Training Program in Brain Tumor Biology

描述(由申请者提供)：本申请为UAB脑肿瘤生物学综合培训计划提供严格的跨学科教育，以培养该领域的独立研究科学家。该培训计划设在细胞生物学、病理学和外科系。培训计划的16名教职员工是根据他们在基础和转化性脑瘤研究、动态研究计划和培训记录方面的互补研究专长而挑选出来的。研究项目包括：脑肿瘤迁移/侵袭的分子方面的研究，血管生成，细胞表面受体启动的信号转导，细胞凋亡的调控，以及新的病毒治疗方法。学员将通过新的脑瘤生物学研究生水平课程、每周一次的脑瘤研究会议、每月一次的脑瘤研究和治疗系列研讨会以及每年一次的UAB脑瘤生物学科学务虚会，正式整合学员对这种疾病的全方位的智力和实验方法。 培训计划将由Etty Benveniste博士(主任)、Candess Gladson博士执行 (联席主任)和吉姆·马克特博士(联席主任)，以及一个执行委员会(贝诺斯、吉莱斯皮、罗斯和桑特海默博士)。这组教师将负责制定个人培训计划，整合研究和教学部分，监督正式要求，招聘，对正式申请进行竞争性审查，并监督受训人员的进度。这一培训计划的另一个优势是与UAB脑瘤孢子补助金(PI：Yancey Gillesbie博士)和UAB综合癌症中心神经肿瘤学计划的密切联系。高级博士后学生和博士后实习生都需要资金。因此，这个脑瘤生物学的培训计划将使未来的研究人员在这一重要的和临床相关的研究领域做好准备。

DESCRIPTION (provided by applicant): This application for a comprehensive Training Program in Brain Tumor Biology at UAB offers the rigorous interdisciplinary education required for the development of independent research scientists in this field. The Training Program is based in the Departments of Cell Biology, Pathology, and Surgery. The 16 faculty members of the Training Program have been selected based on their complementary research expertise in basic and translational brain tumor research, dynamic research programs, and training records. Research projects include: studies of the molecular aspects of brain tumor migration/invasion, angiogenesis, cell surface receptor-initiated signaling, the regulation of apoptosis, and novel viral approaches to therapy. The exposure of the trainees to the full spectrum of intellectual and experimental approaches to this disease will be integrated formally through a new graduate level course in Brain Tumor Biology, a weekly Brain Tumor Research Conference, a monthly Brain Tumor Research and Treatment Seminar Series, and an annual UAB Brain Tumor Biology Scientific Retreat. The Training Program will be administered by Dr. Etty Benveniste (Director), Dr. Candece Gladson (Co-Director), and Dr. Jim Markert (Co-Director), and by an Executive Committee (Drs. Benos, Gillespie, Roth and Sontheimer). This group of faculty will be responsible for development of individual training plans, integration of research and didactic components, oversight of formal requirements, recruitment, competitive review of formal applications, and oversight of the trainees' progress. An additional strength of this Training Program is the close association with the UAB Brain Tumor SPORE Grant (PI: Dr. Yancey Gillespie), and the UAB Comprehensive Cancer Center Neuro-Oncology Program. Funding is requested for both advanced pre-doctoral students and postdoctoral trainees. Thus, this Training Program in Brain Tumor Biology will prepare future investigators in this important and clinically relevant area of research.