Training Program in Brain Tumor Biology

描述（由申请人提供）：脑肿瘤生物学多学科UAB培训计划培养高度积极的博士前学生和博士。和医学博士。基础和转化脑肿瘤生物学领域的毕业生。该计划建立在神经肿瘤学计划和UAB脑肿瘤孢子补助金支持的跨学科基础和翻译研究工作的基础上。17名教员担任这一培训计划的导师。主要合作伙伴是基于主题的研究生生物医学科学计划，UAB MSTP计划和博士后教育办公室。脑肿瘤培训计划包括致力于突变疱疹病毒的溶瘤特性，单克隆抗体治疗的新临床应用，信号转导途径，系统生物学，生物信息学，基因组学，kinomics，先天免疫反应，胶质瘤干细胞，侵入性和血管生成机制，生物能量学和氧化应激等领域的培训教师。一个有效的跨学科培训计划需要具有协作和协同科学兴趣的教师。对17位导师的Pub-Med搜索显示，95%的人与至少一位其他导师一起发表文章。这种承诺的培训环境为跨学科研究和培训的实施提供了理想的环境。在过去五年中，有8名博士后和6名博士前学员得到了支助，其中14人中有13人继续从事生物医学研究、教学和/或培训。该计划的成功体现在学员的杰出出版记录上，他们在竞争激烈的期刊上发表了48篇同行评审的手稿，另有11篇正在审查或准备中。已作出重大努力，招聘代表性不足的少数民族，并加强受训人员中的两性平等。我们的受训人员中有57%为男性（8/14），43%为女性（6/14），其中包括22%的少数民族（3/14;非洲裔美国人和西班牙裔美国人）。他们接受了来自7个部门的10名主要或共同导师的培训。由于我们的导师中有大量的参与病人护理除了他们的研究活动，该计划提供了基础和应用脑肿瘤生物学之间的强有力的接口。该培训计划提供了一个特殊的跨学科的教学培训和丰富的机会方面的环境。教学部分包括脑肿瘤生物学高级课程，一个新的课程，题为脑肿瘤临床课程，和一个新的“动手”TCGA/生物信息学课程。丰富的活动包括一个新的每月研究进展脑肿瘤会议，每月脑肿瘤研究研讨会系列，和年度UAB脑肿瘤孢子科学务虚会。总的来说，研究培训，教学培训和丰富活动将确保下一代基础/翻译研究人员的发展，解决与脑肿瘤有关的紧迫问题。

DESCRIPTION (provided by applicant): The multidisciplinary UAB Training Program in Brain Tumor Biology trains highly motivated predoctoral students and Ph.D. and M.D. graduates in the fields of fundamental and translational brain tumor biology. The program builds on the interdisciplinary basic and translational investigative efforts supported by the Neuro- Oncology Program and the UAB Brain Tumor SPORE Grant. Seventeen faculty members serve as mentors on this training program. Key partners are the thematically based Graduate Biomedical Sciences Program, the UAB MSTP Program and the Office of Postdoctoral Education. The Brain Tumor Training Program incorporates faculty committed to training in the fields of oncolytic properties of mutant herpes viruses, novel clinical applications of monoclonal antibody therapy, signal transduction pathways, systems biology, bioinformatics, genomics, kinomics, innate immune response, glioma stem cells, invasive and angiogenic mechanisms, bio-energetics and oxidative stress. An effective interdisciplinary training program requires faculty with collaborative and synergistic scientific interests. A Pub-Med search of the 17 mentors revealed that 95% published with at least one other mentor. This committed training environment provides an ideal setting for the implementation of interdisciplinary research and training. Over the last five years, 8 postdoctoral and 6 predoctoral trainees have been supported, with 13 of 14 continuing in biomedical research, teaching and/or training. The success of this program is evident by the outstanding publication record of the trainees, having published 48 peer-reviewed manuscripts in highly competitive journals, with an additional 11 under review or in preparation. A major effort has been made to recruit under-represented minorities and to enhance gender equality among the trainees. Our trainees have been 57% male (8/14) and 43% female (6/14), and have included 22% under-represented minorities (3/14; African American and Hispanic American). They have trained with 10 primary or co-mentors from 7 departments. Because a large number of our mentors are involved in patient care in addition to their research activities, the program provides a strong interface between basic and applied brain tumor biology. The Training Program provides an exceptional interdisciplinary environment in terms of didactic training and enrichment opportunities. The didactic component encompasses the Advanced Course in Brain Tumor Biology, a new course entitled Brain Tumor Clinical Course, and a new "hand-on" TCGA/Bioinformatics Tutorial. Enrichment activities include a new Monthly Research-In-Progress Brain Tumor Conference, a Monthly Brain Tumor Research Seminar Series, and the Annual UAB Brain Tumor SPORE Scientific Retreat. Collectively, the research training, didactic training and enrichment activities will ensure the development of the next generation of basic/translational researchers addressing the compelling problems related to brain tumors.