sodium tungstate dihydrate (STD) in Laboratory Animals for the National Toxicolog

国家毒理学实验室动物实验中的二水合钨酸钠 (STD)

• 批准号: 8845131
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 119.5万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845131
• 关键词: Animals; Antidiabetic Drugs; Caliber; Chemicals; Chronic; Clinical; Goals; Human; Laboratory Animals; Lead; Life; Metals; Military Personnel; Mus; Phase; Production; Rattus; Toxic effect; Toxicity Tests; Tungsten; Uranium; carcinogenicity; commercial application; dietary supplements; drinking water; hazard; sodium tungstate(VI)

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of sodium tungstate dihydrate (STD) in rats and mice exposed via exposure in drinking water. Tungsten is a high production volume metal that is used in a variety of commercial applications, including military applications as a replacement for lead in small caliber ammunition and as a substitute for depleted uranium in armor penetrators. In addition, tungsten is found in dietary supplements and has potential clinical use as an antidiabetic therapy. 2-Year chronic toxicity and carcinogenicity studies of STD are in the in life phase. Keywords: toxicity, carcinogenicity, drinking water, sodium tungstate dehydrate

本项目的目的是评价二水合钨酸钠（STD）通过饮用水暴露于大鼠和小鼠体内的慢性毒性和致癌性。钨是一种高产量的金属，用于各种商业应用，包括军事应用，作为小口径弹药中铅的替代品，以及作为装甲穿甲弹中贫铀的替代品。此外，钨还存在于膳食补充剂中，并具有潜在的临床用途，可用作抗糖尿病治疗。2-性病的慢性毒性和致癌性研究处于活体阶段。 关键词：毒性、致癌性、饮用水、二水钨酸钠