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Risk Factors for Second Primary Breast Cancer Among DCIS Survivors

DCIS 幸存者中第二原发乳腺癌的危险因素

基本信息

批准号：
8597519
负责人：
Christopher I Li
金额：
$ 55.46万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-06-06 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597519
关键词：
Address Adjuvant Adjuvant Therapy Age Biopsy Breast Breast Cancer Detection Breast Cancer Risk Factor Breast-Conserving Surgery Cancer Survivor Caring Categories Characteristics Clinical Comedo Contralateral Control Groups Data Decision Making Diagnosis Disease Duct (organ) structure ERBB2 gene Epidemiological Factors Epidemiology Estrogen Receptors Exogenous Hormone Therapy Family history of Funding General Population Goals In Situ In Situ Lesion Incidence Invaded Ipsilateral Lesion Literature Local Therapy Mammary gland Mammographic Density Mammography Measures Nested Case-Control Study Noninfiltrating Intraductal Carcinoma Operative Surgical Procedures Patients Population Progesterone Receptors Public Health Race Radiation Radiation therapy Recording of previous events Recruitment Activity Reporting Research Infrastructure Risk Risk Factors Sample Size Second Primary Cancers Simple mastectomy Survival Rate Survivors Time Tissues Translating Tumor Markers United States Woman Work breast cancer diagnosis breast lumpectomy burden of illness cancer cell density follow-up high risk hormone therapy malignant breast neoplasm reproductive screening sound trend tumor

项目摘要

ABSTRACT: The proposed study is a competitive renewal of our currently funded project that is investigating how epidemiological factors, clinical and pathological characteristics, and tumor marker expression influence the risk of second primary invasive contralateral breast cancer among survivors of a first primary invasive breast cancer. Here we propose to expand this work by evaluating factors that are related to risk of second primary breast cancers among ductal carcinoma in situ (DCIS) survivors. Incidence rates of DCIS have increased 7.2- fold from 1980 to 2001 in the United States, largely as a result of widespread breast cancer screening. DCIS lesions are very responsive to available therapies, and five-year disease-specific survival rates are close to 100%. However, DCIS survivors have a 3.4 to 8.6-fold higher risk of developing a second breast cancer compared to the risk that women in the general population have of developing a first breast cancer. The recent rapid rise in DCIS incidence rates has translated into a large and growing population of DCIS survivors who are particularly susceptible to developing a second breast cancer. Not all DCIS patients will go on to develop a second breast cancer, so certain surgical and adjuvant therapy combinations for DCIS constitute over- treatment for those at low risk of a second breast cancer, while others constitute under-treatment for those at high risk. At present, however, there is a lack of meaningful prognosticators to indicate which DCIS survivors are at high or low risk of developing a second breast cancer. Such prognosticators could be important guides to help these patients and their clinicians choose the most appropriate course of therapy and subsequent follow-up care. We propose to investigate how epidemiological, clinical, and histopathological characteristics of DCIS impact the risk of second primary breast cancers among DCIS survivors. We will recruit 515 patients diagnosed with DCIS and a verified subsequent second primary in situ or invasive breast cancer, and a control group consisting of 1,030 patients diagnosed only with DCIS to address the following specific aims: 1) How do epidemiological risk factors for breast cancer, including reproductive characteristics, anthropometric measures, use of exogenous hormones, mammographic density, and family history of breast cancer, influence the risks of second primary breast cancer overall, contralateral second primary breast cancer, and ipsilateral second primary breast cancer among DCIS survivors?; and 2) How do the clinical and histopathological features of DCIS, including treatments, tumor grade, and histological subtype impact risks of second primary breast cancer overall, contralateral second primary breast cancer, and ipsilateral second primary breast cancer among DCIS survivors? The proposed study will provide important information to the rapidly growing population of DCIS survivors as its results may help modulate their risk of developing a second primary breast cancer and inform their decision-making regarding DCIS treatments and subsequent breast cancer screening.

文摘:

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Association between antidepressant use and second breast cancer event after ductal carcinoma in situ diagnosis: a nested case-control study.

抗抑郁药物的使用与导管原位癌诊断后第二次乳腺癌事件之间的关联：一项巢式病例对照研究。

DOI：
10.1007/s10552-021-01551-w
发表时间：
2022
期刊：
Cancer causes & control : CCC
影响因子：
0
作者：
Mansi,ElizabethT;Malone,KathleenE;Tang,Mei-Tzu;Loroña,NicoleC;Li,ChristopherI
通讯作者：
Li,ChristopherI

Bisphosphonate Use and Breast Cancer Risk among Women with Ductal Carcinoma In Situ.

DOI：
10.1158/0008-5472.can-20-4100
发表时间：
2021-05-15
期刊：
Cancer research
影响因子：
11.2
作者：
Li CI;Flanagan MR;Tang MC;Porter PL;Malone KE
通讯作者：
Malone KE

Use of Antihypertensive Medications Not Associated with Risk of Contralateral Breast Cancer among Women Diagnosed with Estrogen Receptor-Positive Invasive Breast Cancer.

DOI：
10.1158/1055-9965.epi-15-0547
发表时间：
2015-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
0
作者：
Chen L;Malone KE;Li CI
通讯作者：
Li CI

Reproductive and menopausal factors and risk of second primary breast cancer after in situ breast carcinoma.

生殖和绝经因素以及继原位乳腺癌之后第二原发性乳腺癌的风险。

DOI：
10.1007/s10552-018-1119-8
发表时间：
2019
期刊：
Cancer causes & control : CCC
影响因子：
0
作者：
Baglia,MichelleL;Tang,Mei-TzuC;Malone,KathleenE;Porter,Peggy;Li,ChristopherI
通讯作者：
Li,ChristopherI