Metabolomics Core

项目摘要/摘要-代谢组学核心 代谢组学核心(MC)的目标仍然是促进对新陈代谢和代谢的理解 通过使用尖端技术在铁、血红素、造血和红细胞生物学方面的流量， 新开发的方法学和生物信息学分析。对MC的需求随着 进一步实现了该技术在建模系统中的适用性。我们的MC核心，它已经存在 在超过15年的时间里，迅速发展以满足用户需求，包括发展广泛的教育 (讲习班)，通过CIHD浓缩活动向所有用户提供，产量高 样品处理，改进通量分析和生物信息工具的利用，以处理数据和解释 结果。我们增加了专注于代谢组学、脂类组学和生物信息学的人员以及 增加尖端仪器(例如高分辨率Orbitrap仪器)，以满足高 末端同位素示踪剂和通量分析。核心小组将继续改进其方法，使报告标准化 使用开发的定制数据分析报告软件，并提供成功的教育机会 研究人员发起的研究和进展。

PROJECT SUMMARY/ABSTRACT – Metabolomics Core The goals of the Metabolomics Core (MC) remain to advance the understanding of metabolism and metabolic flux in relation to iron, heme, hematopoeisis and red cell biology through the use of cutting edge technology, newly developed methodologies and Bioinformatic analyses. The need for the MC continues to expand as the applicability of this technology to model systems is further realized. Our MC core, which has been in existence for over 15 years, has rapidly evolved to meet user demand including the development of extensive education (workshops), which are made available to all users through the CIHD Enrichment activities, high throughput sample processing, improve flux analysis and utilization of bioinformatic tools to process data and interpret results. We have increased personnel focused on metabolomics, lipidomics and bioinformatics as well as adding cutting edge instrumentation (e.g. high resolution orbitrap instrument) to satisfy the demand for high end isotope tracer and flux analysis. The Core will continue to refine its methodologies, standardize reporting using developed custom data analysis reporting software and provide educational opportunities for successful investigator-initiated research and advancement.