Neurophysiological Risk for Adolescent Social Phobia

青少年社交恐惧症的神经生理风险

• 批准号: 8067140
• 负责人: Amanda E Guyer
• 金额: $ 24.17万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8067140
• 关键词: Address; Adolescence; Adolescent; Adult; Anxiety; Anxiety Disorders; Area; Award; Behavior; Behavioral; Behavioral inhibition; Biological; Biology; Brain; Brain region; California; Child; Chronic; Clinical; Collaborations; Corpus striatum structure; Cues; Data; Depression and Suicide; Development; Disease; Disease susceptibility; Early identification; Early treatment; Emotional; Emotions; Evaluation; Event; Extramural Activities; Fellowship; Foxes; Functional disorder; Goals; Grant; Hypersensitivity; Incentives; Institution; Intervention; K-Series Research Career Programs; Life; Link; Maryland; Mediating; Mental Health; Mental disorders; Mentorship; Methodology; Mind; Modeling; National Institute of Mental Health; Nature; Neurophysiology - biologic function; Neurosciences; One-Step dentin bonding system; Pathway interactions; Pattern; Plant Roots; Positioning Attribute; Predisposition; Prevention; Process; Psychiatrist; Psychologist; Psychopathology; Recording of previous events; Relative (related person); Research; Research Personnel; Research Training; Rewards; Risk; Risk Factors; Rodent; Scientist; Social Controls; Social Environment; Social Interaction; Social Phobia; Stimulus; Stress; Temperament; Testing; Therapeutic; Training; United States National Institutes of Health; Universities; Work; affective neuroscience; base; career; career development; childhood anxiety; cohort; design; developmental psychology; disease classification; disorder risk; early childhood; high risk; improved; insight; neuroimaging; neurophysiology; novel; peer; professor; psychobiologic; relating to nervous system; research and development; response; skills; social; social stress; synergism

Anxiety disorders are the most common mental illness among adolescents. Behavioral inhibition (Bl), an early-life predisposition to withdraw from novel, social stimuli, predicts high risk for adolescent anxiety, particularly social phobia (SP). This association persists over decades, yet the neurophysiologicai mechanisms of this association are unclear. The current study examines whether adolescents with SP or a history of temperamental riskfor SP (i.e., Bl) share anomalies in striatal circuitry reflecting hypersensivity to motivationally salient nonsocial and social stimuli. The current aims examine neural response to: (1) nonsocial incentives in adolescents with SP vs. healthy adolescents; (2) social incentives in adolescents with SP vs. healthy adolescents; and (3) social incentives in adolescents with and without temperamental risk for SP. To accomplish these aims, I will use fMRl tasks involving response to (a) anticipated monetary rewards and (b) anticipated peer evaluation. My career goal is to become an independent scientist conducting translationally-oriented work integrating developmental psychology and clinical neuroscience. I have obtained a tenure-track Assistant Professor position at the University of California, Davis (UCD) to begin September 2009.1 am confident that this position, in conjunction with my K99/R00 grant awarded September 2007, will support my goal of becoming an independent researcher whose work focuses on developmental clinical neuroscience. I am seeking to transition this grant from NIMH to the Centerfor Mind and Brain at UCD in accordance with the design ofthe K99/R00 (NIH Pathway to Independence Career Development Award). The intramural component of my grant and accompanying Research Fellowship ends August 2009. The grant is designed for the PI to transition to an extramural institution, i.e. my Assistant Professor position at UCD. I will continue collaboration with NIMH to insure successful completion of my grant, as stipulated in my proposal to achieve my research and career development aims. In particular, I will maintain my strong collaboration with Dr. Daniel Pine (grant sponsor), Chief of the Emotion and Development Branch at NIMH, as well as Dr. Nathan Fox (grant co-sponsor), Distinguished University Professor at U Maryland.

焦虑症是青少年中最常见的精神疾病。行为抑制（BI）， 早期生活倾向于从新奇的社会刺激中退缩，预示着青少年焦虑的高风险， 社交恐惧症（SP）这种联系持续了几十年，但神经生理学 这种关联的机制尚不清楚。目前的研究调查了患有SP或A型糖尿病的青少年， SP的气质风险史（即，Bl）共享纹状体回路异常，反映了对 动机显著的非社会性和社会性刺激。目前的目的是检查神经反应：（1） 非社会性激励在青少年与SP健康青少年;（2）社会性激励在青少年与SP SP与健康青少年;（3）青少年中有和无气质风险的社会激励 SP.为了实现这些目标，我将使用fMRI任务，包括对（a）预期的金钱奖励的反应 和（B）预期的同行评价。我的职业目标是成为一名独立的科学家， 整合发展心理学和临床神经科学的以预防为导向的工作。我有 我在加州大学戴维斯分校（UCD）获得了终身助理教授的职位，开始 2009年9月1日我相信，这个职位，连同我的K99/R 00赠款授予9月 2007年，将支持我成为一名独立研究人员的目标，其工作重点是发展 临床神经科学我正在寻求将这笔赠款从NIMH转移到大脑和大脑中心， UCD符合K99/R 00（NIH独立职业发展途径）的设计 奖）。我的奖学金和伴随的研究奖学金的校内部分将于2009年8月结束。 该补助金是专为PI过渡到校外机构，即我的助理教授职位 在UCD。我将继续与NIMH合作，以确保成功完成我的赠款，如 我的建议，以实现我的研究和职业发展的目标。特别是，我将保持我的坚强 与NIMH情感与发展分支主任丹尼尔派恩博士（赠款赞助商）合作， 以及内森·福克斯博士（资助共同赞助人），马里兰州大学杰出教授。