Training Program in Investigative Gastroenterology

描述（由申请人提供）：本延续胃肠病学研究培训计划提案的目标是准备医学博士，哲学博士、或医学博士/博士博士后研究员作为学术胃肠病学的独立调查员。多元化，经验丰富的教师将提供机会，学习细胞和分子生物学或临床研究的当代方法，在五个广泛的领域之一：A）损伤，纤维化信号转导和基因调控; B）癌症生物学和遗传学; C）免疫学和病毒学; D）代谢，发育和干细胞的分子基础;或E）肝胆和胃肠道疾病的患者导向临床研究。培训将提供一个 为今后在胃肠病学研究中取得成功奠定坚实基础。为此，从胃肠病学，肝病，肾病，血液学/肿瘤学，传染病，临床免疫学和内分泌学以及其他两个部门和六个研究所和中心招募了专家教师。学员将从四个来源之一进入该计划：1）在西奈山医学院完成至少18个月的临床胃肠病学研究金后; 2）在西奈山医学院完成临床胃肠病学研究金加一年的临床肝病学后; 3）授予博士学位后，在生命科学学位，或4）完成后，特殊候选人的医学住院医师。实习生候选人将投入至少两年的培训，无论是实验室或基于患者的研究。每年，该基金将 继续支持PGY 4 - PGY 6级别的3名受训人员。迄今为止，赠款学员的强大生产力和学术职业选择加强了这个10年之久的计划的成功。至少90%的学员时间将致力于在教师导师的指导下在实验室或临床环境中进行个性化研究项目。此外，所有学员参加每周的实验室或临床小组会议，参加相关的部门，部门和机构的研究为导向的会议，并报名参加专门设计的实验室或临床研究方法的课程。这一强调转化研究的综合提案将培养未来的胃肠病学研究学术领导者。这种培训对于促进数千万受胃肠道和肝胆疾病影响的美国人的护理至关重要，包括通过严格的培训对受影响患者进行临床管理的新方法。

DESCRIPTION (provided by applicant): The goal of this continuation Gastroenterology Research Training Program proposal is to prepare M.D., Ph.D., or M.D./Ph.D. postdoctoral fellows for careers as independent investigators in academic Gastroenterology. A diverse, experienced faculty will provide the opportunity to learn contemporary methods of cellular and molecular biology or clinical research by mentorship in one of five broad areas: A) Injury, Fibrosis Signaling & Gene Regulation; B) Cancer Biology & Genetics; C) Immunology and Virology; D) Molecular Basis of Metabolism, Development & Stem cells; or E) Patient-oriented Clinical Investigation in Hepatobililary and Gastrointestinal Diseases. The training will provide a solid foundation for future success in investigative Gastroenterology. To do so, expert faculty have been recruited from the Divisions of Gastroenterology, Liver Diseases, Nephrology, Hematology/Oncology, Infectious Diseases, Clinical Immunology and Endocrinology, and from two other Departments and six Research Institutes and Centers. Trainees will enter the program from one of four sources: 1) Following completion of least 18 months of clinical Gastroenterology fellowship at the Mount Sinai School of Medicine; 2) Following completion of a clinical Gastroenterology fellowship plus a year of clinical Hepatology at the Mount Sinai School of Medicine; 3) After the awarding of a Ph.D. degree in life sciences, or 4) Following completion of a Medicine Residency for exceptional candidates. Trainee candidates will devote a minimum of two years to training in either laboratory- or patient-based research. Each year this grant will continue support 3 trainees at the PGY 4 - PGY 6 level. The strong productivity and academic career choices of the grant's trainees to date reinforce the success of this 10 yr-old program. At least 90% of trainees' time will be devoted to working in the laboratory or clinical setting on an individualized research project under the guidance of faculty mentor(s). In addition, all trainees participate in weekly laboratory or clinical group meetings, attend relevant divisional, departmental and institutional research-oriented conferences, and enroll in specifically designed coursework in laboratory or clinical investigative methods. This integrated proposal emphasizing translational research will train future academic leaders in investigative gastroenterology. Such training will be essential to enable advances in the care of tens of million Americans affected by gastrointestinal and hepatobiliary diseases, including new approaches to the clinical management of affected patients through rigorous training.