权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neurophysiological Risk for Adolescent Social Phobia

青少年社交恐惧症的神经生理风险

基本信息

批准号：
8016840
负责人：
Amanda E Guyer
金额：
$ 24.9万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8016840
关键词：
Address Adolescence Adolescent Adult Anxiety Anxiety Disorders Area Award Behavior Behavioral Behavioral inhibition Biological Biology Brain Brain region California Child Chronic Clinical Collaborations Corpus striatum structure Cues Data Depression and Suicide Development Disease Disease susceptibility Early identification Early treatment Emotional Emotions Evaluation Event Extramural Activities Fellowship Foxes Functional disorder Goals Grant Hypersensitivity Incentives Institution Intervention K-Series Research Career Programs Life Link Maryland Mediating Mental Health Mental disorders Mentorship Methodology Mind Modeling National Institute of Mental Health Nature Neurophysiology - biologic function Neurosciences One-Step dentin bonding system Pathway interactions Pattern Plant Roots Positioning Attribute Predisposition Prevention Process Psychiatrist Psychologist Psychopathology Recording of previous events Relative (related person)Research Research Personnel Research Training Rewards Risk Risk Factors Rodent Scientist Social Environment Social Interaction Social Phobia Stimulus Stress Temperament Testing Therapeutic Training United States National Institutes of Health Universities Work affective neuroscience base career career development childhood anxiety cohort design developmental psychology disease classification disorder risk early childhood high risk improved insight neuroimaging neurophysiology novel peer professor psychobiologic relating to nervous system response skills social social stress synergism

项目摘要

Anxiety disorders are the most common mental illness among adolescents. Behavioral inhibition (Bl), an early-life predisposition to withdraw from novel, social stimuli, predicts high risk for adolescent anxiety, particularly social phobia (SP). This association persists over decades, yet the neurophysiologicai mechanisms of this association are unclear. The current study examines whether adolescents with SP or a history of temperamental riskfor SP (i.e., Bl) share anomalies in striatal circuitry reflecting hypersensivity to motivationally salient nonsocial and social stimuli. The current aims examine neural response to: (1) nonsocial incentives in adolescents with SP vs. healthy adolescents; (2) social incentives in adolescents with SP vs. healthy adolescents; and (3) social incentives in adolescents with and without temperamental risk for SP. To accomplish these aims, I will use fMRl tasks involving response to (a) anticipated monetary rewards and (b) anticipated peer evaluation. My career goal is to become an independent scientist conducting translationally-oriented work integrating developmental psychology and clinical neuroscience. I have obtained a tenure-track Assistant Professor position at the University of California, Davis (UCD) to begin September 2009.1 am confident that this position, in conjunction with my K99/R00 grant awarded September 2007, will support my goal of becoming an independent researcher whose work focuses on developmental clinical neuroscience. I am seeking to transition this grant from NIMH to the Centerfor Mind and Brain at UCD in accordance with the design ofthe K99/R00 (NIH Pathway to Independence Career Development Award). The intramural component of my grant and accompanying Research Fellowship ends August 2009. The grant is designed for the PI to transition to an extramural institution, i.e. my Assistant Professor position at UCD. I will continue collaboration with NIMH to insure successful completion of my grant, as stipulated in my proposal to achieve my research and career development aims. In particular, I will maintain my strong collaboration with Dr. Daniel Pine (grant sponsor), Chief of the Emotion and Development Branch at NIMH, as well as Dr. Nathan Fox (grant co-sponsor), Distinguished University Professor at U Maryland.

焦虑症是青少年中最常见的精神疾病。行为抑制（Bl）