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Longevity and Stress in African American Families

非裔美国家庭的长寿和压力

基本信息

批准号：
9977070
负责人：
ROLAND J. THORPE
金额：
$ 7.69万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2020-08-21
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9977070
关键词：
Address Adult Affect African American Age Behavioral Biological Candidate Disease Gene Child Complex Data Disadvantaged Discrimination Elderly Environment Environmental Risk Factor Ethnic group Family Generations Genes Genetic Genetic Predisposition to Disease Goals Health Health Status Healthcare Systems Heritability Knowledge Lead Life Expectancy Longevity Methods Molecular Genetics Morbidity - disease rate National Institute on Aging Neighborhoods Outcome Parents Pattern Perception Personality Physiological Play Population Psychosocial Factor Quantitative Genetics Race Research Risk Role Sampling Scientist Siblings Stress Stress and Coping Survivors Time Woman Work biobehavior coping design effective intervention gene environment interaction genetic approach health care availability health disparity healthy aging innovation longevity gene men mortality mortality risk novel perceived stress psychologic racial discrimination social social culture social disadvantage survivorship

项目摘要

Project Summary/Abstract The goal of this application is to identify patterns of perceived stress, active coping style, health status and genes that contribute to longevity observed within African American families. We will examine these factors using vertical and horizontal approaches by studying similarities between siblings and parent-child pairs. To this end, we have the following questions: 1) Do familial effects (genes and shared environments) create similarity in the patterns of perceived tress and coping within and across generations? 2) Does stress account for differences in patterns of longevity between families? 3) Do psychosocial factors like stress, coping, and discrimination account for differences in patterns of health status and longevity between families? 4) What role do genes play in patterns of stress and longevity? 5) Are there gene-environment interactions between genes associated with stress and longevity and environmental factors such as family financial adversity and discrimination? To address these research questions, we have planned five specific aims: 1) Collect data from 750 older African Americans on perceptions of stress, discrimination, coping style, health, personality and genetics from multi-generation families (parent-child and siblings). 2) Examine similarities and differences in stress and coping, and health status among sibling pairs and across generations within families. 3) Compare the health status of siblings concordant for higher stress and poorer coping to those with lower stress and better coping. 4) Examine genes associated with stress and longevity in comparisons of long lived families and short lived families and among sibling pairs. 5) Are there gene-environment interactions between genes associated with stress and longevity and environmental factors such as family financial adversity and discrimination? This project is novel and innovative in that it will employ a multi method approach to understand longevity. It will use a quantitative genetic approach, a molecular genetic approach, and a multi generation approach. To our knowledge, this is the first time all of these methods have been employed on one sample.

项目摘要/摘要该应用程序的目标是识别感知到的压力、积极的应对方式、在非裔美国人家庭中观察到的健康状况和有助于长寿的基因。我们将通过研究相似性，使用纵向和横向方法来检验这些因素兄弟姐妹和亲子之间的关系。为此，我们有以下问题： 1)家族性影响(基因和共享环境)是否会在在世代内部和世代之间感受到的压力和应对方式？ 2)压力是否能解释家庭间寿命模式的差异？ 3)心理社会因素，如压力、应对和歧视，是否解释了家庭之间的健康状况和寿命模式？ 4)基因在压力和寿命模式中扮演什么角色？ 5)应激相关基因与环境之间是否存在基因-环境互作长寿和环境因素，如家庭经济困难和歧视？为了解决这些研究问题，我们计划了五个具体目标： 1)收集750名年长的非裔美国人关于压力、歧视、来自多代家庭的应对方式、健康、个性和遗传学(亲子和兄弟姐妹)。 2)检查兄弟姐妹在压力和应对方式以及健康状况方面的异同成双成对，并在家庭内跨越几代人。 3)比较压力较大和应对能力较差的兄弟姐妹的健康状况那些压力较小、应对能力较好的人。 4)在长寿家庭的比较中检查与压力和长寿相关的基因以及短命的家庭和兄弟姐妹之间。 5)应激相关基因与环境之间是否存在基因-环境互作长寿和环境因素，如家庭经济困难和歧视？这个项目是新颖和创新的，因为它将采用多种方法来了解长寿。它将使用数量遗传学方法，一种分子遗传学方法和多代方法。据我们所知，这是第一次所有这些方法已经在一个样本上使用。