Metabolomics Core

代谢组学核心

• 批准号: 10206674
• 负责人: JAMES Eric COX
• 金额: $ 10.64万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-05 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10206674
• 关键词: Address; Bioinformatics; Biological Models; Cellular biology; Communication; Communities; Computer software; Custom; Data; Data Analyses; Data Reporting; Data Set; Development; Disease; Education; Educational workshop; Erythrocytes; Goals; Hematology; Hematopoiesis; Heme; Heme Iron; Homeostasis; Human Resources; Individual; Investigator-Initiated Research; Iron; Isotopes; Mass Spectrum Analysis; Metabolic; Metabolic Pathway; Metabolism; Methodology; Methods; Output; Paper; Pathway interactions; Persons; Porphyrins; Postdoctoral Fellow; Preparation; Process; Publishing; Reporting; Research Personnel; Resolution; Resources; Sampling; Site; Software Tools; Standardization; Students; Techniques; Technology; Tracer; Universities; Utah; base; bioinformatics tool; cell type; improved; instrument; instrumentation; lipidomics; member; metabolomics; online course; rapid test; response; small molecule; social media; success; tool; training opportunity; trend; virtual

PROJECT SUMMARY/ABSTRACT – Metabolomics Core The goals of the Metabolomics Core (MC) remain to advance the understanding of metabolism and metabolic flux in relation to iron, heme, hematopoeisis and red cell biology through the use of cutting edge technology, newly developed methodologies and Bioinformatic analyses. The need for the MC continues to expand as the applicability of this technology to model systems is further realized. Our MC core, which has been in existence for over 15 years, has rapidly evolved to meet user demand including the development of extensive education (workshops), which are made available to all users through the CIHD Enrichment activities, high throughput sample processing, improve flux analysis and utilization of bioinformatic tools to process data and interpret results. We have increased personnel focused on metabolomics, lipidomics and bioinformatics as well as adding cutting edge instrumentation (e.g. high resolution orbitrap instrument) to satisfy the demand for high end isotope tracer and flux analysis. The Core will continue to refine its methodologies, standardize reporting using developed custom data analysis reporting software and provide educational opportunities for successful investigator-initiated research and advancement.

项目总结/摘要-代谢组学核心 代谢组学核心（MC）的目标仍然是促进对代谢和代谢产物的理解。 通量与铁，血红素，造血和红细胞生物学通过使用尖端技术， 新开发的方法和生物信息学分析。对MC的需求继续扩大， 进一步实现了该技术对建模系统的适用性。我们的MC核心， 在过去的15年里，已经迅速发展，以满足用户的需求，包括发展广泛的教育 通过CIHD的浓缩活动向所有用户提供， 样本处理，改进通量分析，利用生物信息学工具处理数据并解释 结果我们增加了专注于代谢组学、脂质组学和生物信息学以及 增加尖端仪器（如高分辨率轨道阱仪器），以满足高分辨率的需求。 末端同位素示踪和通量分析。核心小组将继续完善其方法，使报告标准化， 使用开发的定制数据分析报告软件，并为成功的 研究者发起的研究和进步。