VGM: Vanderbilt Genomic Medicine Training Program

 描述(由申请者提供)：本申请寻求支持在范德比尔特大学医学中心(VUMC)开发一个新的博士后培训计划，“VGM：Vanderbilt基因组医学培训计划”。VUMC拥有许多国家认可的基因组医学资源，这一倡议为VUMC提供了一个及时的机会，以扩大当前在新兴基因组医学领域的努力，同时使这一新计划与NHGRI修订后的战略计划(NOT-HG-14-017)保持一致。VGM将包括药物基因组学、精确表型、医学信息学和基于疾病的基因组学的主要重点。该计划基于数十年来在关键支持资源方面的优势，例如1)BioVU，将DNA样本与单一学术机构的电子病历(EMR)链接的最大生物库(现在&GT；204,000名受试者)，2)参与NHGRI资助的三个网络：电子医疗记录和基因组学(Emerge)网络和Emerge协调中心，实践中实施基因组学(IGITE)网络，以及未诊断疾病网络(UDN)，3)在患者EMR中嵌入遗传信息以指导药物和剂量选择的药物基因组资源增强护理和治疗决策(Forect)项目(作为正在进行的Emerge-PGx项目的一个模型，该项目在Emerge中实施类似的先发制人的基因分型范例)，4)癌症个性化治疗计划，其应用肿瘤基因组测序来识别癌症中的可操作突变和个性化靶向治疗，5)艾滋病毒-药物基因组学计划，6)全国最大的生物医学信息学系，拥有强大的临床信息技术研究、教育和支持计划，以及7)参与和领导NIH的其他相关工作，包括基因型-组织表达项目(GTEx)和药物基因组学研究网络(PGRN)。该计划有29名高度合作和资金充足的教员导师，他们合作为博士和医学博士级别的博士后研究员提供基础和临床研究培训机会。实习生将参加轮换、实习、研讨会、杂志俱乐部和静修活动，并与其他实习生和教职员工互动。在Vanderbilt生物医学研究教育和培训(BRET)办公室下，该计划将提供RCR培训、高标准个人发展计划(IDP)和职业发展计划，从而促进学员成为基因组医学的下一代领导者。将成立一个科学咨询委员会和一个外部咨询委员会，就VGM计划的发展和加强提供宝贵的建议。该计划将积极寻求支持那些来自少数群体的人。我们的基本模式是通过在先前培训的基础上为每个受训者量身定做课程来加强多学科培训，再加上独特的“结对指导”方法，在这种方法中，每个受训者将有两名导师，一名负责临床研究，一名负责基础研究。解决问题的团队科学方法是VGM项目的基础。

 DESCRIPTION (provided by applicant): This application seeks support to develop a new postdoctoral training program, "VGM: Vanderbilt Genomic Medicine Training Program," at Vanderbilt University Medical Center (VUMC). VUMC houses a number of nationally recognized resources for genomic medicine, and this initiative represents a timely opportunity for VUMC to expand current efforts in the emerging field of genomic medicine while aligning this new program with the revised strategic plan of the NHGRI (NOT-HG-14-017). VGM will include a major focus in pharmacogenomics, precision phenotyping, medical informatics, and disease-based genomics. The program builds on decades-long strengths in critical enabling resources such as 1) BioVU, the largest biobank linking DNA samples to electronic medical records (EMRs) at a single academic institution (now >204,000 subjects), 2) Participation in three NHGRI-funded networks: the Electronic Medical Records and Genomics (eMERGE) network and eMERGE coordinating center, the Implementing Genomics in Practice (IGNITE) Network, and the Undiagnosed Disease Network (UDN), 3) The Pharmacogenomic Resource for Enhanced Decisions In Care and Treatment (PREDICT) project that embeds genetic information in patient EMRs to guide drug and dosage choices (PREDICT served as one model for the ongoing eMERGE-PGx project that implements a similar preemptive genotyping paradigm across eMERGE), 4) the Program in Personalized Therapy for Cancer that applies tumor genome sequencing to identify actionable mutations in cancers and to personalized target therapy, 5) The HIV-Pharmacogenomics program, 6) the largest Department of Biomedical Informatics in the country, with strong research, education, and support programs in clinical information technology, and 7) participation and leadership in other related efforts at NIH, including the Genotype-Tissue Expression project (GTEx) and the Pharmacogenomics Research Network (PGRN). The program has 29 highly collaborative and well-funded faculty preceptors who team up to provide both basic and clinical research training opportunities to both Ph.D.-level and M.D.-level postdoctoral fellows. Trainees will participate in rotations, internship, seminars, journal clubs, and retreats and interact with other trainees and faculty. Under Vanderbilt's Biomedical Research Education and Training (BRET) Office, the program will provide RCR training, high- standard Individual Development Plans (IDP), and the Career Development programs, thus promoting trainees to be next-generation leaders in genomic medicine. A Scientific Advisory Committee and an External Advisory Committee will be formed to provide valuable advice on VGM program development and enhancement. The program will actively seek to support those from minority groups. Our fundamental model is to enhance multidisciplinary training through a curriculum tailored for each trainee based on prior training, coupled to a unique "paired-mentoring" approach in which each trainee will have two preceptors, one in clinical research and one in basic research. A team science approach to problem solving is fundamental in VGM program.