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Neurobiological Reactivity, Allostatic Load and Depression in Mexican Youth

墨西哥青少年的神经生物学反应、稳态负荷和抑郁症

基本信息

批准号：
9101841
负责人：
Amanda E Guyer
金额：
$ 48.56万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-06 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9101841
关键词：
15 year old 16 year old 19 year old Acute Adolescence Adolescent Adult Age Alcohol or Other Drugs use Anxiety Anxiety Disorders Attention Behavior Behavioral Brain California Chronic Clinical Cognitive Communities Comorbidity Cues Data Data Collection Depressed mood Depressive disorder Development Diagnosis Economics Epidemiology Ethnic group Face Family Female Functional Magnetic Resonance Imaging Functional disorder Funding Gender Healthcare Hormones Hyperactive behavior Incentives Knowledge Latino Link Longitudinal Studies MRI Scans Major Depressive Disorder Measures Mediation Mediator of activation protein Mental Depression Mental Health Mental disorders Mexican Minority Minority Groups Modeling Mood Disorders National Institute of Drug Abuse Neurobiology Neurotic Disorders Pattern Personality Physiological Physiology Population Predisposition Prevalence Prevention program Preventive Intervention Process Psychopathology Psychophysiology Race Recruitment Activity Request for Proposals Rewards Risk Risk Factors Sampling Social Environment Source Stress Symptoms System Testing Time Variant Workload Youth allostatic load base biopsychosocial child depression comorbid depression contextual factors depressive symptoms disability disparity reduction ethnic minority population experience flexibility gender difference high risk indexing intervention program model development neurobiological mechanism prospective psychiatric symptom psychosocial racial and ethnic relating to nervous system resilience response social social stress stressor young adult

项目摘要

DESCRIPTION (provided by applicant): This proposal requests funds to examine allostatic load as a potential mechanism in the development of depression in Mexican-origin adolescents. Allostatic load is the loss of flexibility in how physiological systems respond to stressful experiences. High levels of allostatic load have been identified in Mexican origin adults who experience economic, familial, workload, and acculturative stress, yet allostatic load has not been examined from a dynamic, multi-systemic or longitudinal perspective in this ethnic group. Because adolescence increases the risk for the development of depression, longitudinal data are needed to understand how allostatic load and depression change over time in Mexican-origin youth, who 1) are among the largest ethnic minority group in the US, 2) face high risk for depression, and 3) experience high levels of stress. A comprehensive assessment of dynamic, multi-systemic neurobiological reactivity to incentives and social stressors, two symptom-specific contexts, is proposed to assess allostatic load. Our proposed study will add these assessments to an existing, ongoing longitudinal study of the development of psychopathology and adjustment in 673 adolescents of Mexican origin (California Families Project [CFP]; 2R01DA017902-06; Contact PI: R. Conger). From this larger sample, we will identify 250 youths (50% female) with elevated risk for depression based on symptom counts and neuroticism at age 15 years. At ages 16 and 18 years, these selected youth will complete functional magnetic resonance imaging scans while adrenocortical, immunological and autonomic psychophysiological data are collected simultaneously. We expect that high neurobiological reactivity to social stressors and low reactivity to incentives will relate to high levels of depression symptoms in Mexican-origin adolescents. We also hypothesize that neurobiological reactivity will be a more effective index of allostatic load in adolescence than a more traditional additive measure of allostatic load using elevated static measures of physiology. Importantly, by integrating the proposed study and the existing CFP study, we will capitalize on the extensive available data on risk and protective factors (e.g., cognitive, personality, behavioral, contextual and cultural) offered by the CFP. These data on risk and protective factors will support proposed analyses based on biopsychosocial models of the development of depression in Mexican-origin adolescents. We will examine allostatic load as a mediator and a moderator of associations among risk and protective social-contextual factors and changes in depression. Results of the study are expected to inform the development of more effective and culturally sensitive prevention programs for an important, growing and understudied population. The existence of the ongoing CFP study (through 2015) by Dr. Conger and colleagues, with a committed and representative community sample of Mexican origin families, makes this proposal feasible. The timing of the proposal is critical, as youths will be 16 years old when the start of neurobiologica data collection is planned. Consequently, this will be one of the only prospective longitudinal studies of allostatic load as a mechanism of the development of depression in Mexican-origin adolescents.

描述(由申请者提供)：这项提案要求提供资金，以研究在墨西哥裔青少年中，等静负荷是抑郁症发展的一个潜在机制。非平衡负荷是指生理系统对应激体验的反应失去灵活性。在经历了经济、家庭、工作负荷和文化适应压力的墨西哥裔成年人中，已经发现了高水平的动态平衡负荷，但在这个民族中，动态平衡负荷还没有从动态、多系统或纵向的角度进行研究。因为青春期增加了患抑郁症的风险，所以需要纵向数据来了解墨西哥裔青年的非稳态负荷和抑郁是如何随着时间的推移而变化的，他们1)是美国最大的少数民族群体之一，2)面临着高抑郁风险，3)经历着高水平的压力。提出了一种动态的、多系统的神经生物学反应对刺激和社会应激源的综合评估，这是两种症状具体情况下的评估，用于评估异位负荷。我们建议的研究将把这些评估添加到现有的、正在进行的关于673名墨西哥裔青少年精神病理学和适应发展的纵向研究中(加州家庭项目[CFP]；2R01DA017902-06；联系Pi：R.Conger)。从这个更大的样本中，我们将根据15岁时的症状计数和神经质来确定250名年轻人(50%为女性)患抑郁症的风险增加。在16岁和18岁时，这些被选中的年轻人将完成功能性磁共振成像扫描，同时收集肾上腺皮质、免疫学和自主神经心理生理学数据。我们预计，对社会应激源的高神经生物学反应性和对诱因的低反应性将与墨西哥裔青少年抑郁症状的高水平有关。我们还假设，神经生物反应性将是青春期恒定负荷的更有效的指标，而不是使用提高的静态生理学指标来衡量恒定负荷的更传统的相加指标。重要的是，通过整合拟议的研究和现有的CFP研究，我们将利用关于风险和保护因素(例如，认知、个性、行为、背景)的广泛可用数据和文化)由CFP提供。这些关于风险和保护因素的数据将支持基于墨西哥裔青少年抑郁症发展的生物心理社会模型的拟议分析。我们将考察等静负荷作为风险和保护性社会背景因素与抑郁症变化之间关联的中介和调节因素。这项研究的结果预计将为为重要的、不断增长的和未得到充分研究的人口制定更有效和更具文化敏感性的预防计划提供信息。康格博士和他的同事正在进行的CFP研究(到2015年)的存在，以及墨西哥裔家庭的承诺和代表性的社区样本，使这一提议可行。这项提议的时机至关重要，因为计划开始收集神经生物学数据时，年轻人将年满16岁。因此，这将是仅有的关于变态负荷作为墨西哥裔青少年抑郁发展机制的前瞻性纵向研究之一。