Characterizing neurodevelopmental trajectories of social-emotional processing circuitry in girls across adolescence

描述青春期女孩社会情感处理回路的神经发育轨迹

• 批准号: 9789954
• 负责人: Amanda E Guyer
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789954
• 关键词: Address; Adolescence; Adolescent; Adult; Affective; Age; Awareness; Behavior; Bilateral; Brain; Brain region; Caring; Child; Child Rearing; Clinical assessments; Data; Data Set; Detection; Development; Dimensions; Emotional; Emotions; Event; Expressed Emotion; Face; Feeling; Female Adolescents; Genetic; Goals; Growth; Impairment; Individual; Individual Differences; Lead; Life; Link; Longevity; Longitudinal Studies; Measures; Medial; Mental Depression; Mental Health; Mental disorders; Modeling; Motivation; National Institute of Mental Health; Neurobiology; Outcome; Patient Self-Report; Pattern; Perception; Persons; Plant Roots; Play; Population Heterogeneity; Prefrontal Cortex; Preventive Intervention; Problem Solving; Process; Psyche structure; Psychopathology; Research Domain Criteria; Risk; Role; Sample Size; Self-Direction; Shapes; Social Behavior; Social Class; Social Processes; Social support; Socialization; Structure of middle temporal gyrus; Testing; Thinking; Vacuum; Variant; Woman; base; brain behavior; brain circuitry; cingulate cortex; clinical care; clinically relevant; critical period; depressive symptoms; design; directed attention; early adolescence; emerging adult; emotion regulation; emotional behavior; experience; girls; improved; innovation; mental development; neural circuit; neurodevelopment; neuroimaging; prospective; psychologic; psychosocial; rate of change; relating to nervous system; response; satisfaction; showing emotion; skills; social; therapy design; young adult

Project Summary Interpersonal functioning is vital across a range of mental health outcomes, with particular significance for adolescent girls. Adolescence is a critical period for promoting or hindering development of adaptive interpersonal functioning due to dramatic changes in social behaviors and significant maturation of brain regions that facilitate social-emotional processing. Despite this importance, very few prospective, longitudinal studies have used repeated functional neuroimaging data to chart the trajectory of connectivity of social-emotional brain regions across adolescence. The proposed project is rigorously designed to use the Research Domain Criteria (RDoC) framework for Social Processes to address a gap in the field about how functional connectivity of social- emotional brain regions during introspection changes within the same girls across several years of adolescence. First, we will characterize trajectories of connectivity between the mPFC, precuneus/posterior cingulate cortex, and bilateral middle temporal gyrus across ages 16-18. We will then determine if change in functional connectivity from age 16 to 18 promotes or hinders girls' effective interpersonal functioning at age 18. Finally, we will test whether girls' emotion expression and emotion socialization experiences across ages 9-13 moderate the association between trajectories of brain connectivity and interpersonal functioning. We capitalize on an unprecedented existing dataset of neuroimaging, psychosocial functioning, and social-emotional behavior collected on 185 girls from the ages of 9-18 years who are part of the Pittsburgh Girls Study of Emotion. The project will investigate multiple units of analysis (e.g., circuits, paradigms, behavior, self-reports) of the RDoC Affiliation and Perception/Understanding of Self and Others constructs, and situates these units of analysis in the context of neurodevelopment and environmental experiences. Several aspects of the proposed study will allow us to generate highly impactful data. First, the sample size would be one of the largest to date for examining trajectories of task-based functional connectivity (e.g., latent growth, moderation). Second, potential findings can inform the development of more precise treatments and interventions designed to target affective processes, socialization and interpersonal functioning of adolescent girls at risk for psychopathology. Third, assessments of emotional socialization, emotion expression and self-reported interpersonal functioning are completed within each subject, providing an opportunity to test more refined models of how functional connectivity underlying psychological processes may become disrupted and lead to poor interpersonal functioning. Fourth, leveraging existing prospectively collected data provides an unprecedented, and economical, test of individual factors that may moderate brain-behavior associations. This will be one of the most comprehensive and rigorous tests of the associations among early adolescent emotion socialization and emotion expression, trajectories of brain connectivity linked to introspection across adolescence, and interpersonal functioning in young adulthood.

项目摘要 人际功能在一系列心理健康结果中至关重要，对 青春期的女孩。青春期是促进或阻碍适应能力发展的关键时期 社交行为的戏剧性变化和大脑区域的显著成熟导致的人际功能 这促进了社交情绪的处理。尽管这很重要，但很少有前瞻性的纵向研究 已经使用重复的功能神经成像数据来绘制社交-情绪大脑的连接轨迹 青春期的各个区域。建议的项目是严格按照研究领域标准设计的 (RDoC)社交流程框架，以解决该领域有关社交功能连接如何- 在青春期的几年里，同一个女孩在内省过程中的情绪大脑区域发生了变化。 首先，我们将描述mPFC、楔前/后扣带回皮质、 以及16-18岁的双侧颞中回。然后，我们将确定功能连接性是否发生变化 从16岁到18岁促进或阻碍女孩在18岁时的有效人际功能。最后，我们将测试 9-13岁女生的情绪表达和情绪社会化经历是否具有调节作用 大脑连接轨迹和人际功能之间的联系。我们利用了一个 史无前例的现有神经成像、心理社会功能和社会情绪行为数据集 收集了185名9-18岁的女孩，她们是匹兹堡女孩情感研究的一部分。这个 项目将调查RDoC的多个分析单元(例如，电路、范例、行为、自我报告) 自我和他人的从属关系和感知/理解构成，并将这些分析单位置于 神经发展和环境体验的背景。拟议研究的几个方面将 使我们能够生成极具影响力的数据。首先，样本大小将是迄今为止检查的最大样本之一 基于任务的功能连接的轨迹(例如，潜在增长、适度)。其次，潜在的发现可能 为开发更精确的治疗和干预措施提供信息，旨在针对情感过程， 易患精神病的青春期女孩的社会化和人际功能。第三，评估 情绪社会化、情绪表达和自我报告的人际功能在 每个主题，提供了一个机会来测试更精细的模型，以了解功能连接性是如何 心理过程可能会被打乱，并导致人际功能不佳。第四，杠杆化 现有的前瞻性收集的数据提供了一种前所未有的、经济的个体因素测试， 可能会缓和大脑行为之间的联系。这将是最全面和最严格的考验之一 青春期早期情绪社会化与情绪表达、脑轨迹的关系 连通性与青春期的内省和青春期的人际功能有关。