Novel Therapeutic Approaches to Tuberculosis

结核病的新治疗方法

• 批准号: 8650487
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650487
• 关键词: Acute; Animal Model; Anti-Bacterial Agents; Area; Bacteria; Bacteriology; Basic Science; Biological; Cause of Death; Cellular biology; Clinical Research; Collaborations; Colorado; Communicable Diseases; Development; Disease; Ensure; Fostering; Glean; Goals; HIV; Human; Immunity; Immunology; Immunotherapy; Infection; Inflammation; Inflammatory Response; Institution; Intervention; Lung; Malaria; Malignant Neoplasms; Mycobacterium tuberculosis; Outcome; Pharmaceutical Preparations; Physiology; Population; Regimen; Research; Research Personnel; Role; Scientist; Solutions; Speed; System; Therapeutic; Tuberculosis; Vaccines; Virus Diseases; antimicrobial; base; career development; chemical genetics; chemotherapy; cytokine; design; disorder control; disorder risk; drug development; drug discovery; insight; killings; meetings; microbial; mycobacterial; next generation; novel strategies; novel therapeutic intervention; novel therapeutics; pathogen; planetary Atmosphere; public health relevance; response; success; symposium; therapeutic development; therapeutic vaccine; transmission process; tuberculosis treatment; vaccine development

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Novel Therapeutic Approaches to Tuberculosis, organized by Christopher M. Sassetti and Thomas G. Evans. The meeting will be held in Keystone, Colorado from March 30 - April 4, 2014. Despite more than a century of research, tuberculosis kills millions every year. The reasons we are unable to control this disease are well documented: the lack of an effective vaccine, inefficient chemotherapy, and an inability to predict who is at risk of disease. Traditionl approaches to antibacterial and vaccine development have produced only incremental improvements in TB therapy, and have had little effect on transmission in the developing world. This meeting will explore novel strategies to treat this disease, either through direct antimicrobil interventions or the manipulation of host immunity. Plenary sessions will explore three topical areas: 1) The mechanisms underlying the inflammatory response to M. tuberculosis, and novel strategies to ameliorate disease through the manipulation of this response; 2) New approaches to accelerate TB chemotherapy, concentrating on genetic/chemical synergies, specific targeting of persistent bacterial populations, and host-directed antimicrobial therapies; and 3) Immunotherapy for both latent and active disease, with an emphasis on cytokine modulation and therapeutic vaccines. This symposium will assemble a diverse group of scientists specializing in immunology, bacteriology, cell biology, and therapeutic development. To ensure that insights from basic science are discussed in the context of practical therapeutic solutions, attendees will be drawn from both academic and industrial institutions. A particular emphasis will be placed on lessons gleaned from other systems, such as cancer, acute inflammation, and viral infections, which could be applied to tuberculosis. This diversity of background and approach will encourage the development of truly novel approaches to treat this devastating disease.

描述(由申请人提供)：请求支持克里斯托弗·M·萨塞蒂和托马斯·G·埃文斯组织的题为结核病新治疗方法的Keystone研讨会。会议将于2014年3月30日至4月4日在科罗拉多州的Keystone举行。尽管进行了一个多世纪的研究，每年仍有数百万人死于结核病。我们无法控制这种疾病的原因是有据可查的：缺乏有效的疫苗，化疗效率低下，以及无法预测谁有患病的风险。传统的抗菌和疫苗开发方法在结核病治疗方面只产生了渐进的改进，对发展中国家的传播几乎没有影响。这次会议将探索治疗这种疾病的新策略，要么通过直接的抗微生物干预，要么通过操纵宿主免疫。全体会议将探讨三个主题领域：1)结核分枝杆菌炎症反应的潜在机制，以及通过操纵这种反应来改善疾病的新战略；2)加速结核病化疗的新方法，集中于遗传/化学协同作用、针对持久细菌种群的特定靶向和宿主导向的抗微生物疗法；以及3)潜伏期和活动期疾病的免疫治疗，重点是细胞因子调节和治疗性疫苗。这次研讨会将汇集一批专门从事免疫学、细菌学、细胞生物学和治疗开发的科学家。为了确保在实际治疗解决方案的背景下讨论来自基础科学的见解，与会者将来自学术和工业机构。将特别强调从其他系统中吸取的经验教训，如癌症、急性炎症和病毒感染，这些可能适用于结核病。这种背景和方法的多样性将鼓励开发真正新颖的方法来治疗这种毁灭性的疾病。