PA-18-591 Religiosity, Spirituality, Stress, Health and Mortality among Middle to Old Age Black Men (Supplement to Stress and Mortality Among Black Men)

项目总结 黑人男性承受着极高的社会和心理压力，来自不利的社会和 体制歧视和不公平待遇造成的经济环境。早期接触 压力及其在生命过程中的快速积累可能会导致不成比例的疾病风险 以及这一人群中的过早死亡。三个热门概念(Hit 1：遗传易感性；Hit 2：早期- 生活环境；HIT 3：晚年生活环境)表明黑人男性的健康状况不佳可能是 累积应激、表观遗传机制和生物反应之间的相互作用。宗教信仰和 已经发现灵性对健康有影响，这项研究的目的是研究宗教信仰如何 (与有组织的宗教有关的实践)和灵性(个人对此的体验、认识和 与超乎寻常的)冲击应力的关系及其对改善健康和寿命的影响 中老年黑人男性。这项拟议的研究将使用来自健康老龄化社区的数据 生命周期多样性研究(HANDLS)和健康与退休研究(HRS)以指定模型 以生物心理社会观点为指导。具体目标是：1)调查独立协会 宗教信仰和灵性对压力的心理和行为反应，功能状态，以及 2)探讨宗教信仰与灵性在心理和心理上的相互依存关系。 对压力、功能状态和死亡率的行为反应；以及3)检查宗教信仰和 灵性对生物和基因组标记的影响，以阐明它们通过哪些潜在的基本机制 调节压力和死亡率之间的关系。拟议项目的结果将推动我们的 了解宗教和灵性对最容易过早死亡的人群的健康影响。此外, 这项拟议的研究将被用来为后续专注于宗教信仰对健康益处的研究提供信息。 以及黑人男性的灵性，可以导致高度可扩展的宗教和精神干预 不仅对黑人男性，而且可能对所有种族/民族群体和性别都是如此，而且成本很低/免费。

PROJECT SUMMARY Black men experience extremely high levels of social and psychological stress from unfavorable social and economic circumstances emerging from institutional discrimination and unfair treatment. Early exposure to stress and its rapid accumulation over the lifecourse can contribute to disproportionate risks for illness, disease and premature mortality among this population. The three-hit concept (hit 1: genetic predisposition; hit 2: early- life environment; hit 3: later-life environment) suggests that the poor health of Black men may be a function of interactions between cumulative stress, epigenetic mechanisms, and biological responses. Religiosity and spirituality have been found to impact health and the objective of this study is to examine how religiosity (practices associated with organized religion) and spirituality (individuals experiences with, awareness of, and connection to the transcendent) impact stress and its implications for improving the well-being and longevity of middle to old age Black men. This proposed study will use data from the Healthy Aging in Neighborhoods of Diversity Across the Life Span Study (HANDLS) and the Health and Retirement Study (HRS) to specify models guided by a biopsychosocial perspective. The specific aims are to: 1) Investigate the independent associations of religiosity and spirituality on psychological and behavioral responses to stress, functional status, and mortality; 2) Investigate the interdependent relationships of religiosity and spirituality on psychological and behavioral responses to stress, functional status, and mortality; and 3) Examine the impact of religiosity and spirituality on biological and genomic markers to elucidate potential basic mechanisms through which they mediate the relationship between stress and mortality. Results from the proposed project will advance our understanding of religion and spirituality on health in the group most vulnerable to premature death. In addition, the proposed research will be used to inform subsequent studies focusing on the health benefits of religiosity and spirituality among Black men that can lead to religious and spiritual interventions which are highly scalable not only to Black men but potentially all racial/ethnic groups and genders, and at low/no cost.