Phenix: Integrated algorithms for high quality models from crystallographic and cryo-EM data
Phenix:基于晶体学和冷冻电镜数据的高质量模型的集成算法
基本信息
- 批准号:9209981
- 负责人:
- 金额:$ 184.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAlgorithmsAreaBackBayesian MethodBiologicalCollaborationsComplexComputer softwareCryoelectron MicroscopyCrystallographyDataData CollectionDepositionDevelopmentElectron MicroscopyEnvironmentEvolutionFosteringGeometryGoalsHealthHomology ModelingHumanLaboratoriesLifeLikelihood FunctionsMacromolecular ComplexesManualsMapsMembraneMethodsModelingModernizationMolecularMolecular ConformationPharmaceutical PreparationsPhasePhilosophyProbabilityProcessRecording of previous eventsResearchResearch InfrastructureResearch PersonnelResolutionRewardsRouteStructureSystemTimeUniversitiesValidationWashingtonWorkX-Ray Crystallographybasebiological systemscollaborative approachdensityflexibilityhuman diseaseimage reconstructionimprovedmodel buildingmolecular dynamicsnovel strategiesnovel therapeuticsparticleprogramsprotein structurerapid growthreconstructionsoftware developmentstructural biologysuccesstool
项目摘要
Overall Summary/Abstract
The Phenix software has been developed as a result of the highly collaborative work of 4 groups
located at Lawrence Berkeley Laboratory, Los Alamos National Laboratory, Cambridge University, and
Duke University. Building on our prior work we will continue to collaborate in the development of new
methods to improve structure solution, with a focus on low (near atomic) resolution (3-4.5Å).
Researchers still encounter significant problems in solving and completing structures in this regime.
Improvements in single wavelength anomalous (SAD) phasing, molecular replacement, model building,
refinement and validation will make it possible for researchers to tackle more challenging experimental
systems. This is particularly timely as new approaches to data collection, such as serial crystallography,
are producing lower resolution structures of membrane proteins and large flexible complexes.
Recent developments in the field of single particle cryo-electron microscopy (cryo-EM) have generated
a rapid growth in the number of large macromolecular complexes solved ab initio. Therefore, a
significant area of development for the Phenix team in the next 5 years will be cryo-EM, in particular
near atomic resolution single particle image reconstruction. This is one of the most exciting
developments in the field of structural biology in recent history. Our goal will be to collaborate to extend
our current methods, and develop new ones, to address the problems of model fitting, model building,
refinement and validation of atomic models derived from cryo-EM maps.
整体总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PAUL David ADAMS其他文献
PAUL David ADAMS的其他文献
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{{ truncateString('PAUL David ADAMS', 18)}}的其他基金
Phenix: providing high quality software to the research community for crystallography and cryo-EM
Phenix:为晶体学和冷冻电镜研究界提供高质量软件
- 批准号:
10400939 - 财政年份:2021
- 资助金额:
$ 184.21万 - 项目类别:
Phenix: providing high quality software to the research community for crystallography and cryo-EM
Phenix:为晶体学和冷冻电镜研究界提供高质量软件
- 批准号:
10633077 - 财政年份:2021
- 资助金额:
$ 184.21万 - 项目类别:
Phenix: providing high quality software to the research community for crystallography and cryo-EM
Phenix:为晶体学和冷冻电镜研究界提供高质量软件
- 批准号:
10194082 - 财政年份:2021
- 资助金额:
$ 184.21万 - 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
- 批准号:
9370112 - 财政年份:2017
- 资助金额:
$ 184.21万 - 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
- 批准号:
10901666 - 财政年份:2017
- 资助金额:
$ 184.21万 - 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
- 批准号:
10201646 - 财政年份:2017
- 资助金额:
$ 184.21万 - 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
- 批准号:
10798865 - 财政年份:2017
- 资助金额:
$ 184.21万 - 项目类别:
ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)
ALS 高效联网高级光束线实验 (ALS-ENABLE)
- 批准号:
10399882 - 财政年份:2017
- 资助金额:
$ 184.21万 - 项目类别:
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