Vascular Biology and Human Disease: From Molecular Pathways to Novel Therapies

摘要 请求为题为血管生物学和人类疾病的Keystone研讨会提供支持： 从分子途径到新疗法，由Elisabetta Dejana博士、Anne C.Eichmann博士和 加文·O·瑟斯顿。大会将于2018年2月25日至3月1日在新墨西哥州圣达菲举行。 近年来，我们对胚胎期间维管系统如何形成的认识有了很大的进步。 在癌症等增殖性疾病中表达的成人。它已经变得毫不含糊 显然，血管内皮细胞在动脉、静脉和淋巴管中表达高度特异和独特的功能。 此外，内皮细胞能够进一步修改其功能属性，以满足特定的 不同器官的需要。本次会议将讨论协调特定器官的机制 内皮分化，在内皮功能障碍和器官病理之间建立了联系。这个 主要的挑战将是将我们的实验知识与对人类血管疾病的理解联系起来。 研讨会将汇集血管生物学家、神经学家、免疫学家和临床医生组成的团队。 来自世界各地的人分享他们的最新发现，并指导未来的努力，寻找新的和更多的 精确的治疗方法。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Vascular Biology and Human Diseases: From Molecular Pathways to Novel Therapeutics, organized by Drs. Elisabetta Dejana, Anne C. Eichmann and Gavin O. Thurston. The conference will be held in Santa Fe, New Mexico from February 25 – March 1, 2018. Recent years have seen rapid progress in our knowledge of how the vascular system is formed during embryo development and in adults expressing in proliferative diseases such as cancer. It has become unequivocally evident that endothelial cells express highly specific and distinct functions in arteries, veins and lymphatics. Moreover, endothelial cells are able to further modify their functional properties in order to meet the specific needs of the different organs. This meeting will address the mechanisms that orchestrate organ-specific endothelial differentiation, making a connection between endothelial dysfunction and organ pathology. The major challenge will be to link our experimental knowledge to the understanding of human vascular diseases. The symposium will bring together teams of vascular biologists, neuroscientists, immunologists and clinicians from all over the world to share their recent discoveries and to direct future efforts to find novel and more precise therapies.