Longevity and Stress in African American Families

非裔美国家庭的长寿和压力

基本信息

批准号：
9516848
负责人：
ROLAND J. THORPE
金额：
$ 70.57万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9516848
关键词：
Address Adult Affect African American Age Behavioral Biological Candidate Disease Gene Child Complex Data Disadvantaged Discrimination Elderly Environment Environmental Risk Factor Ethnic group Family Generations Genes Genetic Genetic Predisposition to Disease Goals Health Health Status Healthcare Systems Heritability Knowledge Lead Life Expectancy Longevity Methods Molecular Genetics Morbidity - disease rate National Institute on Aging Neighborhoods Outcome Parents Pattern Perception Personality Physiological Play Population Psychosocial Factor Quantitative Genetics Race Research Risk Role Sampling Scientist Siblings Stress Stress and Coping Survivors Time Woman Work biobehavior coping design effective intervention gene environment interaction genetic approach health care availability health disparity healthy aging innovation longevity gene men mortality novel psychologic racial discrimination social survivorship

项目摘要

Project Summary/Abstract The goal of this application is to identify patterns of perceived stress, active coping style, health status and genes that contribute to longevity observed within African American families. We will examine these factors using vertical and horizontal approaches by studying similarities between siblings and parent-child pairs. To this end, we have the following questions: 1) Do familial effects (genes and shared environments) create similarity in the patterns of perceived tress and coping within and across generations? 2) Does stress account for differences in patterns of longevity between families? 3) Do psychosocial factors like stress, coping, and discrimination account for differences in patterns of health status and longevity between families? 4) What role do genes play in patterns of stress and longevity? 5) Are there gene-environment interactions between genes associated with stress and longevity and environmental factors such as family financial adversity and discrimination? To address these research questions, we have planned five specific aims: 1) Collect data from 750 older African Americans on perceptions of stress, discrimination, coping style, health, personality and genetics from multi-generation families (parent-child and siblings). 2) Examine similarities and differences in stress and coping, and health status among sibling pairs and across generations within families. 3) Compare the health status of siblings concordant for higher stress and poorer coping to those with lower stress and better coping. 4) Examine genes associated with stress and longevity in comparisons of long lived families and short lived families and among sibling pairs. 5) Are there gene-environment interactions between genes associated with stress and longevity and environmental factors such as family financial adversity and discrimination? This project is novel and innovative in that it will employ a multi method approach to understand longevity. It will use a quantitative genetic approach, a molecular genetic approach, and a multi generation approach. To our knowledge, this is the first time all of these methods have been employed on one sample.

项目摘要/摘要该应用程序的目的是确定感知到的压力，主动应对方式的模式，健康状况和基因有助于在非洲裔美国家庭中观察到的长寿。我们将通过研究相似性来使用垂直和水平方法检查这些因素在兄弟姐妹和亲子对之间。为此，我们有以下问题： 1）做家族效应（基因和共享环境）在模式的模式中创造了相似之处在几代人的内外感知到的Tress和应对？ 2）压力是否会说明家庭之间寿命寿命模式的差异？ 3）在压力，应对和歧视之类的社会心理因素上说明了差异家庭之间健康状况和寿命的模式？ 4）基因在压力和寿命模式中起什么作用？ 5）是否存在与应激相关的基因之间的基因环境相互作用寿命和环境因素，例如家庭财务逆境和歧视？为了解决这些研究问题，我们计划了五个具体目标： 1）从750名非洲裔美国人那里收集有关压力，歧视的感知，应对多代家庭的应对风格，健康，个性和遗传学（亲子和兄弟姐妹）。 2）检查压力和应对的相似性和差异以及兄弟姐妹的健康状况对家庭内部和跨几代人的成对。 3）比较兄弟姐妹的健康状况一致，以增加压力和较差的应对压力较低且应对更好的人。 4）检查长期生活家族的比较中与压力和寿命相关的基因和短暂的家庭以及兄弟姐妹对。 5）是否存在与应激相关的基因之间的基因环境相互作用寿命和环境因素，例如家庭财务逆境和歧视？该项目是新颖和创新的，因为它将采用多种方法了解寿命。它将使用定量遗传方法，一种分子遗传方法和多代方法。据我们所知，这是所有这些方法已在一个样本上使用。