Training Program in Brain Tumor Biology

描述（由申请人提供）：UAB脑肿瘤生物学多学科培训计划培养基础和转化脑肿瘤生物学领域的高积极性博士生预科生和博士和医学博士毕业生。该项目建立在神经肿瘤学项目和UAB脑肿瘤孢子基金支持的跨学科基础和转化调查工作的基础上。17名教员担任该培训项目的导师。主要合作伙伴是基于主题的研究生生物医学科学计划，UAB MSTP计划和博士后教育办公室。脑肿瘤培训项目包括致力于突变疱疹病毒的溶瘤特性、单克隆抗体治疗的新临床应用、信号转导途径、系统生物学、生物信息学、基因组学、动力学、先天免疫反应、胶质瘤干细胞、侵入性和血管生成机制、生物能量学和氧化应激等领域培训的教师。一个有效的跨学科培训计划要求教师具有协作和协同的科学兴趣。在Pub-Med上对这17位导师的搜索显示，95%的人至少与一位其他导师一起发表过论文。这种承诺的培训环境为跨学科研究和培训的实施提供了理想的环境。在过去的五年里，有8名博士后和6名博士预科生得到了支持，其中14人中有13人继续从事生物医学研究、教学和/或培训。学员们出色的论文发表记录证明了这个项目的成功，他们在竞争激烈的期刊上发表了48篇同行评议的论文，另有11篇正在评审或准备中。已作出重大努力，征聘人数不足的少数民族，并加强受训者之间的性别平等。我们的学员中男性占57%(8/14)，女性占43%(6/14)，其中包括22%未被充分代表的少数民族（3/14；非洲裔美国人和西班牙裔美国人）。他们与来自7个部门的10名主要或共同导师进行了培训。由于我们的许多导师除了研究活动外还参与患者护理，因此该计划为基础和应用脑肿瘤生物学提供了强有力的接口。培训项目在教学培训和丰富机会方面提供了一个特殊的跨学科环境。教学部分包括脑肿瘤生物学高级课程，一门名为脑肿瘤临床课程的新课程，以及一门新的“动手”TCGA/生物信息学教程。丰富的活动包括新的每月脑肿瘤研究进展会议，每月脑肿瘤研究系列研讨会，以及年度UAB脑肿瘤孢子科学撤退。总的来说，研究培训，教学培训和丰富活动将确保下一代基础/转化研究人员的发展，解决与脑肿瘤相关的引人注目的问题。

DESCRIPTION (provided by applicant): The multidisciplinary UAB Training Program in Brain Tumor Biology trains highly motivated predoctoral students and Ph.D. and M.D. graduates in the fields of fundamental and translational brain tumor biology. The program builds on the interdisciplinary basic and translational investigative efforts supported by the Neuro- Oncology Program and the UAB Brain Tumor SPORE Grant. Seventeen faculty members serve as mentors on this training program. Key partners are the thematically based Graduate Biomedical Sciences Program, the UAB MSTP Program and the Office of Postdoctoral Education. The Brain Tumor Training Program incorporates faculty committed to training in the fields of oncolytic properties of mutant herpes viruses, novel clinical applications of monoclonal antibody therapy, signal transduction pathways, systems biology, bioinformatics, genomics, kinomics, innate immune response, glioma stem cells, invasive and angiogenic mechanisms, bio-energetics and oxidative stress. An effective interdisciplinary training program requires faculty with collaborative and synergistic scientific interests. A Pub-Med search of the 17 mentors revealed that 95% published with at least one other mentor. This committed training environment provides an ideal setting for the implementation of interdisciplinary research and training. Over the last five years, 8 postdoctoral and 6 predoctoral trainees have been supported, with 13 of 14 continuing in biomedical research, teaching and/or training. The success of this program is evident by the outstanding publication record of the trainees, having published 48 peer-reviewed manuscripts in highly competitive journals, with an additional 11 under review or in preparation. A major effort has been made to recruit under-represented minorities and to enhance gender equality among the trainees. Our trainees have been 57% male (8/14) and 43% female (6/14), and have included 22% under-represented minorities (3/14; African American and Hispanic American). They have trained with 10 primary or co-mentors from 7 departments. Because a large number of our mentors are involved in patient care in addition to their research activities, the program provides a strong interface between basic and applied brain tumor biology. The Training Program provides an exceptional interdisciplinary environment in terms of didactic training and enrichment opportunities. The didactic component encompasses the Advanced Course in Brain Tumor Biology, a new course entitled Brain Tumor Clinical Course, and a new "hand-on" TCGA/Bioinformatics Tutorial. Enrichment activities include a new Monthly Research-In-Progress Brain Tumor Conference, a Monthly Brain Tumor Research Seminar Series, and the Annual UAB Brain Tumor SPORE Scientific Retreat. Collectively, the research training, didactic training and enrichment activities will ensure the development of the next generation of basic/translational researchers addressing the compelling problems related to brain tumors.