Institutional Center Cores for Advanced Neuroimaging

描述（由申请人提供）：本提案的总体目标是建立NINDS机构中心核心设施，以增加明尼苏达大学磁共振研究中心（CMRR）生物医学成像的独特资源，从而最大限度地利用和影响大量NINDS资助的正常脑功能和神经系统疾病研究项目。这一目标是基于这样的前提，即在过去二十年中的发展已经产生了过多的磁共振（MR）技术，例如功能性脑成像（fMRI）、神经化学光谱、灌注成像、扩散成像等，其为人类大脑和人类疾病状态的动物模型的研究提供了不可或缺的和不可用的测量能力。然而，这些技术的最佳使用需要先进的仪器、独特的专业知识和复杂的辅助功能，包括采用经典技术（例如电生理学和组织学）和其他成像模式（如PET）的补充测量。这些仪器和方法，特别是在尖端，在个别实验室几乎是不可能的，需要在自旋物理，射频工程，信号和图像处理，以及脑科学领域的跨学科互动。该补助金的目的是在CMRR的合作，多学科和互动研究环境中提供这种访问，以丰富大量正在进行的NINDS资助的研究项目的有效性并促进新的研究方向。

DESCRIPTION (provided by applicant): The general aim of this proposal is to establish NINDS Institutional Center Core facilities that will augment the unique resources that exist at the Center for Magnetic Resonance Research (CMRR), University of Minnesota, for biomedical imaging, so as to maximize their utilization and impact on a large number of NINDS funded research projects on normal brain function and neurological disorders. This aim is based on the premise that developments in the last two decades have generated a plethora of magnetic resonance (MR) techniques, such as functional brain imaging (fMRI), neurochemical spectroscopy, perfusion imaging, diffusion imaging etc., that provide indispensable and otherwise unavailable measurement capabilities for studies of the brain in humans and in animal models of human diseased states. However, optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities that include complementary measurements employing classical techniques (e.g. electrophysiology, and histology) and other imaging modalities such as PET. Access to these instrumentation and methodologies, especially at the cutting-edge, is virtually impossible in individual labs and requires interdisciplinary interactions in the area of spin-physics, RF engineering, signal and image processing, and brain sciences. The aim of this grant is to provide this access within the cooperative, multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.