权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Characterizing neurodevelopmental trajectories of social-emotional processing circuitry in girls across adolescence

描述青春期女孩社会情感处理回路的神经发育轨迹

基本信息

批准号：
9789954
负责人：
Amanda E Guyer
金额：
$ 7.85万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-21 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9789954
关键词：
Address Adolescence Adolescent Adult Affective Age Awareness Behavior Bilateral Brain Brain region Caring Child Child Rearing Clinical assessments Data Data Set Detection Development Dimensions Emotional Emotions Event Expressed Emotion Face Feeling Female Adolescents Genetic Goals Growth Impairment Individual Individual Differences Lead Life Link Longevity Longitudinal Studies Measures Medial Mental Depression Mental Health Mental disorders Modeling Motivation National Institute of Mental Health Neurobiology Outcome Patient Self-Report Pattern Perception Persons Plant Roots Play Population Heterogeneity Prefrontal Cortex Preventive Intervention Problem Solving Process Psyche structure Psychopathology Research Domain Criteria Risk Role Sample Size Self-Direction Shapes Social Behavior Social Class Social Processes Social support Socialization Structure of middle temporal gyrus Testing Thinking Vacuum Variant Woman base brain behavior brain circuitry cingulate cortex clinical care clinically relevant critical period depressive symptoms design directed attention early adolescence emerging adult emotion regulation emotional behavior experience girls improved innovation mental development neural circuit neurodevelopment neuroimaging prospective psychologic psychosocial rate of change relating to nervous system response satisfaction showing emotion skills social therapy design young adult

项目摘要

Project Summary Interpersonal functioning is vital across a range of mental health outcomes, with particular significance for adolescent girls. Adolescence is a critical period for promoting or hindering development of adaptive interpersonal functioning due to dramatic changes in social behaviors and significant maturation of brain regions that facilitate social-emotional processing. Despite this importance, very few prospective, longitudinal studies have used repeated functional neuroimaging data to chart the trajectory of connectivity of social-emotional brain regions across adolescence. The proposed project is rigorously designed to use the Research Domain Criteria (RDoC) framework for Social Processes to address a gap in the field about how functional connectivity of social- emotional brain regions during introspection changes within the same girls across several years of adolescence. First, we will characterize trajectories of connectivity between the mPFC, precuneus/posterior cingulate cortex, and bilateral middle temporal gyrus across ages 16-18. We will then determine if change in functional connectivity from age 16 to 18 promotes or hinders girls' effective interpersonal functioning at age 18. Finally, we will test whether girls' emotion expression and emotion socialization experiences across ages 9-13 moderate the association between trajectories of brain connectivity and interpersonal functioning. We capitalize on an unprecedented existing dataset of neuroimaging, psychosocial functioning, and social-emotional behavior collected on 185 girls from the ages of 9-18 years who are part of the Pittsburgh Girls Study of Emotion. The project will investigate multiple units of analysis (e.g., circuits, paradigms, behavior, self-reports) of the RDoC Affiliation and Perception/Understanding of Self and Others constructs, and situates these units of analysis in the context of neurodevelopment and environmental experiences. Several aspects of the proposed study will allow us to generate highly impactful data. First, the sample size would be one of the largest to date for examining trajectories of task-based functional connectivity (e.g., latent growth, moderation). Second, potential findings can inform the development of more precise treatments and interventions designed to target affective processes, socialization and interpersonal functioning of adolescent girls at risk for psychopathology. Third, assessments of emotional socialization, emotion expression and self-reported interpersonal functioning are completed within each subject, providing an opportunity to test more refined models of how functional connectivity underlying psychological processes may become disrupted and lead to poor interpersonal functioning. Fourth, leveraging existing prospectively collected data provides an unprecedented, and economical, test of individual factors that may moderate brain-behavior associations. This will be one of the most comprehensive and rigorous tests of the associations among early adolescent emotion socialization and emotion expression, trajectories of brain connectivity linked to introspection across adolescence, and interpersonal functioning in young adulthood.