Neurophysiological Risk for Adolescent Social Phobia

青少年社交恐惧症的神经生理风险

• 批准号: 8067140
• 负责人: Amanda E Guyer
• 金额: $ 24.17万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8067140
• 关键词: Address; Adolescence; Adolescent; Adult; Anxiety; Anxiety Disorders; Area; Award; Behavior; Behavioral; Behavioral inhibition; Biological; Biology; Brain; Brain region; California; Child; Chronic; Clinical; Collaborations; Corpus striatum structure; Cues; Data; Depression and Suicide; Development; Disease; Disease susceptibility; Early identification; Early treatment; Emotional; Emotions; Evaluation; Event; Extramural Activities; Fellowship; Foxes; Functional disorder; Goals; Grant; Hypersensitivity; Incentives; Institution; Intervention; K-Series Research Career Programs; Life; Link; Maryland; Mediating; Mental Health; Mental disorders; Mentorship; Methodology; Mind; Modeling; National Institute of Mental Health; Nature; Neurophysiology - biologic function; Neurosciences; One-Step dentin bonding system; Pathway interactions; Pattern; Plant Roots; Positioning Attribute; Predisposition; Prevention; Process; Psychiatrist; Psychologist; Psychopathology; Recording of previous events; Relative (related person); Research; Research Personnel; Research Training; Rewards; Risk; Risk Factors; Rodent; Scientist; Social Controls; Social Environment; Social Interaction; Social Phobia; Stimulus; Stress; Temperament; Testing; Therapeutic; Training; United States National Institutes of Health; Universities; Work; affective neuroscience; base; career; career development; childhood anxiety; cohort; design; developmental psychology; disease classification; disorder risk; early childhood; high risk; improved; insight; neuroimaging; neurophysiology; novel; peer; professor; psychobiologic; relating to nervous system; research and development; response; skills; social; social stress; synergism

Anxiety disorders are the most common mental illness among adolescents. Behavioral inhibition (Bl), an early-life predisposition to withdraw from novel, social stimuli, predicts high risk for adolescent anxiety, particularly social phobia (SP). This association persists over decades, yet the neurophysiologicai mechanisms of this association are unclear. The current study examines whether adolescents with SP or a history of temperamental riskfor SP (i.e., Bl) share anomalies in striatal circuitry reflecting hypersensivity to motivationally salient nonsocial and social stimuli. The current aims examine neural response to: (1) nonsocial incentives in adolescents with SP vs. healthy adolescents; (2) social incentives in adolescents with SP vs. healthy adolescents; and (3) social incentives in adolescents with and without temperamental risk for SP. To accomplish these aims, I will use fMRl tasks involving response to (a) anticipated monetary rewards and (b) anticipated peer evaluation. My career goal is to become an independent scientist conducting translationally-oriented work integrating developmental psychology and clinical neuroscience. I have obtained a tenure-track Assistant Professor position at the University of California, Davis (UCD) to begin September 2009.1 am confident that this position, in conjunction with my K99/R00 grant awarded September 2007, will support my goal of becoming an independent researcher whose work focuses on developmental clinical neuroscience. I am seeking to transition this grant from NIMH to the Centerfor Mind and Brain at UCD in accordance with the design ofthe K99/R00 (NIH Pathway to Independence Career Development Award). The intramural component of my grant and accompanying Research Fellowship ends August 2009. The grant is designed for the PI to transition to an extramural institution, i.e. my Assistant Professor position at UCD. I will continue collaboration with NIMH to insure successful completion of my grant, as stipulated in my proposal to achieve my research and career development aims. In particular, I will maintain my strong collaboration with Dr. Daniel Pine (grant sponsor), Chief of the Emotion and Development Branch at NIMH, as well as Dr. Nathan Fox (grant co-sponsor), Distinguished University Professor at U Maryland.

焦虑症是青少年中最常见的精神疾病。行为抑制（Bl） 生命早期倾向于回避新奇的社交刺激，预示着青少年焦虑的高风险， 特别是社交恐惧症（SP）。这种关联持续了几十年，但神经生理学 这种关联的机制尚不清楚。目前的研究调查了患有 SP 或其他疾病的青少年是否 SP（即 BL）的气质风险史共享纹状体回路异常，反映对 动机上显着的非社会和社会刺激。目前的目标是检查神经反应：(1) SP 青少年与健康青少年的非社会激励； (2) 青少年的社会激励 SP 与健康青少年； (3) 对有或没有气质风险的青少年的社会激励 SP。为了实现这些目标，我将使用 fMRl 任务，其中涉及对 (a) 预期金钱奖励的响应 (b) 预期的同行评价。我的职业目标是成为一名独立科学家 整合发展心理学和临床神经科学的翻译导向工作。我有 获得加州大学戴维斯分校 (UCD) 终身教授助理教授职位 2009 年 9 月 1 日 我对这个职位以及我于 9 月获得的 K99/R00 补助金充满信心 2007 年，将支持我成为一名独立研究员的目标，其工作重点是发展 临床神经科学。我正在寻求将这笔资金从 NIMH 转移到位于 UCD按照K99/R00（NIH独立职业发展之路）的设计 奖）。我的资助和附带的研究奖学金的校内部分将于 2009 年 8 月结束。 该赠款旨在帮助 PI 过渡到校外机构，即我的助理教授职位 在都柏林大学。我将继续与 NIMH 合作，确保按照 NIMH 的规定成功完成我的资助 我为实现我的研究和职业发展目标而提出的建议。特别是我会保持坚强 与 NIMH 情感与发展部门负责人 Daniel Pine 博士（资助者）合作， 以及马里兰大学杰出大学教授 Nathan Fox 博士（资助共同发起人）。