CSHL 2011 Cellular Biology of Addiction Course

描述（由申请人提供）：拟议研讨会的主要目标是提供一个基本的，国家的最先进的进展和药物成瘾的细胞和分子生物学的主要差距激烈的讨论。针对新的和有经验的研究人员，讲习班将结合联合收割机正式介绍和非正式讨论，传达的优点和兴奋的细胞和分子方法的药物成瘾研究。研讨会将强调这种方法的重要性，不仅是最昂贵的神经精神疾病，成瘾，但其适用于学习，记忆，神经化学相关的奖励，感知和神经科学的其他学科。对药物反应中发生的分子和细胞变化的研究对于澄清适应过程在成瘾的每个阶段和每种药物滥用中是否是不同的至关重要。随着基因组学和蛋白质组学的出现，现在存在一个非凡的机会来开发成瘾，渴望和复吸的神经适应过程的综合模型。讲习班将为与会者提供一系列学科，有助于开发吸毒成瘾每个阶段的综合模型。将介绍以下学科：1.成瘾概述。2.对滥用药物的神经适应。3.药物诱导的神经适应与行为表现之间的关联4。基因型/药物成瘾或药物反应的易感性。5.细胞水平的耐受性、敏感性和适应性。6.新的受体靶点。7.药物发现和开发以治疗药物滥用：细胞生物学如何做出贡献？ 本次研讨会将提供对成瘾神经适应性反应的当前和新研究的综合观点，促进关于合作和整合的讨论，并提供构建成瘾作为疾病和生物治疗新分子靶点模型所需的关键信息。在科学奋进之外，这些信息对于制定公共政策和启发公众了解药物使用和成瘾的神经生物学后果至关重要。拟议的研讨会将产生浓厚的兴趣，开放合作渠道和新的途径来调查成瘾的神经生物学。该研讨会特别努力包括不同的参与者群体，特别注意包括妇女，美国少数民族和国家和国际科学家的良好平衡。

DESCRIPTION (provided by applicant): The primary objective of the proposed workshop is to provide an intense discussion of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction. Targeted to both new and experienced investigators, the workshop will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. The workshop will stress the significance of this approach not only to the most costly neuropsychiatric disorder, addiction, but its applicability to learning, memory, neurochemical correlates of reward, perception and other disciplines of neuroscience. Research on the molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, craving, and relapse to drug use. The workshop will provide attendees with a spectrum of disciplines that can contribute to developing comprehensive models of each stage of drug addiction. The following disciplines will be presented: 1.Overview of addiction. 2. Neuroadaptation to drugs of abuse. 3. Association between drug-induced neuroadaptation and behavioral manifestations 4. Genotype/susceptibility to drug addiction or drug response. 5. Tolerance, sensitization and adaptation at the cellular level. 6. New receptor targets. 7. Drug discovery and development to treat drug abuse: how can cell biology contribute? This workshop will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration and provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, such information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The proposed workshop will generate intense interest, open conduits for collaborations and novel routes to investigating the neurobiology of addiction. The workshop makes particular efforts to include a diverse group of participants, being particularly mindful of the inclusion of women, US minorities and a good balance of national and international scientists.