Social Isolation, Loneliness and Dementia Among Middle and Old Age Black Men

摘要 阿尔茨海默病和相关痴呆症（ADRD）在大约600万人中流行， 是美国成年人死亡的第六大原因。的负担 ADRD在人群中的分布并不均匀，因为黑人的发病率为2至3 比他们的白色同龄人高出一倍。黑人男性在以下人群中所占比例过高： 然而，对于那些患有ADRD的人，很少有研究专门关注这一人群。的 在中年和老年期间维持可利用和支持性的社交网络， 受人格特质的影响，并已被证明是认知能力下降的保护因素 和ADRD的发病。Caciappo进化论认为， 社会交往和可靠的社会关系有助于长寿， 生殖和遗传遗产。这个理论利用了韦斯的工作， 孤独是一种“折磨人的慢性病，没有救赎”， 特色”。这个项目旨在研究人格特质、社会孤立和孤独 影响中老年黑人男性痴呆症发病。建议的目标 补充如下：1）调查社会隔离与孤独的独立关联 对中年和老年黑人男性痴呆症的影响; 2）检查5个因素的影响 模范人格特质（如外向、神经质、宜人、开放和 社交孤立、孤独和痴呆之间的关系 中年和老年黑人。

ABSTRACT Alzheimer’s disease and related dementias (ADRD) is prevalent in approximately 6 million people and is the 6th leading cause of death among adults in the United States. The burden of ADRD is not equally distributed across populations as rates among Blacks are two to three times greater than their White peers. Black males are disproportionately represented among those with ADRD, however, they few studies have exclusively focused on this population. The maintenance of accessible and supportive social networks during middle and older ages are influenced by personality trait and has been shown to be a protective factor for cognitive decline and onset of ADRD. The Caciappo Evolutionary Theory of Loneliness posits that beneficial social interactions and reliable social relationships can contribute to the longevity of life, reproduction and genetic legacy. This theory leverages the work of Weiss that conceptualizes loneliness as perceived isolation that is a “gnawing, chronic disease without redeeming features”. This project seeks to examine how personality trait, social isolation and loneliness impact dementia onset among middle to older age Black males. The aims for the proposed supplement are to: 1) Investigate the independent association of social isolation and loneliness on dementia among middle and old age Black men; and 2) Examine the impact of the 5-factor model personality traits (e.g. extroversion, neuroticism, agreeableness, openness and conscientiousness) on the associations between social isolation, loneliness and dementia among middle and old age Black men.