Social Isolation, Loneliness and Dementia Among Middle and Old Age Black Men

中老年黑人的社会孤立、孤独和痴呆症

• 批准号: 10285198
• 负责人: ROLAND J. THORPE
• 金额: $ 8.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285198
• 关键词: Address; Administrative Supplement; Adult; Affect; African American; Age; Aging; Alzheimer' s disease related dementia; Area; Award; Beech; Behavioral; Biological; Biological Markers; Cause of Death; Cessation of life; Chronic Disease; Data; Data Set; Dementia; Development; Disease; Economics; Environment; Exposure to; Extroversion; Family; Foundations; Functional disorder; Gap Junctions; Gender; Genes; Genetic; Goals; Health; Health and Retirement Study; Impaired cognition; Independent Scientist Award; Knowledge; Lead; Life; Life Cycle Stages; Link; Loneliness; Longevity; Maintenance; Mentors; Modeling; Neighborhoods; Neurotic Disorders; Onset of illness; Outcome; Personality Traits; Physiological; Population; Positioning Attribute; Premature Mortality; Psychological Stress; Publishing; Race; Reproduction; Research; Resources; Risk; Role; Scientist; Social Behavior; Social Interaction; Social Network; Social isolation; Stress; Structure; System; Time; Underrepresented Minority; United States; Work; behavioral economics; biopsychosocial; black men; career; coping; early onset; economic determinant; experience; healthy aging; human old age (65+); in utero; male health; men; middle age; minority investigator; mortality; novel; parent grant; peer; premature; programs; protective factors; psychologic; psychosocial; response; social; social factors; social relationships; social stress; stressor; systemic inflammatory response; theories

ABSTRACT Alzheimer’s disease and related dementias (ADRD) is prevalent in approximately 6 million people and is the 6th leading cause of death among adults in the United States. The burden of ADRD is not equally distributed across populations as rates among Blacks are two to three times greater than their White peers. Black males are disproportionately represented among those with ADRD, however, they few studies have exclusively focused on this population. The maintenance of accessible and supportive social networks during middle and older ages are influenced by personality trait and has been shown to be a protective factor for cognitive decline and onset of ADRD. The Caciappo Evolutionary Theory of Loneliness posits that beneficial social interactions and reliable social relationships can contribute to the longevity of life, reproduction and genetic legacy. This theory leverages the work of Weiss that conceptualizes loneliness as perceived isolation that is a “gnawing, chronic disease without redeeming features”. This project seeks to examine how personality trait, social isolation and loneliness impact dementia onset among middle to older age Black males. The aims for the proposed supplement are to: 1) Investigate the independent association of social isolation and loneliness on dementia among middle and old age Black men; and 2) Examine the impact of the 5-factor model personality traits (e.g. extroversion, neuroticism, agreeableness, openness and conscientiousness) on the associations between social isolation, loneliness and dementia among middle and old age Black men.

摘要 阿尔茨海默病和相关痴呆症(ADRD)在大约600万人中流行 它是导致美国成年人死亡的第六大原因。背负着 ADRD在各人群中的分布并不均匀，因为黑人中的ADRD发病率为2到3 比他们的白人同龄人大几倍。黑人男性在中国的比例不成比例 然而，那些患有ADRD的人很少有研究专门针对这一人群。这个 在中老年期间维护可访问和支持性的社交网络是 受个性特征影响，已被证明是认知能力下降的保护性因素 和ADRD的发作。卡恰波的孤独进化论认为， 社会互动和可靠的社会关系有助于延长寿命， 生殖和遗传遗产。这一理论充分利用了韦斯的工作，他将 孤独是一种被感觉到的孤立，是一种没有救赎的折磨人的慢性病 特点“。该项目旨在研究人格特征、社会孤立和孤独 影响中老年黑人男性的痴呆症发病。建议的目标是 补充如下：1)调查社交孤立和孤独的独立关联 关于中老年黑人男性痴呆症的研究；2)检验5个因素的影响 模范人格特征(例如，外向、神经质、随和、开放和 关于社交孤立、孤独和痴呆症之间的联系 在中老年黑人男性中。