dementia by sex and presumed etiology. Specific Aim 2: To investigate potential risk factors or predictors including clinical, biochemical and imaging markers for transitions from normal cognition to MCI and to dementia by sex and etiology, and from MCI to dementia by sex and etiology. Specific Aim 3: To explore multivariable models of risk factors or predictors resulting from Specific Aim 2 for transitions from normal cognition to MCI and dementia by sex and etiology and for MCI to dementia by subtypes and sex. Specific Aim 4: To provide subjects and biological materials for related research projects and provide a platform for training new investigators. To accomplish these goals, the current cohort will be replenished to 2000 persons (approximately 1650 cognitively normal and 350 MCI) by the time of the proposed grant initiation. We will use the Mayo Clinic medical records-linkage system to validate medical comorbidities and evaluate their role as predictors for our study outcomes. At the initiation of the proposed grant renewal period, we will have completed over 1500 quantitative MRI scans on the participants and will be in the process of obtaining cerebrospinal fluid and Pittsburgh Compound B scans on 600 persons randomly selected from the cohort. These measures will be combined with annual plasma A (3 measures and genotype information to develop multivariable prediction models. This proposed study will represent one of the first attempts to combine clinical, neuroimaging and biomarker information as predictors of cognitive impairment in a large non-demented population-based cohort over a period of 5 - 10 years. RELEVANCE (See instructions): We urgently need techniques to predict which individuals will develop mild cognitive impairment and Alzheimer's disease (AD) in the future. The Mayo Clinic Study of Aging is designed to explore the utility of common and novel medical risk factors, neuroimaging measures and biomarkers to predict AD in a population-based setting. This information is essential for public health purposes and for the planning of clinical trials for the prevention of AD.