Impact of Maternal Caregiving on Brain-Behavior Relationships in Infants

母亲照顾对婴儿大脑行为关系的影响

• 批准号: 9150665
• 负责人: ALISON E HIPWELL
• 金额: $ 19万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9150665
• 关键词: Affect; Affective; Amygdaloid structure; Anisotropy; Area; Behavior; Biological Neural Networks; Brain; Buffers; Child; Child Rearing; Childhood; Clinical; Corpus Callosum; Corpus striatum structure; Development; Diffusion; Dimensions; Early Intervention; Emotional; Environment; Foundations; Future; Gender; Goals; Health; Hippocampus (Brain); Human; Image; Infant; Infant Behavior; Inferior; Influentials; Insula of Reil; Knowledge; Laboratories; Lateral; Life; Link; Longevity; Measures; Medial; Modality; Mothers; National Institute of Mental Health; Negative Valence; Neurobiology; Pattern; Personal Satisfaction; Positive Valence; Prospective Studies; Psychopathology; Radial; Recruitment Activity; Reporting; Research; Rest; Risk; Staging; Structure; System; Testing; Thick; brain behavior; caregiving; early childhood; emotion dysregulation; emotion regulation; experience; functional outcomes; girls; gray matter; high risk; improved; infancy; maternal caregiving; neural circuit; neurodevelopment; neuroimaging; offspring; prospective; relating to nervous system; standardize measure; white matter

 DESCRIPTION (provided by applicant): The rapid development of the human brain, and its heightened sensitivity to environmental influences, in the first months of life determine critical brain-behavior relationships in childhood and across the lifespan. Despite evidence that the effects of poor caregiving on developing neurobiological systems underlying psychopathology risk may be most influential in the early years, little is known about the interface among neurobiological, affective and developmental areas of study in human infancy. In the proposed short-term prospective study, we wish to perform neuroimaging assessments in infancy (3 months), to provide a unique opportunity to identify prefrontal cortical-subcortical neural circuity structure and function associated with infant emotional reactivity at a critical stage in human neurodevelopment. In addition, we aim to examine the prospective relationships with infant emotional regulation capacity at 9 months, and the influence of maternal caregiving. We propose to identify 72 3-month-old infants of young, urban-living mothers at risk for compromised caregiving by virtue of their own negative parenting experiences, and dysregulated affect. The first aim of the proposed study is to identify neuroimaging measures of structure and intrinsic functional connectivity in emotional reactivity neural circuitry that are associated with negative and positive emotional reactivity in 3-month olds. We will examine the following three neuroimaging modalities in infants: 1) structural neuroimaging measures of prefrontal cortical and subcortical volumes and cortical thickness; 2) diffusion imaging measures of white matter structure in key tracts connecting prefrontal and subcortical, and prefrontal and other cortical, regions and 3) intrinsic (resting state) functional connectivity among these regions, and larger scale neural networks. The second aim is to determine prospective relationships between neural circuitry structure and intrinsic functional connectivity at 3 months and later emotional regulation at 9 months. The third aim is to determine the extent to which observed maternal caregiving behavior moderates the relationships in Aim 2. Exploratory analyses will examine the impact of infant gender upon brain-behavior relationships, and will also examine global neural connectivity in infants, and relationships with the above measures of infant emotional reactivity, 9-month emotional regulation, and maternal caregiving. By aiming to elucidate early neurobiological markers of infant emotional reactivity, relationships with subsequent emotional dysregulation, and the ways in which maternal caregiving impacts these brain-behavior relationships, the proposed research may ultimately provide neurobiological targets to guide early interventions to improve the health and well-being of at-risk children.

 描述（由申请人提供）：人类大脑的快速发育及其对环境影响的高度敏感性，在生命的最初几个月决定了儿童时期和整个生命周期的关键大脑行为关系。尽管有证据表明，不良的发育对神经生物学系统的影响，潜在的精神病理学风险可能是最有影响力的，在早年，很少有人知道在人类婴儿期的神经生物学，情感和发展领域的研究之间的接口。在拟议的短期前瞻性研究中，我们希望在婴儿期（3个月）进行神经影像学评估，以提供一个独特的机会，以确定前额叶皮质-皮质下神经环路的结构和功能与婴儿的情绪反应在人类神经发育的关键阶段。此外，我们的目的是检查与婴儿情绪调节能力在9个月的前瞻性关系，和母亲的影响。我们建议确定72个3个月大的婴儿的年轻，城市生活的母亲在风险的妥协，凭借自己的负面养育经验，和失调的影响。拟议的研究的第一个目的是确定神经影像学措施的结构和内在功能连接的情绪反应神经回路，与3个月奥尔兹的负面和积极的情绪反应。我们将研究以下三种婴儿神经影像学方式：1）前额叶皮质和皮质下体积和皮质厚度的结构神经影像学测量; 2）连接前额叶和皮质下以及前额叶和其他皮质区域的关键束中白色物质结构的扩散成像测量; 3）这些区域之间的内在（静息状态）功能连接，以及更大规模的神经网络。第二个目的是确定3个月时神经回路结构和内在功能连接之间的前瞻性关系，以及9个月时的情绪调节。第三个目标是确定在何种程度上观察到的母亲的养育行为缓和的关系，在目标2。探索性分析将研究婴儿性别对大脑行为关系的影响，还将研究婴儿的整体神经连接，以及与上述婴儿情绪反应、9个月情绪调节和母亲行为的关系。通过旨在阐明婴儿情绪反应的早期神经生物学标志物，与随后的情绪失调的关系，以及母亲分娩影响这些大脑行为关系的方式，拟议的研究可能最终提供神经生物学目标，以指导早期干预措施，以改善高危儿童的健康和福祉。

项目成果

The Impact of Caregiving on the Association Between Infant Emotional Behavior and Resting State Neural Network Functional Topology.

护理对婴儿情绪行为与静息态神经网络功能拓扑之间关联的影响。

• DOI: 10.3389/fpsyg.2018.01968
• 发表时间: 2018
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Hanford,LindsayC;Schmithorst,VincentJ;Panigrahy,Ashok;Lee,Vincent;Ridley,Julia;Bonar,Lisa;Versace,Amelia;Hipwell,AlisonE;Phillips,MaryL
• 通讯作者: Phillips,MaryL