UCSD Cancer Center Training Program in Drug Development

7.项目总结/摘要 此更新申请寻求资金，以继续非常成功的癌症治疗培训（CT 2） 项目在摩尔综合癌症中心在加州大学圣地亚哥分校。使命 CT 2计划的目标是培养博士和医生科学家，他们将成为下一代的领导者 在癌症治疗和诊断领域，成功翻译所需的每个主要步骤中， 将实验室发现转化为安全有效的治疗药物和诊断方法。CT2 培训的目的是使受训者在肿瘤治疗领域发挥关键的领导作用。的 CT 2计划的27名教师都是癌症中心的成员，分布在10个部门， 医学院，斯克里普斯海洋研究所或一般校园。每个教师导师都是一个 有成就的调查员和教育家，有培养优秀博士后研究员的历史。各有 大量的同行评审的癌症或癌症相关的研究资金。所有参与的教师都是 进行转化研究，并已被选中，因为他们在新的癌症治疗的兴趣。 该计划被广泛纳入癌症中心的其他癌症相关活动， 加州大学圣地亚哥分校我们的目标是在这个为期两年的项目中招募和留住8名MD和博士科学家， 他们的职业生涯在新的癌症药物的开发或诊断需要指导使用这些 个性化医疗时代的药物。培训计划有3个组成部分：1）完成 正式的教学课程，涵盖药物开发过程中必不可少的工具; 2）进行 在教师导师的指导下进行药物或诊断开发研究项目;以及，3）要求 参加美国癌症研究协会年会或同等的国家会议 药物开发会议。学员还将参加癌症中心和部门 研讨会，研究回合和期刊俱乐部，以扩大他们对癌症研究的理解的广度， 并准备正式的项目计划和实践或真实的赠款申请，供执行委员会审查。 制定了方法，确保所有受训人员都得到关于负责任行为原则的适当指导 研究和科学的完整性。在全国范围内招募受训人员，并作出特别努力， 保留特殊的少数族裔、妇女和处境不利的候选人。在其运作的头10年中， CT 2计划吸引了来自全国主要研究型大学以及 Gradate生物医学科学和外科，血液学/肿瘤学和儿科临床培训课程。 该计划非常成功，癌症中心已经建立了一个额外的平行计划， 由捐款资助的癌症治疗研究金。

7. PROJECT SUMMARY/ABSTRACT This renewal application seeks funding to continue the highly successful Cancer Therapeutics Training (CT2) Program at the Moores Comprehensive Cancer Center at the University of California, San Diego. The mission of the CT2 program is to train the PhD and physician-scientists who will become the next generation of leaders in the field of cancer therapeutics and diagnostics in each of the major steps required for successful translation of laboratory-based discoveries into safe and effective therapeutic agents and diagnostic modalities. The CT2 training is designed to position trainees to play key leadership roles in the field of oncology therapeutics. The 27 faculty of the CT2 Program are all Members of the Cancer Center and are based in 10 departments in the School of Medicine, the Scripps Institute of Oceanography or the general campus. Each faculty mentor is an accomplished investigator and educator with a history of training superb post-doctoral fellows. Each has substantial peer-reviewed cancer or cancer-related research funding. All of the participating faculty are conducting translational research and have been selected because of their interest in new cancer therapeutics. This program is extensively integrated into the other cancer related activities of the Cancer Center and of UCSD. The goal is to recruit and retain 8 MD and PhD scientists in this two-year program that will position them for careers in the development of new cancer drugs or the diagnostics needed to guide the use of these drugs in the era of personalized medicine. The training program has 3 components: 1) the completion of formal didactic teaching sessions that cover tools essential to the drug development process; 2) the conduct of a drug or diagnostic development research project under the direction of a faculty mentor; and, 3) required participation in the annual meeting of the American Association for Cancer Research or an equivalent national drug development meeting. Trainees are also expected to participate in Cancer Center and Departmental seminars, research rounds and journal clubs to expand the breadth of their understanding of cancer research, and prepare formal project plans and practice or real grant applications for review by the Executive Committee. Methods are in place to ensure that all trainees are properly instructed in the principles of responsible conduct of research and scientific integrity. Trainees are recruited nationwide and special efforts are made recruit and retain exceptional minority, women and disadvantaged candidates. During its first 10 years of operation the CT2 Program has drawn trainees from major research universities across the country as well as from the Gradate Biomedical Sciences and Surgery, Hematology/Oncology, and Pediatric clinical training programs. This Program has been so successful that the Cancer Center has established a parallel program of additional fellowships in cancer therapeutics funded by donations.