Cell Biology and Immunology of Persistent Infection

 描述(由申请人提供)：请求支持由Herbert(Skip)W.Virgin、E.John Wherry、Anne O‘Garra和Andrea Lynn Cox组织的题为持续感染的细胞生物学和免疫学的Keystone研讨会。会议将于2016年1月31日至2月4日在加拿大艾伯塔省班夫举行。持续感染是世界各地发病率和死亡率的主要来源。然而，越来越清楚的是，细菌微生物组、病毒体和真菌生物组可以对宿主起到有益的作用。病原体的慢性感染代表着灭菌免疫的失败，但导致持续存在的机制以及宿主健康和感染引起的疾病之间的平衡尚未完全了解。最近的发现表明，感染有机体和宿主对感染的反应的多种成分决定了感染结果，这表明必须将一系列学科结合在一起才能理解 慢性感染的基本机制。这次研讨会旨在让不同的 在各自领域的尖端研究人员社区，了解是否以及如何操纵持续感染以预防疾病和增进健康。

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Cell Biology and Immunology of Persistent Infection, organized by Herbert (Skip) W. Virgin, E. John Wherry, Anne O'Garra and Andrea Lynn Cox. The meeting will be held in Banff, Alberta, Canada from January 31-February 4, 2016. Persistent infections are a major source of morbidity and mortality around the world. However, it is increasingly clear that the bacterial microbiome, the virome, and the mycobiome can have beneficial roles for the host. Chronic infections with pathogens represent a failure of sterilizing immunity, but the mechanisms responsible for persistence and the balance between host health and disease resulting from infection are not completely understood. Recent discoveries reveal that multiple components of both the infecting organism and the host response to infection determine infection outcome, illustrating that a range of disciplines must be brought together to understand the fundamental mechanisms of chronic infection. This symposium is designed to bring together diverse communities of researchers at the cutting edge of their fields to understand whether and how to manipulate persistent infections to prevent disease and enhance health.