Characterizing neurodevelopmental trajectories of social-emotional processing circuitry in girls across adolescence

描述青春期女孩社会情感处理回路的神经发育轨迹

• 批准号: 9789954
• 负责人: Amanda E Guyer
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789954
• 关键词: Address; Adolescence; Adolescent; Adult; Affective; Age; Awareness; Behavior; Bilateral; Brain; Brain region; Caring; Child; Child Rearing; Clinical assessments; Data; Data Set; Detection; Development; Dimensions; Emotional; Emotions; Event; Expressed Emotion; Face; Feeling; Female Adolescents; Genetic; Goals; Growth; Impairment; Individual; Individual Differences; Lead; Life; Link; Longevity; Longitudinal Studies; Measures; Medial; Mental Depression; Mental Health; Mental disorders; Modeling; Motivation; National Institute of Mental Health; Neurobiology; Outcome; Patient Self-Report; Pattern; Perception; Persons; Plant Roots; Play; Population Heterogeneity; Prefrontal Cortex; Preventive Intervention; Problem Solving; Process; Psyche structure; Psychopathology; Research Domain Criteria; Risk; Role; Sample Size; Self-Direction; Shapes; Social Behavior; Social Class; Social Processes; Social support; Socialization; Structure of middle temporal gyrus; Testing; Thinking; Vacuum; Variant; Woman; base; brain behavior; brain circuitry; cingulate cortex; clinical care; clinically relevant; critical period; depressive symptoms; design; directed attention; early adolescence; emerging adult; emotion regulation; emotional behavior; experience; girls; improved; innovation; mental development; neural circuit; neurodevelopment; neuroimaging; prospective; psychologic; psychosocial; rate of change; relating to nervous system; response; satisfaction; showing emotion; skills; social; therapy design; young adult

Project Summary Interpersonal functioning is vital across a range of mental health outcomes, with particular significance for adolescent girls. Adolescence is a critical period for promoting or hindering development of adaptive interpersonal functioning due to dramatic changes in social behaviors and significant maturation of brain regions that facilitate social-emotional processing. Despite this importance, very few prospective, longitudinal studies have used repeated functional neuroimaging data to chart the trajectory of connectivity of social-emotional brain regions across adolescence. The proposed project is rigorously designed to use the Research Domain Criteria (RDoC) framework for Social Processes to address a gap in the field about how functional connectivity of social- emotional brain regions during introspection changes within the same girls across several years of adolescence. First, we will characterize trajectories of connectivity between the mPFC, precuneus/posterior cingulate cortex, and bilateral middle temporal gyrus across ages 16-18. We will then determine if change in functional connectivity from age 16 to 18 promotes or hinders girls' effective interpersonal functioning at age 18. Finally, we will test whether girls' emotion expression and emotion socialization experiences across ages 9-13 moderate the association between trajectories of brain connectivity and interpersonal functioning. We capitalize on an unprecedented existing dataset of neuroimaging, psychosocial functioning, and social-emotional behavior collected on 185 girls from the ages of 9-18 years who are part of the Pittsburgh Girls Study of Emotion. The project will investigate multiple units of analysis (e.g., circuits, paradigms, behavior, self-reports) of the RDoC Affiliation and Perception/Understanding of Self and Others constructs, and situates these units of analysis in the context of neurodevelopment and environmental experiences. Several aspects of the proposed study will allow us to generate highly impactful data. First, the sample size would be one of the largest to date for examining trajectories of task-based functional connectivity (e.g., latent growth, moderation). Second, potential findings can inform the development of more precise treatments and interventions designed to target affective processes, socialization and interpersonal functioning of adolescent girls at risk for psychopathology. Third, assessments of emotional socialization, emotion expression and self-reported interpersonal functioning are completed within each subject, providing an opportunity to test more refined models of how functional connectivity underlying psychological processes may become disrupted and lead to poor interpersonal functioning. Fourth, leveraging existing prospectively collected data provides an unprecedented, and economical, test of individual factors that may moderate brain-behavior associations. This will be one of the most comprehensive and rigorous tests of the associations among early adolescent emotion socialization and emotion expression, trajectories of brain connectivity linked to introspection across adolescence, and interpersonal functioning in young adulthood.

项目概要 人际功能对于一系列心理健康结果至关重要，对于 青春期少女。青春期是促进或阻碍适应性发展的关键时期 由于社会行为的巨大变化和大脑区域的显着成熟而导致的人际功能 促进社会情感处理。尽管如此重要，但很少有前瞻性、纵向研究 使用重复的功能神经影像数据来绘制社交情感大脑连接的轨迹 整个青春期的区域。拟议项目经过严格设计，以使用研究领域标准 （RDoC）社会进程框架，旨在解决社会功能连通性领域的空白 在青春期的几年里，同一女孩在内省时情绪大脑区域会发生变化。 首先，我们将描述 mPFC、楔前叶/后扣带皮层、 以及 16-18 岁的双侧颞中回。然后我们将确定功能连接是否发生变化 从 16 岁到 18 岁会促进还是阻碍女孩在 18 岁时有效的人际交往功能。最后，我们将测试 9-13 岁女孩的情绪表达和情绪社交经历是否会调节 大脑连接轨迹与人际功能之间的关联。我们利用 前所未有的现有神经影像、心理社会功能和社会情感行为数据集 收集了 185 名 9 至 18 岁的女孩，她们是匹兹堡女孩情感研究的一部分。这 项目将研究 RDoC 的多个分析单元（例如电路、范式、行为、自我报告） 对自我和他人的归属感和感知/理解的构建，并将这些分析单元置于 神经发育和环境经历的背景。拟议研究的几个方面将 使我们能够生成极具影响力的数据。首先，样本量将是迄今为止最大的检验样本量之一 基于任务的功能连接轨迹（例如，潜在增长、调节）。其次，潜在的发现可以 为制定针对情感过程的更精确的治疗和干预措施提供信息， 有精神病理学风险的青春期女孩的社会化和人际功能。三、评估 情感社会化、情感表达和自我报告的人际功能是在 每个主题，提供了一个机会来测试更精细的模型，以了解功能连接的底层原理 心理过程可能会受到干扰并导致人际功能不佳。四、借力 现有的前瞻性收集的数据提供了前所未有的、经济的对个体因素的测试， 可能会调节大脑行为关联。这将是最全面、最严格的测试之一 青少年早期情绪社会化和情绪表达、大脑轨迹之间的关联 连接性与青春期的内省以及成年早期的人际功能有关。