CONSOLE FOR 10.5 TESLA WHOLE BODY MRI SYSTEM

描述（由申请人提供）：在过去的二十年中，大量的磁共振（MR）技术，如功能磁共振成像（fMRI）、灌注成像、磁共振波谱等，在生物医学研究和临床实践中发挥了不可或缺的作用。在我们的实验室，明尼苏达大学磁共振研究中心（CMRR），这些方法的发展与高场磁共振的发展有着复杂的联系，从1990年的4特斯拉(T)（大约同时安装的前三个系统之一）和1999年的7特斯拉（第一个这样的系统）开始，最终导致研究界和临床磁共振平台制造商对7t的兴趣迅速增长。由于信噪比（SNR）和对比度机制的综合增益，在超高磁场下可以实现显着的改进，现在预计该磁场下的成像也将影响临床实践，并且这种“临床”扫描仪是不可避免的。本提案的目的是进一步探索这些成果，并通过建立10.5特斯拉（~450 MHz质子频率）磁共振成像和光谱仪器进一步推动磁共振研究的界限，该仪器具有足够大的孔径（83厘米透明孔径），可以对人类大脑以及人体躯干和四肢进行研究。10.5 T比目前最常用的超高场平台（即7特斯拉）有了显著的提高。目前世界上没有这样的工具。一个11.7 T， 68 cm孔径（~500 MHz）的“仅头部”系统计划用于NIH的内部研究，法国的一项主要努力旨在开发基于更大孔径磁铁的类似系统。我们提出要求的理由主要是基于我们实验室的证明，即(1)超高磁场提供了低磁场无法提供的独特信息；(2)这些信息不仅可以在人脑中获得，而且通过适当的技术发展，也可以在人体躯干和四肢中获得；(3)这些信息对基础生物医学和转化研究以及临床医学都很有用。如果成功，高等教育学院的资助将把这台先进的仪器放在一个实验室，该实验室是一个生物技术研究中心（BTRC），用于高场磁共振研究，并拥有适当的跨学科专业知识和基础设施，以最大限度地利用它。认识到这一点，明尼苏达大学将提供资金购买磁铁，并建立必要的空间来安装它。HEI赠款要求为其余设备提供资金，以便将磁体转换为综合磁流变系统，并用于适当的射频和磁场屏蔽。

DESCRIPTION (provided by applicant): In the last two decades, a plethora of magnetic resonance (MR) techniques, such as functional magnetic resonance imaging (fMRI), perfusion imaging, MR spectroscopy, etc. have come to play an indispensable role in biomedical research, as well as in clinical practice. In our laboratory, the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota, the evolution of such methods has been intricately tied with the development of high field MR, starting with 4 Tesla (T) in 1990 (one of first three installed at about the same time) and 7 Tesla in 1999 (the first such system), ultimately leading to the rapidly growing interest in 7 T both in the research community and the manufacturers of clinical MR platforms. Based on the dramatic improvements that can be realized at the ultrahigh fields due to combined gains in signal-to-noise ratio (SNR) and contrast mechanisms, it is now anticipated that imaging at this magnetic field will also impact clinical practice and that such a "clinical" scanner is inevitable. The aim of this proposal is to explore these gains further and push the boundaries of MR research further by establishing a 10.5 Tesla (~450 MHz proton frequency) MR imaging and spectroscopy instrument with sufficiently large bore size (83 cm clear bore) to perform studies on the human brain as well as the human torso and extremities. 10.5 T represents a significant increase over the current, most commonly available ultrahigh field platform, i.e. 7 Tesla. No such instrument currently exists in the world. An 11.7 T, 68 cm bore (~500 MHz) "head only" system is planned for NIH intramural research and a major effort in France aims to develop a similar system based on a larger bore magnet. The rational for our request is based on the demonstration, largely coming from our laboratory, that (i) ultrahigh fields provide unique information that is not available at lower magnetic fields, (ii) such information can be obtained not only in the human brain but, with appropriate technological developments, in the human torso and extremities as well, and (iii) such information is useful both for basic biomedical and translational research as well as for clinical medicine. If successful, this HEI grant will place this advanced instrument in a laboratory that is funded as a Biotechnology Research Center (BTRC) for high field MR research and a laboratory with appropriate interdisciplinary expertise and infrastructure to maximally utilize it. Recognizing this, the University of Minnesota will provide the funds to acquire the magnet and build the necessary space to install it. Funds are requested in this HEI grant for the rest of the equipment to convert the magnet into an integrated MR system and for the appropriate RF and magnetic field shielding. ) PUBLIC HEALTH RELEVANCE: Since its discovery, magnetic resonance imaging (MRI) has come to play an indispensible role in clinical medicine as a diagnostic tool and in biomedical research aimed at understanding normal organ functions and mechanisms underlying human diseases. This proposal aims to push the boundaries of MR technology further by establishing a 10.5 Tesla MR imaging and spectroscopy instrument with sufficiently large bore size (83 cm clear bore) to perform studies on the human body. This instrument will be first of its kind in the world and the highest field available for research in both the human brain as well as the human torso and extremities.