Social Isolation, Loneliness and Dementia Among Middle and Old Age Black Men

中老年黑人的社会孤立、孤独和痴呆症

• 批准号: 10285198
• 负责人: ROLAND J. THORPE
• 金额: $ 8.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285198
• 关键词: Address; Administrative Supplement; Adult; Affect; African American; Age; Aging; Alzheimer' s disease related dementia; Area; Award; Beech; Behavioral; Biological; Biological Markers; Cause of Death; Cessation of life; Chronic Disease; Data; Data Set; Dementia; Development; Disease; Economics; Environment; Exposure to; Extroversion; Family; Foundations; Functional disorder; Gap Junctions; Gender; Genes; Genetic; Goals; Health; Health and Retirement Study; Impaired cognition; Independent Scientist Award; Knowledge; Lead; Life; Life Cycle Stages; Link; Loneliness; Longevity; Maintenance; Mentors; Modeling; Neighborhoods; Neurotic Disorders; Onset of illness; Outcome; Personality Traits; Physiological; Population; Positioning Attribute; Premature Mortality; Psychological Stress; Publishing; Race; Reproduction; Research; Resources; Risk; Role; Scientist; Social Behavior; Social Interaction; Social Network; Social isolation; Stress; Structure; System; Time; Underrepresented Minority; United States; Work; behavioral economics; biopsychosocial; black men; career; coping; early onset; economic determinant; experience; healthy aging; human old age (65+); in utero; male health; men; middle age; minority investigator; mortality; novel; parent grant; peer; premature; programs; protective factors; psychologic; psychosocial; response; social; social factors; social relationships; social stress; stressor; systemic inflammatory response; theories

ABSTRACT Alzheimer’s disease and related dementias (ADRD) is prevalent in approximately 6 million people and is the 6th leading cause of death among adults in the United States. The burden of ADRD is not equally distributed across populations as rates among Blacks are two to three times greater than their White peers. Black males are disproportionately represented among those with ADRD, however, they few studies have exclusively focused on this population. The maintenance of accessible and supportive social networks during middle and older ages are influenced by personality trait and has been shown to be a protective factor for cognitive decline and onset of ADRD. The Caciappo Evolutionary Theory of Loneliness posits that beneficial social interactions and reliable social relationships can contribute to the longevity of life, reproduction and genetic legacy. This theory leverages the work of Weiss that conceptualizes loneliness as perceived isolation that is a “gnawing, chronic disease without redeeming features”. This project seeks to examine how personality trait, social isolation and loneliness impact dementia onset among middle to older age Black males. The aims for the proposed supplement are to: 1) Investigate the independent association of social isolation and loneliness on dementia among middle and old age Black men; and 2) Examine the impact of the 5-factor model personality traits (e.g. extroversion, neuroticism, agreeableness, openness and conscientiousness) on the associations between social isolation, loneliness and dementia among middle and old age Black men.

抽象的 阿尔茨海默氏病和相关痴呆症（ADRD）在大约600万中普遍存在 人，是美国成年人中第六大死亡原因。燃烧的 ADRD并非在人群中平均分布，因为黑人的价格为两到三 比白人同龄人大的时候。黑人男性在 但是，那些有ADRD的人很少研究仅专注于这一人群。这 在中年和年龄较大的年龄段维护可访问和支持的社交网络是 受人格特征的影响，已被证明是认知下降的受保护因素 和Adrd的发作。 Caciappo的孤独进化论认为这是有益的 社会互动和可靠的社会关系可以促进生活的寿命， 繁殖和遗传遗产。该理论利用魏斯的工作概念化 孤独感是一种“无赎回的慢性疾病”的孤立 特征”。该项目试图研究人格特质，社会隔离和孤独感如何 撞击中年至老年男性的痴呆症发作。提议的目的 补充是：1）调查社会隔离和孤独的独立关联 关于中年和老年黑人的痴呆症； 2）检查5因子的影响 模型人格特征（例如外向，神经质，愉快，开放性和 认真对社会隔离，孤独与痴呆之间的关联 在中年和老年黑人中。