Phenix: Integrated algorithms for high quality models from crystallographic and cryo-EM data

Phenix:基于晶体学和冷冻电镜数据的高质量模型的集成算法

基本信息

项目摘要

Overall Summary/Abstract The Phenix software has been developed as a result of the highly collaborative work of 4 groups located at Lawrence Berkeley Laboratory, Los Alamos National Laboratory, Cambridge University, and Duke University. Building on our prior work we will continue to collaborate in the development of new methods to improve structure solution, with a focus on low (near atomic) resolution (3-4.5Å). Researchers still encounter significant problems in solving and completing structures in this regime. Improvements in single wavelength anomalous (SAD) phasing, molecular replacement, model building, refinement and validation will make it possible for researchers to tackle more challenging experimental systems. This is particularly timely as new approaches to data collection, such as serial crystallography, are producing lower resolution structures of membrane proteins and large flexible complexes. Recent developments in the field of single particle cryo-electron microscopy (cryo-EM) have generated a rapid growth in the number of large macromolecular complexes solved ab initio. Therefore, a significant area of development for the Phenix team in the next 5 years will be cryo-EM, in particular near atomic resolution single particle image reconstruction. This is one of the most exciting developments in the field of structural biology in recent history. Our goal will be to collaborate to extend our current methods, and develop new ones, to address the problems of model fitting, model building, refinement and validation of atomic models derived from cryo-EM maps.
整体总结/文摘

项目成果

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PAUL David ADAMS其他文献

PAUL David ADAMS的其他文献

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{{ truncateString('PAUL David ADAMS', 18)}}的其他基金

EIGER2 S 16M Detector
EIGER2 S 16M 探测器
  • 批准号:
    10415587
  • 财政年份:
    2022
  • 资助金额:
    $ 184.21万
  • 项目类别:
Phenix: providing high quality software to the research community for crystallography and cryo-EM
Phenix:为晶体学和冷冻电镜研究界提供高质量软件
  • 批准号:
    10400939
  • 财政年份:
    2021
  • 资助金额:
    $ 184.21万
  • 项目类别:
Phenix: providing high quality software to the research community for crystallography and cryo-EM
Phenix:为晶体学和冷冻电镜研究界提供高质量软件
  • 批准号:
    10633077
  • 财政年份:
    2021
  • 资助金额:
    $ 184.21万
  • 项目类别:
Phenix: providing high quality software to the research community for crystallography and cryo-EM
Phenix:为晶体学和冷冻电镜研究界提供高质量软件
  • 批准号:
    10194082
  • 财政年份:
    2021
  • 资助金额:
    $ 184.21万
  • 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
  • 批准号:
    9370112
  • 财政年份:
    2017
  • 资助金额:
    $ 184.21万
  • 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
  • 批准号:
    10901666
  • 财政年份:
    2017
  • 资助金额:
    $ 184.21万
  • 项目类别:
Administration Core
行政核心
  • 批准号:
    10201647
  • 财政年份:
    2017
  • 资助金额:
    $ 184.21万
  • 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
  • 批准号:
    10201646
  • 财政年份:
    2017
  • 资助金额:
    $ 184.21万
  • 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
  • 批准号:
    10798865
  • 财政年份:
    2017
  • 资助金额:
    $ 184.21万
  • 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
  • 批准号:
    10399882
  • 财政年份:
    2017
  • 资助金额:
    $ 184.21万
  • 项目类别:

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