PA-18-591 Religiosity, Spirituality, Stress, Health and Mortality among Middle to Old Age Black Men (Supplement to Stress and Mortality Among Black Men)

PA-18-591 中老年黑人的宗教信仰、灵性、压力、健康和死亡率（黑人男性压力和死亡率的补充）

• 批准号: 9755819
• 负责人: ROLAND J. THORPE
• 金额: $ 6.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9755819
• 关键词: Address; Administrative Supplement; Affect; Age; Aging; Area; Attention; Award; Awareness; Behavioral; Biological; Biological Factors; Biological Markers; Cessation of life; DNA Methylation; Data; Data Set; Development; Discrimination; Disease; Doctor of Philosophy; Economics; Elderly; Environment; Epigenetic Process; Ethnic group; Exposure to; Family; Foundations; Gap Junctions; Gender; Genes; Genetic; Genetic Predisposition to Disease; Goals; Health; Health Benefit; Health and Retirement Study; Independent Scientist Award; Individual; Interleukin-6; Intervention; Knowledge; Lead; Length; Life; Life Cycle Stages; Life Expectancy; Link; Longevity; Mediating; Mentors; Modeling; Neighborhoods; Outcome; Pathway interactions; Pattern; Personal Satisfaction; Physiological; Population; Positioning Attribute; Premature Mortality; Psychological Stress; Race; Religion and Spirituality; Reporting; Research; Risk; Role; Social Behavior; Spirituality; Stress; Structure; Time; To specify; Underrepresented Minority; Woman; Women' s Group; Work; behavioral economics; behavioral response; biopsychosocial; career; coping; coping mechanism; cost; cost efficient; disability; economic determinant; experience; functional status; genomic biomarker; health disparity; healthy aging; improved; male health; men; middle age; minority investigator; mortality; novel; premature; programs; psychologic; psychosocial; racial and ethnic; racial discrimination; response; social; social stress; stressor; telomere

PROJECT SUMMARY Black men experience extremely high levels of social and psychological stress from unfavorable social and economic circumstances emerging from institutional discrimination and unfair treatment. Early exposure to stress and its rapid accumulation over the lifecourse can contribute to disproportionate risks for illness, disease and premature mortality among this population. The three-hit concept (hit 1: genetic predisposition; hit 2: early- life environment; hit 3: later-life environment) suggests that the poor health of Black men may be a function of interactions between cumulative stress, epigenetic mechanisms, and biological responses. Religiosity and spirituality have been found to impact health and the objective of this study is to examine how religiosity (practices associated with organized religion) and spirituality (individuals experiences with, awareness of, and connection to the transcendent) impact stress and its implications for improving the well-being and longevity of middle to old age Black men. This proposed study will use data from the Healthy Aging in Neighborhoods of Diversity Across the Life Span Study (HANDLS) and the Health and Retirement Study (HRS) to specify models guided by a biopsychosocial perspective. The specific aims are to: 1) Investigate the independent associations of religiosity and spirituality on psychological and behavioral responses to stress, functional status, and mortality; 2) Investigate the interdependent relationships of religiosity and spirituality on psychological and behavioral responses to stress, functional status, and mortality; and 3) Examine the impact of religiosity and spirituality on biological and genomic markers to elucidate potential basic mechanisms through which they mediate the relationship between stress and mortality. Results from the proposed project will advance our understanding of religion and spirituality on health in the group most vulnerable to premature death. In addition, the proposed research will be used to inform subsequent studies focusing on the health benefits of religiosity and spirituality among Black men that can lead to religious and spiritual interventions which are highly scalable not only to Black men but potentially all racial/ethnic groups and genders, and at low/no cost.

项目摘要 黑人经历了不利的社会和心理压力的极高水平 机构歧视和不公平待遇源于经济环境。早期接触 压力及其对生命的迅速积累可能导致疾病，疾病的风险不成比例 和该人群的过早死亡。三击概念（命中1：遗传易感性；命中2：早期 - 生活环境；命中3：后期的环境）表明，黑人健康状况不佳可能是 累积应激，表观遗传机制和生物学反应之间的相互作用。宗教和 已经发现灵性会影响健康，这项研究的目的是研究宗教信仰 （与有组织的宗教相关的实践）和灵性（个人经历，意识和 与超然的联系）影响压力及其对改善福祉和寿命的影响 中年至老年黑人。这项拟议的研究将使用来自健康衰老的数据 整个生命周期研究（Handls）和健康与退休研究（HRS）的多样性以指定模型 以生物心理社会的观点为指导。具体目的是：1）调查独立协会 对压力，功能状况和行为反应的宗教信仰和灵性 死亡; 2）研究宗教和灵性在心理和灵性上的相互依存关系 行为对压力，功能状况和死亡率的反应； 3）检查宗教信仰的影响和 生物学和基因组标记的灵性，以阐明它们的潜在基本机制 调解压力和死亡率之间的关系。拟议项目的结果将推动我们的 对最容易过早死亡的宗教和灵性的理解。此外， 拟议的研究将用于告知随后的研究，重点是宗教的健康益处 黑人之间的灵性，可以导致高度扩展的宗教和精神干预 不仅对黑人，而且可能是所有种族/族裔和性别，而且价格低/无成本。