Metabolomics Core

项目摘要/摘要 – 代谢组学核心 代谢组学核心 (MC) 的目标仍然是促进对代谢和代谢的理解 通过使用尖端技术，与铁、血红素、造血和红细胞生物学相关的通量， 新开发的方法和生物信息学分析。随着 MC 的需求不断扩大 进一步实现了该技术对模型系统的适用性。我们的MC核心，已经存在了 15 年来，快速发展以满足用户需求，包括广泛教育的发展 （研讨会），通过 CIHD 丰富活动向所有用户提供，高吞吐量 样品处理，改进通量分析以及利用生物信息工具来处理数据和解释 结果。我们增加了专注于代谢组学、脂质组学和生物信息学以及 增加尖端仪器（例如高分辨率轨道阱仪器）以满足对高分辨率的需求 末端同位素示踪剂和通量分析。核心将继续完善其方法，标准化报告 使用开发的定制数据分析报告软件并为成功的人提供教育机会 研究者发起的研究和进步。

PROJECT SUMMARY/ABSTRACT – Metabolomics Core The goals of the Metabolomics Core (MC) remain to advance the understanding of metabolism and metabolic flux in relation to iron, heme, hematopoeisis and red cell biology through the use of cutting edge technology, newly developed methodologies and Bioinformatic analyses. The need for the MC continues to expand as the applicability of this technology to model systems is further realized. Our MC core, which has been in existence for over 15 years, has rapidly evolved to meet user demand including the development of extensive education (workshops), which are made available to all users through the CIHD Enrichment activities, high throughput sample processing, improve flux analysis and utilization of bioinformatic tools to process data and interpret results. We have increased personnel focused on metabolomics, lipidomics and bioinformatics as well as adding cutting edge instrumentation (e.g. high resolution orbitrap instrument) to satisfy the demand for high end isotope tracer and flux analysis. The Core will continue to refine its methodologies, standardize reporting using developed custom data analysis reporting software and provide educational opportunities for successful investigator-initiated research and advancement.