Community Clinical Oncology Program: FL Pediatric CCOP

社区临床肿瘤学计划：FL 儿科 CCOP

• 批准号: 8850953
• 负责人: JAMES L TALBERT
• 金额: $ 4.69万
• 依托单位: FLORIDA ASSN OF PEDIATRIC TUMOR PROG
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-24 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8850953
• 关键词: African American; Cancer Center; Cancer Control; Cancer Control Research; Caring; Child; Childhood; Children' s Oncology Group; Clinic; Clinical Trials; Communities; Community Clinical Oncology Program; Community Hospitals; Controlled Study; Country; County; Development; Diagnosis; Discipline; Disease; Doctor of Medicine; Enrollment; Ensure; Florida; Funding; Goals; Grant; Guidelines; Health Personnel; Health system; Heart; Hispanics; Home environment; Hospitals; Institution; Intervention; Investigational Drugs; Island; Latino; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Minority; Operative Surgical Procedures; Pathology; Patients; Patterns of Care; Pediatric Hospitals; Pediatric Neoplasm; Pediatric Oncology; Performance; Population; Procedures; Protocols documentation; Puerto Rico; Quality Control; Quality of Care; Radiation therapy; Research; Risk Factors; Science; Services; Site; Treatment Protocols; U-Series Cooperative Agreements; West Indies; base; cancer care; cancer prevention; chemotherapy; community setting; drug quality; member; population based; programs; quality assurance

DESCRIPTION (provided by applicant): The Florida Pediatric Community Clinical Oncology Program is a consortium of six Florida hospitals and one hospital in Puerto Rico. It is the longest functioning exclusively pediatric CCOP in the US. The CCOP has been continuously funded since 1983 and has the Children's Oncology Group (COG) and the H. Lee Moffitt Cancer Center CCOP Research Base as its research bases. It is among the single largest contributor of patients to treatment and cancer control studies in COG over this 26 year period. The CCOP consistently has outstanding compliance scores and contributes to the administration and science of COG through its members who chair or co-chair research base protocols. The CCOP geographically covers the entire state of Florida and provides pediatric oncology care to the largest population centers in Florida, the fourth largest state in the country: Orlando, Tampa, Ft. Myers, and Hollywood Florida. The CCOP hospital in Puerto Rico services the entire island and the neighboring Caribbean islands and is the major contributor of minority patients to studies. The goal of the Florida Pediatric CCOP is to make available the latest advances in cancer care to patients in Florida and Puerto Rico through participation in clinical trials and to register the majority of their eligible patients on COG protocols, thereby providing quality care in patients' home communities. The Moffitt CCOP Research Base enhances the availability of cancer prevention and control studies. The CCOP provides a unique opportunity to study a geographically-defined population to investigate risk factors, patterns of care, and population-based interventions. The Florida Pediatric CCOP also maintains the CCOP Patient Log which affords the opportunity to ensure the majority of eligible patients are registered on appropriate COG protocols. Over 194 patient registrations are anticipated per year on COG treatment protocols and 38 on protocols approved for cancer control credits per year through the 7 Florida Pediatric CCOP participating centers. COG and Moffitt quality- control procedures apply uniformly to the Florida Pediatric CCOP, ensuring compliance with protocols and external review of pathology, radiotherapy, surgery, and chemotherapy. RELEVANCE: The CCOP is the only mechanism for the majority of childhood cancer health care providers and cases in Florida and Puerto Rico to access cooperative group treatment and cancer control studies. It provides access to protocols, investigational drugs, quality assurance review and an opportunity to participate in cutting edge research that is not available otherwise in a community setting.

描述（由申请人提供）：佛罗里达儿科社区临床肿瘤学项目是由佛罗里达的六家医院和波多黎各的一家医院组成的联盟。它是美国运行时间最长的儿科专用CCOP。CCOP自1983年以来一直得到资助，并设有儿童肿瘤学小组（COG）和H。李莫菲特癌症中心CCOP研究基地作为其研究基地。在这26年期间，它是COG治疗和癌症控制研究中患者的单一最大贡献者之一。CCOP一贯具有出色的合规分数，并通过其主持或共同主持研究基础协议的成员为COG的管理和科学做出贡献。CCOP在地理上覆盖整个佛罗里达州，并为全国第四大州佛罗里达最大的人口中心提供儿科肿瘤护理：奥兰多，坦帕，佛罗里达州。迈尔斯和好莱坞佛罗里达。波多黎各的CCOP医院为整个岛屿和邻近的加勒比岛屿提供服务，是少数民族患者研究的主要贡献者。佛罗里达儿科CCOP的目标是通过参与临床试验向佛罗里达和波多黎各的患者提供癌症护理的最新进展，并根据COG协议登记大多数符合条件的患者，从而在患者的家庭社区提供优质护理。莫菲特CCOP研究基地提高了癌症预防和控制研究的可用性。CCOP提供了一个独特的机会来研究地理上定义的人群，以调查风险因素，护理模式和基于人群的干预措施。佛罗里达儿科CCOP还维护CCOP患者日志，以确保大多数合格患者按照适当的COG方案登记。通过7个佛罗里达儿科CCOP参与中心，预计每年有超过194名患者登记接受COG治疗方案，38名患者登记接受批准的癌症控制积分方案。COG和Moffitt质量控制程序统一适用于佛罗里达儿科CCOP，确保符合方案和病理学、放疗、手术和化疗的外部审查。 相关性：CCOP是佛罗里达和波多黎各大多数儿童癌症保健提供者和病例获得合作小组治疗和癌症控制研究的唯一机制。它提供了访问协议，研究药物，质量保证审查和机会，参与尖端研究，否则在社区环境中不可用。

项目成果

Treatment outcome in children with malignancies associated with human immunodeficiency virus infection.

人类免疫缺陷病毒感染相关恶性肿瘤儿童的治疗结果。

• DOI: 10.1016/s0022-3476(05)82660-5
• 发表时间: 1990
• 期刊: The Journal of pediatrics
• 作者: Montalvo,FW;Casanova,R;Clavell,LA
• 通讯作者: Clavell,LA

The Ninth Annual American Association of cancer research international conference on frontiers in cancer prevention research.

第九届美国癌症研究协会年度癌症预防研究前沿国际会议。

• DOI: 10.1158/1940-6207.capr-11-0018
• 发表时间: 2011
• 期刊: Cancer prevention research (Philadelphia, Pa.)
• 作者: Xu,Li;Wang,SophiaS;Healey,MeganA;Faupel-Badger,JessicaM;Wilken,JasonA;Battaglia,Tracy;Szabo,Eva;Mao,JennyT;Bergan,RaymondC
• 通讯作者: Bergan,RaymondC

A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia.

• DOI: 10.1016/j.oraloncology.2013.05.011
• 发表时间: 2013-09
• 期刊: ORAL ONCOLOGY
• 影响因子: 4.8
• 作者: Wong, Stuart J.;Campbell, Bruce;Massey, Becky;Lynch, Denis P.;Cohen, Ezra E. W.;Blair, Elizabeth;Selle, Rebecca;Shklovskaya, Julia;Jovanovic, Borko D.;Skripkauskas, Silvia;Dew, Alexander;Kulesza, Peter;Parimi, Vamsi;Bergan, Raymond C.;Szabo, Eva
• 通讯作者: Szabo, Eva

A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast.

• DOI: 10.1158/1078-0432.ccr-13-3045
• 发表时间: 2014-07-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Lee O;Page K;Ivancic D;Helenowski I;Parini V;Sullivan ME;Margenthaler JA;Chatterton RT Jr;Jovanovic B;Dunn BK;Heckman-Stoddard BM;Foster K;Muzzio M;Shklovskaya J;Skripkauskas S;Kulesza P;Green D;Hansen NM;Bethke KP;Jeruss JS;Bergan R;Khan SA
• 通讯作者: Khan SA

Inhibition of cancer cell invasion and metastasis by genistein.

• DOI: 10.1007/s10555-010-9238-z
• 发表时间: 2010-09
• 期刊: CANCER AND METASTASIS REVIEWS
• 影响因子: 9.2
• 作者: Pavese, Janet M.;Farmer, Rebecca L.;Bergan, Raymond C.
• 通讯作者: Bergan, Raymond C.