Training Program in Brain Tumor Biology

脑肿瘤生物学培训计划

• 批准号: 8871806
• 负责人: Etty N Benveniste
• 金额: $ 19万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8871806
• 关键词: Brain Neoplasms; Training Programs; Tumor Biology

DESCRIPTION (provided by applicant): The multidisciplinary UAB Training Program in Brain Tumor Biology trains highly motivated predoctoral students and Ph.D. and M.D. graduates in the fields of fundamental and translational brain tumor biology. The program builds on the interdisciplinary basic and translational investigative efforts supported by the Neuro- Oncology Program and the UAB Brain Tumor SPORE Grant. Seventeen faculty members serve as mentors on this training program. Key partners are the thematically based Graduate Biomedical Sciences Program, the UAB MSTP Program and the Office of Postdoctoral Education. The Brain Tumor Training Program incorporates faculty committed to training in the fields of oncolytic properties of mutant herpes viruses, novel clinical applications of monoclonal antibody therapy, signal transduction pathways, systems biology, bioinformatics, genomics, kinomics, innate immune response, glioma stem cells, invasive and angiogenic mechanisms, bio-energetics and oxidative stress. An effective interdisciplinary training program requires faculty with collaborative and synergistic scientific interests. A Pub-Med search of the 17 mentors revealed that 95% published with at least one other mentor. This committed training environment provides an ideal setting for the implementation of interdisciplinary research and training. Over the last five years, 8 postdoctoral and 6 predoctoral trainees have been supported, with 13 of 14 continuing in biomedical research, teaching and/or training. The success of this program is evident by the outstanding publication record of the trainees, having published 48 peer-reviewed manuscripts in highly competitive journals, with an additional 11 under review or in preparation. A major effort has been made to recruit under-represented minorities and to enhance gender equality among the trainees. Our trainees have been 57% male (8/14) and 43% female (6/14), and have included 22% under-represented minorities (3/14; African American and Hispanic American). They have trained with 10 primary or co-mentors from 7 departments. Because a large number of our mentors are involved in patient care in addition to their research activities, the program provides a strong interface between basic and applied brain tumor biology. The Training Program provides an exceptional interdisciplinary environment in terms of didactic training and enrichment opportunities. The didactic component encompasses the Advanced Course in Brain Tumor Biology, a new course entitled Brain Tumor Clinical Course, and a new "hand-on" TCGA/Bioinformatics Tutorial. Enrichment activities include a new Monthly Research-In-Progress Brain Tumor Conference, a Monthly Brain Tumor Research Seminar Series, and the Annual UAB Brain Tumor SPORE Scientific Retreat. Collectively, the research training, didactic training and enrichment activities will ensure the development of the next generation of basic/translational researchers addressing the compelling problems related to brain tumors.

描述(由申请者提供)：脑瘤生物学的多学科UAB培训计划培养积极进取的博士前学生以及基础和翻译脑瘤生物学领域的博士和医学毕业生。该计划建立在神经肿瘤学计划和UAB脑瘤孢子赠款支持的跨学科基础和转化性研究努力的基础上。17名教职员工担任这一培训计划的导师。主要合作伙伴是以主题为基础的研究生生物医学科学计划、UAB MSTP计划和博士后教育办公室。脑瘤培训计划包括致力于培训以下领域的教师：突变疱疹病毒的溶瘤特性、单抗治疗的新临床应用、信号转导途径、系统生物学、生物信息学、基因组学、运动学、先天免疫反应、胶质瘤干细胞、侵袭和血管生成机制、生物能量学和氧化应激。有效的跨学科培训计划要求教师具有协作和协同的科学兴趣。Pub-Med对这17位导师的搜索显示，95%的人至少有过一位其他导师。这种承诺的培训环境为实施跨学科研究和培训提供了理想的环境。在过去五年中，8名博士后学员和6名博士后学员得到了支持，14名学员中有13名继续从事生物医学研究、教学和/或培训。学员们出色的发表记录证明了这一计划的成功，他们在竞争激烈的期刊上发表了48篇同行评议的手稿，另有11篇正在审查或准备中。已经作出重大努力，招募任职人数不足的少数群体，并加强受训人员中的两性平等。我们的受训人员是57%的男性(8/14)和43%的女性(6/14)，并包括22%的代表性不足的少数族裔(3/14；非裔美国人和西班牙裔美国人)。他们与来自7个部门的10名主要或合作导师一起进行了培训。由于我们的大量导师除了他们的研究活动外，还参与了患者护理，该项目在基础脑瘤生物学和应用脑瘤生物学之间提供了一个强大的接口。该培训计划在教学培训和充实机会方面提供了一个特殊的跨学科环境。教学部分包括脑瘤生物学高级课程，一门名为脑瘤临床课程的新课程，以及一门新的TCGA/生物信息学教程。丰富的活动包括每月一次的新的正在进行的脑瘤研究会议，每月一次的脑瘤研究系列研讨会，以及一年一度的UAB脑瘤孢子科学务虚会。总的来说，研究培训、教学培训和充实活动将确保下一代基础/翻译研究人员的发展，解决与脑瘤有关的紧迫问题。