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Neurophysiological Risk for Adolescent Social Phobia

青少年社交恐惧症的神经生理风险

基本信息

批准号：
8264221
负责人：
Amanda E Guyer
金额：
$ 24.03万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8264221
关键词：
Address Adolescence Adolescent Adult Anxiety Anxiety Disorders Area Award Behavior Behavioral Behavioral inhibition Biological Biology Brain Brain region California Child Chronic Clinical Collaborations Corpus striatum structure Cues Data Depression and Suicide Development Disease Disease susceptibility Early identification Early treatment Emotional Emotions Evaluation Event Extramural Activities Fellowship Foxes Functional disorder Goals Grant Hypersensitivity Incentives Institution Intervention K-Series Research Career Programs Life Link Maryland Mediating Mental Health Mental disorders Mentorship Methodology Mind Modeling National Institute of Mental Health Nature Neurophysiology - biologic function Neurosciences One-Step dentin bonding system Pathway interactions Pattern Plant Roots Positioning Attribute Predisposition Prevention Process Psychiatrist Psychologist Psychopathology Recording of previous events Relative (related person)Research Research Personnel Research Training Rewards Risk Risk Factors Rodent Scientist Social Controls Social Environment Social Interaction Social Phobia Stimulus Stress Temperament Testing Therapeutic Training United States National Institutes of Health Universities Work affective neuroscience base career career development childhood anxiety cohort design developmental psychology disease classification disorder risk early childhood high risk improved insight neuroimaging neurophysiology novel peer professor psychobiologic relating to nervous system research and development response skills social social stress synergism

项目摘要

Anxiety disorders are the most common mental illness among adolescents. Behavioral inhibition (Bl), an early-life predisposition to withdraw from novel, social stimuli, predicts high risk for adolescent anxiety, particularly social phobia (SP). This association persists over decades, yet the neurophysiologicai mechanisms of this association are unclear. The current study examines whether adolescents with SP or a history of temperamental riskfor SP (i.e., Bl) share anomalies in striatal circuitry reflecting hypersensivity to motivationally salient nonsocial and social stimuli. The current aims examine neural response to: (1) nonsocial incentives in adolescents with SP vs. healthy adolescents; (2) social incentives in adolescents with SP vs. healthy adolescents; and (3) social incentives in adolescents with and without temperamental risk for SP. To accomplish these aims, I will use fMRl tasks involving response to (a) anticipated monetary rewards and (b) anticipated peer evaluation. My career goal is to become an independent scientist conducting translationally-oriented work integrating developmental psychology and clinical neuroscience. I have obtained a tenure-track Assistant Professor position at the University of California, Davis (UCD) to begin September 2009.1 am confident that this position, in conjunction with my K99/R00 grant awarded September 2007, will support my goal of becoming an independent researcher whose work focuses on developmental clinical neuroscience. I am seeking to transition this grant from NIMH to the Centerfor Mind and Brain at UCD in accordance with the design ofthe K99/R00 (NIH Pathway to Independence Career Development Award). The intramural component of my grant and accompanying Research Fellowship ends August 2009. The grant is designed for the PI to transition to an extramural institution, i.e. my Assistant Professor position at UCD. I will continue collaboration with NIMH to insure successful completion of my grant, as stipulated in my proposal to achieve my research and career development aims. In particular, I will maintain my strong collaboration with Dr. Daniel Pine (grant sponsor), Chief of the Emotion and Development Branch at NIMH, as well as Dr. Nathan Fox (grant co-sponsor), Distinguished University Professor at U Maryland.

焦虑症是青少年中最常见的精神疾病。行为抑制(Bl)，一个早期倾向于远离新奇的社会刺激，预示着青少年焦虑的高风险，尤其是社交恐惧症。这种关联持续了几十年，但神经生理学这种联系的机制尚不清楚。目前的研究调查了患有SP或A的青少年 SP(即，B1)的气质风险史共享纹状体回路异常，反映对激励性显著的非社会和社会刺激。目前的目标是检查神经反应：(1) SP青少年与健康青少年的非社会激励；(2)SP青少年的社会激励 SP与健康青少年的对比；以及(3)有和没有气质风险的青少年的社会激励。沙棘属(SP.)为了实现这些目标，我将使用fmrl任务，包括响应(A)预期的金钱奖励。和(B)预期的同行评价。我的职业目标是成为一名独立的科学家以翻译为导向，整合发展心理学和临床神经科学。我有过获得加州大学戴维斯分校(UCD)终身教职助理教授职位 2009.1我相信这个职位，加上我在9月授予的K99/R00资助金， 2007年，将支持我成为一名独立研究员的目标，其工作重点是发展临床神经科学。我正在寻求将这笔赠款从NIMH转移到精神和大脑中心，地址是 UCD符合K99/R00(美国国立卫生研究院独立职业发展途径)的设计奖项)。我的助学金和随行的研究奖学金的内部部分将于2009年8月结束。这笔补助金是为了让PI过渡到校外机构，即我的助理教授职位在UCD。我将继续与NIMH合作，确保成功完成我的赠款，如我的建议是为了实现我的研究和职业发展目标。特别是，我将保持我的坚强与NIMH情感与发展科主任Daniel Pine博士(赠款赞助商)合作，以及内森·福克斯博士(赠款共同赞助人)，他是马里兰大学杰出的大学教授。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Striatal functional alteration during incentive anticipation in pediatric anxiety disorders.

小儿焦虑症激励预期期间纹状体功能的改变。

DOI：
10.1176/appi.ajp.2011.11010006
发表时间：
2012-02
期刊：
The American journal of psychiatry
影响因子：
0
作者：
Guyer AE;Choate VR;Detloff A;Benson B;Nelson EE;Perez-Edgar K;Fox NA;Pine DS;Ernst M
通讯作者：
Ernst M

Social re-orientation and brain development: An expanded and updated view.