An Affective Intervention to Reverse the Biological Residue of Low Childhood SES

扭转儿童社会经济地位低下生物残留的情感干预

• 批准号: 8929132
• 负责人: BARBARA LEE FREDRICKSON
• 金额: $ 11.59万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8929132
• 关键词: Accounting; Adult; Affect; Affective; Aging; American; Arthritis; Attention; Behavioral; Biological; C-reactive protein; Cardiac; Cardiovascular Diseases; Childhood; Chronic; Chronic Disease; Chronic stress; Communicable Diseases; Disadvantaged; Educational process of instructing; Effectiveness; Elderly; Emotional; Environment; Evidence based intervention; Experimental Designs; Future; Gene Expression; Genes; Goals; Health; Household; Immune system; Impulsivity; Individual; Inflammation; Inflammatory; Intervention; Learning; Length; Leukocytes; Life; Life Style; Love; Malignant Neoplasms; Mediator of activation protein; Meditation; Mental Depression; Mental Health; Metabolic; Molecular Profiling; Outcome; Participant; Pathway interactions; Placebo Control; Population; Positioning Attribute; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Risk; Risk Factors; Sampling; Socioeconomic Status; Testing; Time; Up-Regulation; Ursidae Family; Viral Antibodies; Work; base; biobehavior; blind; burden of illness; cardiovascular disorder risk; design; discounting; experience; gene repression; immune activation; improved; inclusion criteria; indexing; innovation; low socioeconomic status; meetings; middle age; mindfulness meditation; mortality; novel; physical conditioning; positive emotional state; psychologic; skills; socioeconomics; telomere; theories

 DESCRIPTION (provided by applicant): Individuals raised in low socioeconomic (SES) households have been found to bear 20%-40% increased risk of costly chronic and infectious diseases and all-cause mortality, even after accounting for adulthood SES. Illuminating the biological mechanisms of these health risks, recent research has determined that severe and chronic stress endured early in life can embed a decades-long "biological residue" within the immune system, as reflected in leukocyte basal gene expression profiles, leukocyte telomere length, and levels of chronic inflammation indexed by C-reactive protein. These biological risk factors are further exacerbated by behavioral proclivities, namely, impulsivity (indexed by delay discounting) and mistrust, which are also more probable among those reared in low SES households. The overarching goal of the proposed research is to investigate whether and how this identified biological residue can be reversed in midlife. An innovative upward spiral theory o lifestyle change positions warm and empathic emotional states as key pathways to unlocking the body's inherent plasticity to reverse entrenched biological risk factors. The PI's team has identified an affective intervention - the ancient practice of loving-kindness meditation (LKM) - that produces salubrious biological effects in healthy midlife adults. The innovation of the present study lies in testing this affective intervention in a sample of midlife adults on poor health trajectories by virtue of having low childhood SES plus present-day pathogenic behavioral tendencies (i.e., impulsivity and mistrust). A dual-blind placebo-controlled randomized controlled trial (RCT) is designed to provide proof of principle that early-established biological risks factors are mutable, not permanent. It targets three Specific Aims: (1) To test whether LKM, through its effects on positive emotions, can reverse the biological residue of low childhood SES as reflected in (a) leukocyte basal gene expression (up-regulation of pro-inflammatory genes and down-regulation of antiviral and antibody genes), (b) leukocyte telomere length, and (c) C-reactive protein; (2) to identify plausible behavioral and biological moderators of the hypothesized benefits of LKM in this at-risk sample, with candidate moderators being (a) time spent meditating and (b) metabolic profile; and (3) to identify plausible biological, behavioral, and psychological mediators of the hypothesized biological benefits of LKM-induced positive emotions in this at-risk sample, with candidate mediators being improvements in (a) cardiac vagal tone, (b) delay discounting, and (c) mistrust. This research stands to identify evidence-based interventions to drastically reduce the disease burden that disproportionately affects Americans raised in low SES households.



项目成果

Attachment insecurity moderates emotion responses to mindfulness and loving-kindness meditation in adults raised in low socioeconomic status households.

• DOI: 10.1037/emo0001049
• 发表时间: 2022-09
• 期刊: EMOTION
• 影响因子: 4.2
• 作者: West, Taylor N;Don, Brian P;Fredrickson, Barbara L
• 通讯作者: Fredrickson, Barbara L

Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households.

• DOI: 10.1007/s12671-022-01857-z
• 发表时间: 2022-05
• 期刊: MINDFULNESS
• 影响因子: 3.6
• 作者: West, Taylor N;Zhou, Jieni;Brantley, Mary M;Kim, Sumi L;Brantley, Jeffrey;Salzberg, Sharon;Cole, Steve W;Fredrickson, Barbara L
• 通讯作者: Fredrickson, Barbara L