Training Program in Cancer Biology

癌症生物学培训计划

• 批准号: 9312767
• 负责人: Scott D Cramer
• 金额: $ 37.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-07 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9312767
• 关键词: Cancer Biology; Training Programs

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis, and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis, and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz including world renown research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast, prostate and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. The Co-PIs of this training program have leadership roles within the institution that integrate the University of Colorado Cancer Center and the Graduate School into this training program. Dr. Cramer is co-director of the Hormone-Related Malignancies group within the Cancer Center and works with other Cancer Center leadership to establish goals and directions of the cancer center. Dr. Reyland is director of the Cancer Biology pre-doctoral training program, providing a strong link to the Graduate School. Additional integration comes from other training faculty who are all members of the Cancer Center (many with leadership roles), and several also have leadership roles in the Graduate School. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre-doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhDs. The total of 31 training faculty were selected based on their scientific expertise and track record of mentorship. Based on the NCIs postdoctoral/predoctoral training ratio of 3:1, this application proposes to appoint 3 new postdocs and 1 new predoctoral student in year 1, and 6 post-docs and 2 pre-doctoral students per award year for years 2-5. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.

抽象的 尽管在过去的几年中，我们对细胞和分子的基本理解有了重大突破 导致癌症的变化，癌变的许多关键步骤以及促进早期癌症的变化 入侵和转移，仍然定义很差。严格培训未来的癌症年轻调查员 生物学对于我们寻求更深入的癌变和发展至关重要 更好的早期癌症检测方法，改善诊断和有效的新癌症治疗方法。这 癌症生物学培训计划（TPCB）是所有癌症亚型的多学科计划 利用Cu Anschutz的独特优势和培训机会，包括世界著名研究 在功能基因组学，实验治疗，类固醇受体信号，干细胞和器官特异性 癌症（尤其是肺，乳房，前列腺和血液）。我们的目标是在 癌症研究的尖端，以最好地准备我们的学员在生物医学研究环境中竞争 越来越多地专注于基础研究的翻译应用。我们的培训计划包括实验室 培训，教学活动，参加科学会议，专业发展和职业 指导，沟通技巧的发展以及接触临床观点。这个的co 培训计划在整合科罗拉多大学癌症的机构中担任领导职务 中心和研究生院进入该培训计划。 Cramer博士是激素相关的联合导演 癌症中心内的恶性肿瘤小组，并与其他癌症中心领导层合作建立目标 和癌症中心的方向。雷兰德博士是癌症生物学前培训计划的主任， 与研究生院提供了牢固的联系。额外的整合来自其他培训教师 癌症中心的所有成员（许多扮演领导角色），其中一些人在 研究所。癌症中心，研究生院和各个部门的资源是 致力于支持培训计划。癌症中心的基础设施尤为重要，因为 它为培训教师提供可用的核心资源，因此可以为受训者提供。这 拟议的计划将包括通过癌症生物学研究生培训计划的博士前培训， 该博士学位居住在研究生院和博士学位后培训。总共31位培训教师 根据他们的科学专业知识和指导记录选择。基于NCI 博士后/博士后训练率为3：1，本申请提议任命3个新的博士后和1个新的 第1年的专业学生，在2 - 5年的每年奖励年度学生和2名博士后学生。我们 将根据其研究和学术记录从外部和内部池中选择受训者，以及 对癌症研究的承诺。我们致力于在各个层面提供全面的培训，以便 最好为学员在学术界或外部的生物医学科学领域的成功职业做好准备。